Abstract：
:In order to investigate whether the autoantibody production in the course of African trypanosomiasis is the result of a generalized polyclonal activation or if it is a specific (antigen-dependent) phenomenon we looked for the presence of autoantibodies directed against autoantigens likely to be released (DNA) or unlikely to be released (thyroglobulin) into the circulation during human T. gambiense infection. Sera from 21 patients with African trypanosomiasis were screened for anti-native DNA or anti-denatured DNA antibodies by a Farr DNA binding radioimmunoassay. In addition, antibodies to native DNA were also assessed by indirect immunofluorescent assays using Crithidia luciliae or rat liver sections as substrates. Anti-thyroglobulin antibodies were studied by the passive hemagglutination technique. IgM levels and fluorescent anti-trypanosomal antibodies (FATA) were concomitantly evaluated. The denaturated DNA binding capacity was significantly higher in the sera from trypanosomiasis patients than in sera from healthy blood donors. These capacities were greater in patients with high IgM levels and high FATA titres. Anti-native DNA or anti-thyroglobulin antibodies were not detected. This preferential formation of anti-denatured DNA antibodies suggests a specific antigen-dependent) activation of autoreactive cells rather than a generalized polyclonal activation.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Daniel-Ribeiro C,Tirard S,Monjour L,Homberg JC,Gentilini Msubject
Has Abstractpub_date
1983-12-01 00:00:00pages
321-9issue
4eissn
0001-706Xissn
1873-6254journal_volume
40pub_type
杂志文章相关文献
ACTA TROPICA文献大全abstract：:Aedes aegypti and Aedes albopictus were reported to be significant as vectors of dengue fever. In Taiwan, the latter is distributed throughout the island while the former appears only south of the Tropic of Cancer; i.e., 23.5°N. In the past decade, there were five outbreaks with over 1000 cases of dengue fever in Taiw...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2013.10.013
更新日期：2014-02-01 00:00:00
abstract：:The role of phospholipids (PLs) in the signal transduction pathways that are activated by a mitogenic stimulus (foetal calf serum) in Trypanosoma cruzi epimastigotes (EPI) was investigated. Only phosphatidylinositol-bis-phosphate was significantly altered in this process. Other phosphoinositides, including major PLs s...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(99)00016-9
更新日期：1999-07-30 00:00:00
abstract：:Triatoma infestans is a mandatory haematophagous vector of Chagas disease in Brazil. Despite a large number of studies on the anti-haemostatic molecules present in its saliva, the role of its salivary components on parasite transmission is poorly understood. Here, we show that the bioactive lipid molecule, lysophospha...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.10.022
更新日期：2018-02-01 00:00:00
abstract：:A study of host preference in tsetse flies using a modified heteroduplex PCR-based method is described. Domestic and wild animal blood samples were collected to extract the corresponding reference DNAs. In Campo (south Cameroon), tsetse flies (mainly Glossina palpalis palpalis) were trapped and 41 bloodmeals were coll...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2004.03.006
更新日期：2004-07-01 00:00:00
abstract：:The formation of Babesia ovis sporozoites in salivary gland cells of the vector tick Rhipicephalus bursa was studied by electron microscopy. The kinetics of B. ovis were found lying intracellularly on the second day after infestation (a.i.) of the ticks. The parasites enlarged rapidly losing all features of the motile...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
abstract：:The study aimed to establish if there was any relationship between the blood group of the human host and schistosomiasis prevalence, intensity, incidence and related organ pathology. Urine and stool specimens were collected from the 735 school children attending a rural school in Zimbabwe to determine the Schistosoma ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(97)00671-2
更新日期：1997-05-30 00:00:00
abstract：:It has been observed that Triatoma infestans and Rhodnius prolixus females stridulate to reject copulatory attempts performed by males. In addition, triatomines stridulate when disturbed or handled. In the present study, the temporal structure and frequency spectra of vibrational signals produced by mechanically distu...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(01)00095-x
更新日期：2001-05-25 00:00:00
abstract：:Human cytochrome P450 2C8 is a highly polymorphic gene and shows variation according to ethnicity. The CYP2C8*2 is a slow drug metabolism allele and shows 10-24% frequency in Black populations. The objective of this study was to assess the prevalence of CYP2C8*2 allele in Botswana among the San (or Bushmen) and the Ba...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.01.028
更新日期：2016-05-01 00:00:00
abstract：:A quantitative framework is presented for the site-specific characterization of schistosomiasis transmission with the object of developing local control strategies. Central to the framework is a worm-burden model using ordinary differential equations of disease transmission in risk groups defined by residence and occu...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/s0001-706x(02)00018-9
更新日期：2002-05-01 00:00:00
abstract：:In this study we standardized a new technical approach in which the target mitochondrial DNA sequence (mtDNA) is amplified using a simple but sensitive PCR method as a tool to detect Plasmodium falciparum and Plasmodium vivax. Specific primers were designed to hybridize with cytochrome c oxidase genes of P. falciparum...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2009.02.003
更新日期：2009-07-01 00:00:00
abstract：:Brucellosis is endemic in the Republic of Kazakhstan, particularly in agro-pastoral areas. The purpose of this research is to study the epidemiological situation of brucellosis in livestock recorded in the Republic of Kazakhstan, and to identify the reasons why anti-brucellosis measures were not effective. The researc...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.12.028
更新日期：2019-03-01 00:00:00
abstract：:Data on soil-transmitted helminth (STH) infections and reinfection among Orang Asli (aborigine) schoolchildren and their nutritional and socioeconomic status were analyzed to investigate the pattern and the possible predictors of STH reinfection. In this longitudinal study, 120 (60 males and 60 females) Orang Asli pri...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.05.022
更新日期：2008-08-01 00:00:00
abstract：:Free Living Amoebae (FLA) of Acanthamoeba genus are widely distributed in the environment and can be found in the air, soil and water; and have also been isolated from air-conditioning units. In humans, they are causative agents of a sight-threating infection of the cornea, Acanthamoeba keratitis (AK) and a fatal infe...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2013.10.006
更新日期：2014-02-01 00:00:00
abstract：:While horizontal transmission (human-mosquito-human) of dengue viruses largely determines the epidemiology of the disease, vertical transmission (infected female mosquito- infected offspring) has been suggested as a mechanism that ensures maintenance of the virus during adverse conditions for horizontal transmission t...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.07.012
更新日期：2017-10-01 00:00:00
abstract：:The genus Anaplasma currently comprises 6 bacterial species mostly pathogenic to animals and/or human, including the zoonotic species Anaplasma phagocytophilum, the causative agent of tick-borne fever (TBF) of ruminants, and of granulocytic anaplasmosis of horses, dogs and human. Recently, novel potentially non-pathog...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.105286
更新日期：2020-02-01 00:00:00
abstract：:The aim of this study was to evaluate the shedding of Brucella abortus in the milk of cows vaccinated with a full dose of RB51 during lactation. Eighteen cows, nine previously vaccinated with S19 as calves and nine non-vaccinated, were immunized subcutaneously with 1.3×10(10)CFU of B. abortus RB51, 30-60days after par...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.04.012
更新日期：2016-08-01 00:00:00
abstract：:393 primary school children were screened for Schistosoma haematobium using four indirect techniques (a) history of haematuria, (b) visual appearance of urine and use of chemical reagent strips to detect presence of (c) blood and (d) protein in urine. Results showed that the use of chemical reagent strips for the dete...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：:Chagas disease is a major unsolved health issue in Latin America and an emerging threat worldwide. New drugs are urgently needed for chemotherapy as those available (benznidazole and nifurtimox) have variable efficacy and elevated toxicity. Efforts are actually oriented to improve tools and technologies (e.g. transgen...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.08.004
更新日期：2015-12-01 00:00:00
abstract：:African horse sickness- and bluetongue virus are orbiviruses transmitted by Culicoides biting midges (Diptera: Ceratopogonidae) to horses and to ruminants, respectively. Since the last epizootic outbreak of African horse sickness in 2007 in Senegal, extensive investigations have been undertaken to improve our knowledg...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.06.012
更新日期：2015-09-01 00:00:00
abstract：:Glutathione transferases (GSTs) are believed to be a major detoxification system in helminths. We describe the expression and functional analysis of EgGST, a cytosolic GST from Echinococcus granulosus, related to the Mu-class of mammalian enzymes. EgGST was produced as an enzymatically active dimeric protein (rEgGST),...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2009.12.003
更新日期：2010-04-01 00:00:00
abstract：:Rapid urbanization in resource poor countries often results in expansion of unplanned settlements with overcrowding and inadequate sanitation. These conditions potentially support transmission of schistosomiasis and soil transmitted helminths (STH), but knowledge on the occurrence, transmission and control of these in...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.01.012
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Few data are available for the prevalence of Strongyloides stercoralis in the Caribbean region. This frequently under diagnosed soil-transmitted helminth (STH) can result in long-term low intensity chronic infections that are asymptomatic or can cause varied intestinal disturbances. With autoinfections, infe...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.03.037
更新日期：2017-07-01 00:00:00
abstract：:The involvement of the central nervous system (CNS) by Schistosoma mansoni may or may not cause clinical manifestations. When symptomatic, neuroschistosomiasis mansoni (NSM) is one of the most severe presentations of this infection. The neurological manifestations are due to numerous granulomas grouped in confined are...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2008.04.007
更新日期：2008-11-01 00:00:00
abstract：:Human infections with the helminth species Strongyloides stercoralis encompass a wide clinical spectrum, ranging from asymptomatic carriage to life-threatening disease. The diagnosis of S. stercoralis is cumbersome and the sensitivity of conventional stool microscopy is low. New molecular tools have been developed to ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.07.019
更新日期：2015-10-01 00:00:00
abstract：:Since 1988, the Sultanate of Oman has experienced three outbreaks of paralytic poliomyelitis. The last outbreak occurred in December 1993 and involved two children aged 10 months and 4 1/2 years. The children had received five and four doses, respectively, of trivalent oral polio vaccine (OPV) and lived in the same vi...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(01)00166-8
更新日期：2001-10-22 00:00:00
abstract：:Wuchereria bancrofti, a nematode parasite causing human lymphatic filariasis is widely distributed in India. The phylogeography of this parasite was studied by constructing RAPD profiles of parasite populations collected from 71 microfilaria carriers residing in different geoclimatic regions of India. The analysis sho...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2006.06.004
更新日期：2006-07-01 00:00:00
abstract：:The two major African malaria vectors Anopheles gambiae sensu stricto and An. arabiensis are sibling species that occupy different climatic niches but are frequently found in the same larval habitats. Differences in survival and development of the aquatic larval stages of these species at different temperatures may he...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.09.025
更新日期：2009-02-01 00:00:00
abstract：:17-N-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) is an inhibitor of heat shock protein 90 (Hsp90), which has been studied in the treatment of cancer such as leukemia or solid tumors. Alternatively, 17-AAG may represent a promising therapeutic agent against leishmaniasis. However, the delivery of 17-AAG ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105595
更新日期：2020-11-01 00:00:00
abstract：:The influence of live Brugia malayi parasites and a Sephadex G-200 fraction of the adult parasite extract (BmAFII) on the progression of Leishmania donovani infection was studied. Inbred hamsters were first infected with B. malayi infective 3rd stage larvae (L3), adult worms or microfilariae (mf), and then with L. don...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.01.007
更新日期：2008-05-01 00:00:00
abstract：:The aims of this study were to describe the occurrence of dengue in space and time and to assess the relationships between dengue incidence and entomologic indicators. We selected the dengue autochthonous cases that occurred between September 2005 and August 2007 in São José do Rio Preto to calculate incidence rates b...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.11.017
更新日期：2015-02-01 00:00:00
