Abstract：
:We examined the effect of lateral spatial resolution and reader specialty on the accuracy of detection of breast cancer. The motivation for this pilot study was the need to acquire and display very large data sets in whole-specimen 3D digital breast histopathology imaging. The ultimate goal is to determine the minimum resolution adequate for detection of malignancy. Twenty-three histologic slides were selected from breast pathology cases and digitized at 2 sampling distances (3.2 and 1.9 microm pixels). Images were viewed by 14 pathologists, of whom 5 had breast pathology as their primary specialty. The readers assessed the likelihood of malignancy on a 5-point Likert scale, and provided a provisional diagnosis. For the detection task, sensitivity, specificity, overall accuracy of detection, and area under the receiver-operator curve were calculated. An overall diagnostic score, and scores grouped by malignancy type, were also computed. Outcome measures were examined for significant resolution and specialty effects. Increasing the lateral resolution significantly improved accuracy in diagnosis (P=.004) but no effect was found for detection. Breast specialists achieved significantly higher scores for all outcome measures except specificity. Differences in performance between the 2 groups of readers tended to be greater for the diagnostic task compared to detection, especially at the higher resolution. However, specimen coverage may also be a significant factor. Factors related to the readers may have also affected performance in this study. Based on these results, a more comprehensive study should examine pixel sizes between 0.7 and 1.9 microm.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Clarke GM,Zubovits JT,Katic M,Peressotti C,Yaffe MJdoi
10.1016/j.humpath.2007.04.006subject
Has Abstractpub_date
2007-12-01 00:00:00pages
1764-71issue
12eissn
0046-8177issn
1532-8392pii
S0046-8177(07)00193-1journal_volume
38pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:A case of scrotal and penile extramammary Paget's disease (EMPD) and concurrent prostate adenocarcinoma in a 59-year-old patient is presented. Immunohistochemically, the tumor cells of both the EMPD and prostate stained positively for prostate-specific antigen. Six previously reported cases of EMPD associated with pro...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(94)90229-1
更新日期：1994-06-01 00:00:00
abstract：:It has been proposed that an epithelial injury may be one of the multiple primary events in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The aim of this study was to characterize the tight junction and adherens junction proteins in normal human lung, IPF, cryptogenic organizing pneumonia, and asbestosis. W...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.08.016
更新日期：2013-05-01 00:00:00
abstract：:We report novel renal histopathologic features in a patient with hemolytic uremic syndrome after allogeneic bone marrow transplantation who survived with plasma exchange therapy. This distribution of vascular lesions within the kidney differed from previously described cases, which were uniformly fatal, in that there ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90210-4
更新日期：1989-01-01 00:00:00
abstract：:Adamantinoma of long bones is a rare skeletal tumor of unknown origin with epithelial and fibrous elements. The ill-defined distinction between the two components in some cases earlier led to the assumption that these might be derived from the same (mesenchymal) stem cell. In this study, we investigated the distributi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90104-0
更新日期：1997-02-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is frequent in human immunodeficiency virus (HIV)-infected patients. It is known to have an aggressive course in significantly immunosuppressed patients, and cirrhosis C has become one of the main causes of mortality in HIV-HCV coinfected patients since the improvement of antiretrovir...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.05.009
更新日期：2004-09-01 00:00:00
abstract：:Overexpression of the Eph receptor tyrosine kinases in cancers is related to malignant transformation, metastasis, tumor differentiation, and prognosis. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. In the present study, expression of EphA7 in gastric cancer cell lines ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.01.030
更新日期：2007-11-01 00:00:00
abstract：:It is currently thought that most clear cell and endometrioid carcinomas arise from ovarian endometriosis. We recently suggested that, besides their origin in the ovary, reduction of CDC42 messenger RNA (a member of the RHO GTPase family) may contribute to explain why clear cell carcinomas are not uncommonly found lim...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.06.020
更新日期：2012-05-01 00:00:00
abstract：:We describe the pathology of 5 patients with germline PRKACA copy number gain and Cushing syndrome: 4 males and 1 female, aged 2 to 43 years, including a mother and son. Imaging showed normal or slightly enlarged adrenal glands in 4 patients and a unilateral mass in the fifth. Biochemically, the patients had corticotr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.09.005
更新日期：2015-01-01 00:00:00
abstract：:Sessile serrated adenomas and traditional serrated adenomas are pathogenetically related to inhibition of apoptosis. Survivin and hedgehog proteins, including sonic hedgehog, patched, and smoothened, inhibit apoptosis, with hedgehog proteins forming a signal transduction cascade implicated in digestive cancers. This s...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.12.004
更新日期：2007-05-01 00:00:00
abstract：:Intraductal papillary neoplasm of the liver (IPNL) is a precursor lesion of intrahepatic cholangiocarcinoma (ICC) arising in hepatolithiasis. In this study, 98 foci of IPNL identified in 39 surgically resected hepatolithiatic livers were investigated for expression of p16INK4a, cyclin D1, p21WAF1/CIP1, p53, mouse doub...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.08.014
更新日期：2004-12-01 00:00:00
abstract：:The drs gene was originally isolated from a rat primary embryo fibroblast cDNA library as a suppressor gene against v-src transformation. We have previously shown that expression of drs mRNA was markedly reduced in a variety of human cancer cell lines, including those of the colon, bladder, and ovary. Furthermore, int...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.125373
更新日期：2002-06-01 00:00:00
abstract：:The relationship between higher total lymph node resection number in colorectal cancer resection specimens and improved overall survival is well known. Recent studies describe an association between a high rate of microsatellite instability and a high total lymph node count in colorectal cancer. Higher lymph node retr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.002
更新日期：2012-08-01 00:00:00
abstract：:Although recurrence of viral hepatitis in liver transplants is common, data comparing recurrent hepatitis B (HB), hepatitis C (HC), and co-existing dual hepatitis B and C (HB&C) are sparse. Posttransplantation liver biopsies, along with molecular, serological, immunohistochemical, and clinical data from 27 patients wi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(00)80205-1
更新日期：2000-01-01 00:00:00
abstract：:The clinical and pathologic features of 15 new cases of the uncommon primary or granulomatous angiitis of the central nervous system (PACNS) are described. To date, only 108 such cases have been reported in the English literature. Clinically, most PACNS patients have been young or middle-aged (mean age, 45 years; rang...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(92)90238-x
更新日期：1992-02-01 00:00:00
abstract：:Loss or reduced expression of E-cadherin has been shown to be associated with poor survival in patients with bladder cancer. In numerous cases, loss of E-cadherin expression in bladder tumors has been accompanied by continued association of catenins with the membrane, suggestive of the expression of an alternative cad...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.21140
更新日期：2001-01-01 00:00:00
abstract：:The types of collagen present in a case of elastofibroma dorsi were determined using type specific, characterized collagen antibodies. The presence of type II collagen (normally present only in articular cartilage and in selected ocular structures) is discussed with regard to the pathogenesis of this lesion, and the u...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80107-4
更新日期：1981-02-01 00:00:00
abstract：:The absence of keratin staining in tumor cells from localized fibrous mesotheliomas in both paraffin-embedded and frozen sections with sensitive peroxidase-antiperoxidase and avidin-biotin techniques is described. In addition ot the absence of staining for whole-stratum corneum keratin proteins, sections were negative...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80077-5
更新日期：1984-05-01 00:00:00
abstract：:Dysplastic nevi are an important indicator of risk of cutaneous malignant melanoma. The study of and, particularly, international communication regarding this group of lesions have been hindered by a lack of precision in diagnosis. In an effort to broaden understanding, a panel of pathologists agreed upon a set of cri...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90078-4
更新日期：1991-04-01 00:00:00
abstract：:Fibroepithelial lesions (FEL) of the breast are notoriously difficult to classify on core needle biopsies. The goal of this study was to evaluate interobserver variability and accuracy of subclassifying difficult FELs into fibroadenoma (FA) and phyllodes tumors (PTs). We identified 50 breast core needle biopsies, init...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.09.001
更新日期：2016-01-01 00:00:00
abstract：:Spindle cell carcinoma (SpCC) is uncommon, with a predilection for the upper aerodigestive tract. Its histogenesis has not been resolved, although most authors support the sarcomatoid carcinoma concept. Ploidy analysis and proliferation indices have not been reported for laryngeal SpCCs. The authors examined the patho...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90175-1
更新日期：1997-06-01 00:00:00
abstract：:Cell growth in the normal prostate is regulated by a delicate balance between cell death and cell proliferation (ie, apoptotic v proliferative activity). Disruption of the molecular mechanisms that regulate these two processes may underline the abnormal growth of the gland leading to benign prostatic hyperplasia (BPH)...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90396-2
更新日期：1996-07-01 00:00:00
abstract：:In a series of approximately 80,000 lymph nodes, amyloid deposition was found in 18; 12 of those nodes were selected, on the basis of availability of specimens, for investigation by immunohistochemical typing to identify the protein of origin and by correlation with morphologic criteria and clinical information. Four ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80568-8
更新日期：1986-12-01 00:00:00
abstract：:Three ovarian thecomas were studied by ultrastructural and immunohistochemical techniques. In each tumor, a small number of tumor cells stained for estradiol. Vacuolated as well as plump non-vacuolated tumor cells were positive, but spindle-shaped cells were negative. Ultrastructural examination showed two principle c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80056-8
更新日期：1984-02-01 00:00:00
abstract：:Urethral caruncle is a benign polypoid mass of the urethral meatus in primarily postmenopausal women. Although a conclusive association with malignancy, urologic disorder, or systemic disease has not been established, often the lesion carries a challenging clinical differential diagnosis that includes malignancy. Conv...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.015
更新日期：2012-09-01 00:00:00
abstract：:Atypical mesothelial hyperplasia encountered in pleural fluid or in a pleural biopsy specimen raises the suspicion that one may be dealing with a diffuse malignant mesothelioma of the pleura. We studied eight cases with cytologic or histologic changes of mesothelial atypia thought to be suspicious for diffuse malignan...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90292-w
更新日期：1991-07-01 00:00:00
abstract：:Telomerase is a ribonucleoprotein enzyme associated with cellular immortality and has been detected in the vast majority of adult tumors. Wilms tumor is a histologically diverse embryonal malignancy of childhood, and the histological features of Wilms tumor and its precursor lesion, the nephrogenic rest, recapitulate ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90072-7
更新日期：1998-05-01 00:00:00
abstract：:In an attempt to identify patients best suited for limited surgery as well as those at risk for recurrence and increased mortality, the authors reviewed the clinical and pathologic features of 130 patients who had undergone partial mastectomy as primary treatment for breast cancer (adjuvant therapy was administered on...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80202-7
更新日期：1986-08-01 00:00:00
abstract：:Hepatocyte growth factor has been identified as a lymphangiogenic factor in experimental animal models. However, the correlation between hepatocyte growth factor or c-Met expression and lymphangiogenesis in human spontaneous tumors has been rarely reported, and the distribution pattern of c-Met on tumor-related lympha...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.03.012
更新日期：2011-10-01 00:00:00
abstract：:A rare example of melanoma arising in carcinoma ex pleomorphic adenoma is presented. The diagnosis, differential diagnosis, and putative histogenesis of the melanoma component are discussed. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.12.002
更新日期：2011-09-01 00:00:00
abstract：:Nonalcoholic steatohepatitis (NASH) refers to an alcoholic hepatitis-like histologic pattern found in nonalcoholic patients. A review of 543 liver biopsies diagnosed as alcoholic hepatitis yielded 49 cases of NASH. The patients were commonly middle-aged women who were obese and often diabetic. NASH was usually discove...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(89)90249-9
更新日期：1989-06-01 00:00:00
