Abstract：
:Wuchereria bancrofti, a nematode parasite causing human lymphatic filariasis is widely distributed in India. The phylogeography of this parasite was studied by constructing RAPD profiles of parasite populations collected from 71 microfilaria carriers residing in different geoclimatic regions of India. The analysis showed that the phylogeography of W. bancrofti populations is complex, with a high genetic divergence and gene flow among populations. The total genetic diversity (H(T)) and genetic differentiation (G(ST)) estimated for all the parasite populations were 0.0926 and 0.5859, respectively. The gene flow (Nm) between different regions indicated that two strains of W. bancrofti were prevalent in the country, one in the eastern side and the other on the western side of the Western Ghats. A highly significant genetic differentiation (F(ST) [theta] = 0.7978) was estimated between these two strains (chi 2 = 308.2789; P < 0.001). The gene flow between these strains was very low (0.2338). These two strains appear to have drifted genetically because of their geographic isolation by this thickly forested mountain range. The strain in the eastern side was found to be monophyletic in origin and is undergoing genetic divergence as the major parasite population in the country, spanning from eastern peninsular region to the northern plains. The variable geoclimatic factors and the antifilarial chemotherapeutical pressure on the parasite, which is in place for the past half a century, might have contributed for the high genetic heterogeneity its strains/populations in the country. The route of entry of the parasite into Indian sub-continent possibly appeared to be from an ancient origin from the countries of the Southeast Asian archipelago, through the eastern coastal line of the southern peninsula.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Thangadurai R,Hoti SL,Kumar NP,Das PKdoi
10.1016/j.actatropica.2006.06.004subject
Has Abstractpub_date
2006-07-01 00:00:00pages
297-304issue
3eissn
0001-706Xissn
1873-6254pii
S0001-706X(06)00103-3journal_volume
98pub_type
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