Reversal of central nervous system involvement in hemolytic uremic syndrome by use of plasma exchanges.

Abstract:

:A 12-year-old girl presented with weakness, diplopia, and lethargy after a prodrome of gastroenteritis. Laboratory studies were compatible with a diagnosis of hemolytic uremic syndrome. She developed seizures that were controlled by diphenylhydantoin and valium. In spite of peritoneal dialysis and fresh frozen plasma infusions, she progressed to a left hemiplegia associated with a brain scan finding of decreased blood flow in the right middle cerebral artery perfusion area. A 5 liter whole blood exchange transfusion did not improve the neurological status or low platelet count. Daily plasma exchanges with fresh frozen plasma replacement resulted in normal platelet count within 48 hours and was followed by progressive improvement in neurological status. Platelet agglutinating factor decreased to control levels. A repeat brain scan was normal.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Sheth KJ,Leichter HE,Gill JC,Baumgardt A

doi

10.1177/000992288702601208

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

651-6

issue

12

eissn

0009-9228

issn

1938-2707

journal_volume

26

pub_type

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