CRP gene is involved in the regulation of human longevity: a follow-up study in Finnish nonagenarians.

abstract：:Nuclear envelopes of mammalian cells contain a nucleoside triphosphatase which is probably involved in mRNA transport through the nuclear membrane. The activity of the enzyme, studied in RNA-depleted nuclear ghosts, can be stimulated by poly(A) or by poly(A) (+)mRNA. Using nuclear ghost preparations from mature (8-10 ...

journal_title：Mechanisms of ageing and development

authors： Bernd A,Schröder HC,Zahn RK,Müller WE

更新日期：1982-12-01 00:00:00

abstract：:Possible alterations in the population of poly(A)(+)mRNA during ageing were investigated by translation in vitro of poly(A)(+)mRNA from the liver, kidney and brain of male ddY mice of different ages. [35S]Methionine-labeled translation products were analysed by two-dimensional polyacrylamide gel electrophoresis follow...

journal_title：Mechanisms of ageing and development

authors： Anzai K,Imazato C,Goto S

更新日期：1983-10-01 00:00:00

abstract：:Putrescine, spermidine, spermine and two unknowns designated as A and B were detected in first seedling leaves of barley (Hordeum vulgare L. var. Wolfe). The levels of these polyamines in first seedling leaves from 4-day-old barley plants grown in darkness or in light were comparable and did not change significantly a...

journal_title：Mechanisms of ageing and development

authors： Srivastava BI

更新日期：1987-09-14 00:00:00

abstract：:The intralobular distribution of three lysosomal enzymes, acid phosphatase, N-acetyl-beta-D-glucosaminidase, and beta-D-glucuronidase, was investigated in hepatocytes of 3-, 12-, 24-, and 36-month-old rats. The distribution pattern changed with age. In young rats, the activity was higher in the peripheral area than in...

journal_title：Mechanisms of ageing and development

authors： van Manen R,de Priester W,Knook DL

更新日期：1983-06-01 00:00:00

abstract：:In a longitudinal design in which each animal was examined repeatedly throughout its life, we used flow cytometry to determine the numbers or proportions of a variety of T lymphocyte subsets in the peripheral blood of mice aged 8-20 months. Half of the 128 mice were given a low calorie diet which is known to extend li...

journal_title：Mechanisms of ageing and development

authors： Miller RA

更新日期：1997-06-01 00:00:00

abstract：:Oxidative energy metabolism in mouse liver mitochondria was examined during weaning using different substrates. During the post-natal development, from suckling to weanling stage, the respiration rates showed a temporary decrease. These altered levels recovered in the adults. Respiration rates with the three substrate...

journal_title：Mechanisms of ageing and development

authors： Subramanian M,Katyare SS

更新日期：1990-05-30 00:00:00

abstract：:The quantification of plasmatic HLA class-I molecules (sHLA-I) was realized by a sandwich ELISA using a monomorphic mAb (W6/32). sHLA-I concentration is significantly increased in the elderly group (>50 years, 0.429+/-0.301 microg ml(-1)) as compared to the young group (<50 years, 0.126+/-0.085 microg ml(-1)). The var...

journal_title：Mechanisms of ageing and development

authors： Le Morvan C,Cogné M,Drouet M

更新日期：2001-03-01 00:00:00

abstract：:A comparison was made of the resting membrane potential (MP) as well as the MP responses to K+, ACTH and gamma-MSH of superfused adrenocortical, zona fasciculata cells from young (Y) and old (O) male rats. The resting MP of these cells did not vary with age. However, the MP responses to altered extracellular [K+] vari...

journal_title：Mechanisms of ageing and development

authors： Lymangrover JR,Valego NK,Shilling RD

更新日期：1988-06-01 00:00:00

abstract：:A method has been developed for the direct measurement of genetic variants in mammalian cells in culture which does not require cell division and is therefore suitable for ageing studies. Previous evidence suggests that these variants are mutations. The variant frequency was measured during the lifespan of populations...

journal_title：Mechanisms of ageing and development

authors： Fulder SJ

更新日期：1979-04-01 00:00:00

abstract：:The responses of the left and right ventricles (LV and RV) to physical conditioning in cold (25 degrees C) and thermoneutral temperatures (35 degrees C), with special reference to lactate dehydrogenase (LDH) and its isoenzyme profile, were studied in the 2-month (young)- and 12-month (middle-aged)-old rats. Moderate h...

journal_title：Mechanisms of ageing and development

authors： Prathima S,Devi SA

更新日期：1999-04-01 00:00:00

abstract：:The effects of age on estrogen stimulated nuclear RNA polymerase II activity were studied in uteri of ovariectomized mature (6-8 months) and senescent (24 months) rats. Basal levels of RNA polymerase II activity were the same in both age groups. Following 17 beta-estradiol (E2) administration, RNA polymerase II activi...

journal_title：Mechanisms of ageing and development

authors： Haji M,Roth GS

更新日期：1984-04-01 00:00:00

abstract：:An age-related decline in blood-brain barrier transport of thyroid hormones may contribute to the central nervous system changes with aging. To test this hypothesis, the brain uptake index (BUI) of levo (L) and dextro (D) triiodothyronine (T3) was determined in male Fischer 344 rats at 6 months of age (young) and 26 m...

journal_title：Mechanisms of ageing and development

authors： Mooradian AD

更新日期：1990-03-15 00:00:00

abstract：:Healthy elderly (80+/-5 years) with different nutritional status were compared to young healthy adults (25+/-5 years) to quantify the relative influences of aging and nutrition on immune response. Aged persons, without alteration of their nutritional status, had lower CD3+, CD8+, and CD45RA+ as well as higher CD2+CD3-...

journal_title：Mechanisms of ageing and development

authors： Mazari L,Lesourd BM

更新日期：1998-08-01 00:00:00

abstract：:The kinetics of accumulation and loss of zinc from the liver following subcutaneous administration of 10 mg of zinc per kg were examined in young adult (6 months old) and old (24 months old) male C57BL/6J mice. After zinc treatment, total liver zinc concentrations rose equally in both groups and returned to basal leve...

journal_title：Mechanisms of ageing and development

authors： Thomas DJ,Winchurch RA,Adler WH

更新日期：1989-03-01 00:00:00

abstract：:Because muscle satellite cells have been implicated in the process of muscle growth and mass regulation, as well as regeneration, alterations in the capacity of satellite cells to differentiate and accumulate muscle specific proteins during aging could play a role in the process of senile muscle atrophy. Skeletal musc...

journal_title：Mechanisms of ageing and development

authors： Allen RE,McAllister PK,Masak KC,Anderson GR

更新日期：1982-01-01 00:00:00

abstract：:In the rat, kininogens are produced from two distinctly regulated gene families, T- and K-kininogens. We have previously established that T-kininogen (T-KG, thiostatin) gene expression is increased in the liver of old rats, as compared to their younger counterparts. In this report, we have used Northern blot analysis ...

journal_title：Mechanisms of ageing and development

authors： Sierra F

更新日期：1995-10-13 00:00:00

abstract：:The oral health of older people is changing with reducing numbers of people relying on complete dentures for function, and retaining some natural teeth. Despite this there are substantial numbers of older people whose ability to chew foods is compromised by their oral health status, either because they have few or no ...

journal_title：Mechanisms of ageing and development

authors： Walls AW,Steele JG

更新日期：2004-12-01 00:00:00

abstract：:We examined physiological changes in CD5(+) B lymphocytes in mice associated with aging (from 1 or 5 to 50 weeks of age). The most predominant populations of lymphocytes among these mice were mainly CD5(-) B cells in the spleen and peritoneal cavity, and T cells in the thymus. However, in the spleen, CD5(+) B cells in...

journal_title：Mechanisms of ageing and development

authors： Watanabe K,Watanabe M,Maruoka H,Amino N,Iwatani Y

更新日期：2001-10-01 00:00:00

abstract：:In the present work, we investigated whether IGF-1 regulates the transcription of the genes encoding the L-type Ca2+ channel (DHPR) channel and RyR1 in young adult and senescent mice. To this end, a transgenic mouse model overexpressing IGF-1 exclusively in skeletal muscle (S1S2) was studied at different ages and the ...

journal_title：Mechanisms of ageing and development

authors： Zheng Z,Messi ML,Delbono O

更新日期：2001-04-15 00:00:00

abstract：:Age-dependent renal damage is influenced by genetic background and the Fisher344xBrown Norway (F344xBN) rat is resistant to glomerular injury. In vulnerable strains, a fall in renal nitric oxide synthase (NOS) contributes to age-dependent renal damage. Here, we investigated renal NOS in young (3 months) and old (30 mo...

journal_title：Mechanisms of ageing and development

authors： Moningka NC,Sasser JM,Croker B,Carter C,Baylis C

更新日期：2011-01-01 00:00:00

abstract：:In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping...

journal_title：Mechanisms of ageing and development

authors： Leposavic G,Pejcić-Karapetrović B,Kosec D

更新日期：2002-02-01 00:00:00

abstract：:As measured by X-ray microanalysis of frozen-dried cryosections, physiological concentrations of phosphorus, Na+, K+ and Mg2+ show a biphasic age dependence in some compartments of rat hepatocytes, especially in the regions of condensed chromatin associated with the actively transcribed genes. This could be consistent...

journal_title：Mechanisms of ageing and development

authors： von Zglinicki T,Bimmler M

更新日期：1987-04-01 00:00:00

abstract：:Antioxidants and telomere length are potential biomarkers for individuals' exposure and ability to cope with environmental stressors. However, intraspecific variations in antioxidant alterations due to natural, life cycle related stress, have been rarely estimated. We investigated those changes in wild-derived house m...

journal_title：Mechanisms of ageing and development

authors： Stauffer J,Panda B,Ilmonen P

更新日期：2018-01-01 00:00:00

abstract：:Classical evolutionary theory predicts the existence of genes with antagonistic effects on longevity and various components of early-life fitness. Quantitative genetic studies have provided convincing evidence that such genes exist. However, antagonistic pleiotropic effects have rarely been attributed to individual lo...

journal_title：Mechanisms of ageing and development

authors： Leroi AM,Bartke A,De Benedictis G,Franceschi C,Gartner A,Gonos ES,Fedei ME,Kivisild T,Lee S,Kartaf-Ozer N,Schumacher M,Sikora E,Slagboom E,Tatar M,Yashin AI,Vijg J,Zwaan B

更新日期：2005-03-01 00:00:00

abstract：:We investigated the Coenzyme Q (CoQ) content of different mitochondrial fractions [free mitochondria (FM), synaptic heavy (HM) and light mitochondria (LM)] from three brain areas (cortex, striatum, hippocampus) of rats at different ages. In rats from 2 to 26 months of age, we observed only small differences in total C...

journal_title：Mechanisms of ageing and development

authors： Battino M,Gorini A,Villa RF,Genova ML,Bovina C,Sassi S,Littarru GP,Lenaz G

更新日期：1995-03-17 00:00:00

abstract：:Rats of two age groups (6 weeks and 30 months) received (1) a single dose of 600 mg D-galactosamine (GalN)/kg body weight by intraperitoneal (i.p.) injection, (2) a single dose of 600 mg GalN/kg body weight i.p. combined with 20 mg prednisolone/kg body weight subcutaneously at the beginning of the experiment. The kine...

journal_title：Mechanisms of ageing and development

authors： Platt D,Förster K,Förster L

更新日期：1978-03-01 00:00:00

abstract：:Hematopoietic stem cell performance and identity, crucial for homeostasis of the blood-forming system, is governed by extrinsic factors found in the bone marrow microenvironment. Communication within hematopoietic stem cell niches occurs via soluble factors or cell-to-cell contacts between niche and blood-forming cell...

journal_title：Mechanisms of ageing and development

authors： Böhm L,Helbing DL,Oraha N,Morrison H

更新日期：2020-10-01 00:00:00

abstract：:With recent sequencing of the genome and development of high-density array technology, it is now possible to assess global gene expression in cells/tissues by a technique that is sensitive, quantitative, and rapid. Gene expression array technology is extremely useful in studying a complex, multigenetic process, such a...

journal_title：Mechanisms of ageing and development

authors： Han E,Hilsenbeck SG

更新日期：2001-07-31 00:00:00

abstract：:Protein oxidation, one of a number of brain biomarkers of oxidative stress, is increased in several age-related neurodegenerative disorders or animal models thereof, including Alzheimer's disease, Huntington's disease, prion disorders, such as Creutzfeld-Jakob disease, and alpha-synuclein disorders, such as Parkinson'...

journal_title：Mechanisms of ageing and development

authors： Butterfield DA,Kanski J

更新日期：2001-07-15 00:00:00

abstract：:Mortality trends in industrialized countries are characterized by declines in vascular disease (ischemic heart disease and stroke) and rises in cancers and degenerative diseases. These trends are typically analyzed by examining each disorder in isolation using the perspective of genetic and environmental influences. H...

journal_title：Mechanisms of ageing and development

authors： Riggs JE,Millecchia RJ

更新日期：1992-09-01 00:00:00