Acute reversible pulmonary ischemia. A cause of the acute chest syndrome in sickle cell disease.

Abstract:

:A 6-year-old girl with sickle cell disease was admitted to the hospital with the diagnosis of the acute chest syndrome. The laboratory findings and the radionuclear lung scan supported a diagnosis of pulmonary infarction rather than pneumonia. She improved with intravenous fluids, oxygen, penicillin, and theophylline. The most likely explanation for the rapid resolution of the clinical syndrome, the chest x-ray, and lung scan abnormalities is that masses of sickled cells caused transient pulmonary vascular occlusion leading to perfusion defects and ischemia, and that the sickled cell thrombi were dislodged before the infarction occurred. To our knowledge, this phenomenon has not been described as a cause of the acute chest syndrome in sickle cell disease in children.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Babiker MA,Obeid HA,Ashong EF

doi

10.1177/000992288502401209

subject

Has Abstract

pub_date

1985-12-01 00:00:00

pages

716-8

issue

12

eissn

0009-9228

issn

1938-2707

journal_volume

24

pub_type

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