What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?

abstract：:The bone marrow content, proliferative potential and proliferative activity of precursor cells for stromal fibroblast colony forming cells (CFC-F) were investigated in young and old CBA mice. The relationship between CFC-F and the number of bone marrow nucleated cells and granulocytic-macrophagal precursors (GM-CFC) w...

journal_title：Mechanisms of ageing and development

authors： Sidorenko AV,Andrianova LF,Macsyuk TV,Butenko GM

更新日期：1990-05-30 00:00:00

abstract：:In this paper, we approach the problem of attempting to understand senescence by understanding the complexity and hierarchical structure of mammalian organisms. To do this, we make use of some concepts from abstract relational biology; in particular, graph theory. We subsequently utilize these concepts to develop the ...

journal_title：Mechanisms of ageing and development

authors： Witten M

更新日期：1984-10-31 00:00:00

abstract：:Cellular senescence is a fundamental trait of many eukaryotic organisms. Senescent cells participate both in the developmental program and in normal ageing and age-related diseases. Senescence of proliferation-prone cells is a state of permanent cell cycle arrest accompanied by metabolic activity manifested by high se...

journal_title：Mechanisms of ageing and development

authors： Bielak-Zmijewska A,Mosieniak G,Sikora E

更新日期：2018-03-01 00:00:00

abstract：:We have isolated a new type of Paramecium tetraurelia mutant, named rie-2, that has a long immaturity period until autogamy. We previously isolated such an autogamy mutant, designated rie-1. These two mutants had some additional common features such as dependence of the occurrence of autogamy on the temperature, invol...

journal_title：Mechanisms of ageing and development

authors： Komori R,Sato H,Harumoto T,Takagi Y

更新日期：2005-06-01 00:00:00

abstract：:This review addresses a novel facet of human T cell biology that constitutes a fundamental problem for long-term maintenance of immunological memory against viruses. The finite proliferative capacity of human T lymphocytes is sufficiently great to accommodate the waves of clonal expansion associated with primary and e...

journal_title：Mechanisms of ageing and development

authors： Effros RB

更新日期：2000-12-20 00:00:00

abstract：:Ageing is the most complex phenotype currently known, since it becomes manifest in all organs and tissues, affects an organism's entire physiology, impacts function at all levels and increases susceptibility to all major chronic diseases. Insight into the molecular and cellular targets of the ageing process would offe...

journal_title：Mechanisms of ageing and development

authors： Vijg J,Suh Y

更新日期：2003-01-01 00:00:00

abstract：:Ceramide mediates the effects of several agonists leading to differentiation, apoptosis or senescence. We previously showed that ceramide becomes elevated in senescent fibroblasts. In the present study, senescent cultures of Wi-38 fibroblasts and human umbilical-vein endothelial cells were compared to low-passage cult...

journal_title：Mechanisms of ageing and development

authors： Venable ME,Webb-Froehlich LM,Sloan EF,Thomley JE

更新日期：2006-05-01 00:00:00

abstract：:The potential gain in life expectancy which could result from the complete elimination of mortality from cancer in the U.S. would not exceed 3 years if one were to consider cancer independently of other causes of death. In this paper, we review evidence of trade-offs between cancer and aging as well as between cancer ...

journal_title：Mechanisms of ageing and development

authors： Yashin AI,Ukraintseva SV,Akushevich IV,Arbeev KG,Kulminski A,Akushevich L

更新日期：2009-01-01 00:00:00

abstract：:Age-related and ambient temperature-related changes in motor activity, body temperature, body weight (b.w.), and food consumption were studied in the long-lived Peromyscus leucopus mouse at environmental temperatures of 29 and 21 degrees C. Major changes in physiological performance were observed between the young (6 ...

journal_title：Mechanisms of ageing and development

authors： Duffy PH,Feuers RJ,Pipkin JL,Turturro A,Hart RW

更新日期：1997-04-01 00:00:00

abstract：:The tumor suppressors p16(INK4a) and p53 have been implicated as contributors to age-associated stem cell decline. Key functions of p53 are the induction of cell cycle arrest, senescence, or apoptosis in response to DNA damage. Here, we examine senescence, apoptosis, and DNA damage responses in a mouse accelerated agi...

journal_title：Mechanisms of ageing and development

authors： Hinkal GW,Gatza CE,Parikh N,Donehower LA

更新日期：2009-04-01 00:00:00

abstract：:The bone marrow of old adult mice ( approximately 2 years old) has reduced B lymphopoiesis; however, whether the B1 pathway in adult bone marrow is also compromised in senescence is not known. Herein, we show that phenotypic (IgM(-)Lin(-)CD93(+)[AA4.1(+)] CD19(+)B220(low/-)) B1 progenitors are retained in old bone mar...

journal_title：Mechanisms of ageing and development

authors： Alter-Wolf S,Blomberg BB,Riley RL

更新日期：2009-06-01 00:00:00

abstract：:The incidence of chronic diseases such as cardiovascular diseases is lower in Mediterranean Southern Europe than Northern Europe. This may be due to a lower level of oxidative stress and a higher antioxidant status in people living around the Mediterranean Sea. Oxidative stress may influence the rate of shortening of ...

journal_title：Mechanisms of ageing and development

authors： de Vos-Houben JM,Ottenheim NR,Kafatos A,Buijsse B,Hageman GJ,Kromhout D,Giltay EJ

更新日期：2012-06-01 00:00:00

abstract：:The present review focuses on the effect of aging on flow-mediated outward remodeling (FMR) via alterations in estrogen metabolism, oxidative stress and inflammation. In ischemic disorders, the ability of the vasculature to adapt or remodel determines the quality of the recovery. FMR, which has a key role in revascula...

journal_title：Mechanisms of ageing and development

authors： Chehaitly A,Vessieres E,Guihot AL,Henrion D

更新日期：2020-12-14 00:00:00

abstract：:The localization of the beta/A4 amyloid precursor protein (APP) was studied in the human lumbar paravertebral sympathetic ganglia of subjects of different ages, free of neurologic disease, using combined immunohistochemistry and image analysis techniques (optic microdensitometry). To ascertain which cells displayed AP...

journal_title：Mechanisms of ageing and development

authors： Calzada B,Cabal A,Naves FJ,del Valle ME,Represa JJ,Vega JA

更新日期：1994-10-20 00:00:00

abstract：:The presence of damaged and microbial DNA can pose a threat to the survival of organisms. Cells express various sensors that recognize specific aspects of such potentially dangerous DNA. Recognition of damaged or microbial DNA by sensors induces cellular processes that are important for DNA repair and inflammation. He...

journal_title：Mechanisms of ageing and development

authors： Gasser S,Zhang WYL,Tan NYJ,Tripathi S,Suter MA,Chew ZH,Khatoo M,Ngeow J,Cheung FSG

更新日期：2017-07-01 00:00:00

abstract：:The touch smears of brain cells and hepatocytes of young and senescent mice were stained with antibody to cytidine nucleoside by an indirect immunofluorescence technique and subsequently combined with fluorescence cresyl violet staining of DNA. Nuclear binding of the antibody which reacts only with denatured or single...

journal_title：Mechanisms of ageing and development

authors： Nakanishi K,Shima A,Fukuda M,Fujita S

更新日期：1979-05-01 00:00:00

abstract：:In this review we discuss the yeast as a paradigm for the study of aging. The budding yeast Saccharomyces cerevisiae, which can proliferate in both haploid and diploid states, has been used extensively in aging research. The budding yeast divides asymmetrically to form a 'mother' cell and a bud. Two major approaches, ...

journal_title：Mechanisms of ageing and development

authors： Gershon H,Gershon D

更新日期：2000-12-01 00:00:00

abstract：:It has been shown in several studies that 2-mercaptoethanol (2-ME) improves the life span and aspects of life performance of laboratory animals. To obtain further details on the beneficial effects of 2-ME, a long-term study has been performed on male CBA/Ca inbred mice treated with this antioxidant. Four month-old mic...

journal_title：Mechanisms of ageing and development

authors： Pénzes L,Noble RC,Beregi E,Imre S,Izsák J,Regius O

更新日期：1988-10-01 00:00:00

abstract：:Epigallocatechin gallate(EGCG) is a monomer separated from tea catechins, as an well-known antioxidant, which helps fight wrinkles and rejuvenate skin cells. In this study, we investigated the anti-aging effect of EGCG, and to clarify underlying mechanism of skin aging in a d-galactose-induced aging mouse model. Forty...

journal_title：Mechanisms of ageing and development

authors： Chen J,Li Y,Zhu Q,Li T,Lu H,Wei N,Huang Y,Shi R,Ma X,Wang X,Sheng J

更新日期：2017-06-01 00:00:00

abstract：:It has been shown that enhanced levels of p53 activity contribute to reduced cancer susceptibility in mice, however longevity is compromised due to the onset of an early-ageing phenotype. The effects of enhanced levels of p53 in these in mice could therefore have implications for human premature ageing disorders. We e...

journal_title：Mechanisms of ageing and development

authors： O'Neill M,Núñez F,Melton DW

更新日期：2003-05-01 00:00:00

abstract：:A morphometric investigation has been carried out on the synaptic junctions in the cerebellar glomeruli of young-adult rats chronically deprived of vitamin E for 10 months and control animals of the same age. The following parameters were evaluated: the average length of the synapses (L), the numerical (NV) as well as...

journal_title：Mechanisms of ageing and development

authors： Bertoni-Freddari C,Giuli C,Pieri C

更新日期：1984-02-01 00:00:00

abstract：:Age-related changes in the activities of superoxide dismutase, catalase, and glutathione peroxidase were determined in brain, heart, hepatocytes, intestinal mucosa, and kidney from male Fischer F344 rats. Superoxide dismutase activity decreased significantly with age in all five tissues studied. The activity of catala...

journal_title：Mechanisms of ageing and development

authors： Rao G,Xia E,Richardson A

更新日期：1990-03-31 00:00:00

abstract：:Recent studies show that cellular and mitochondrial iron increases with age. Iron overload, especially in mitochondria, increases the availability of redox-active iron, which may be a causal factor in the extensive age-related biomolecular oxidative damage observed in aged organisms. Such damage is thought to play a m...

journal_title：Mechanisms of ageing and development

authors： Xu J,Marzetti E,Seo AY,Kim JS,Prolla TA,Leeuwenburgh C

更新日期：2010-07-01 00:00:00

abstract：:The activity of low Km cAMP-phosphodiesterase (PDE) was determined in extracts of prostate and heart of adult (10-12 months old) and aged (32-35 months old) Sprague-Dawley rats; the enzyme's response to endogenous inhibitors extracted from the two organs was analyzed by kinetic studies. Different mechanisms of inhibit...

journal_title：Mechanisms of ageing and development

authors： Moses MA,Szabo EI,Terner C

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper de...

journal_title：Mechanisms of ageing and development

authors： Berendsen A,Santoro A,Pini E,Cevenini E,Ostan R,Pietruszka B,Rolf K,Cano N,Caille A,Lyon-Belgy N,Fairweather-Tait S,Feskens E,Franceschi C,de Groot CP

更新日期：2013-11-01 00:00:00

abstract：:Normal diploid Syrian hamster dermal mesenchymal cell strains, regardless of the age of the tissue of origin, exhibit in vitro cellular senescence. The frequency of spontaneous escape from senescence and conversion to a permanent cell line is less than 5% among replicate flasks. The overall pattern of senescence of ce...

journal_title：Mechanisms of ageing and development

authors： Bruce SA,Deamond SF,Ts'o PO

更新日期：1986-04-01 00:00:00

abstract：:Understanding mechanisms underlying longevity, and endeavor towards the specific goals of alleviating frailty in old age, require a comprehensive approach that considers the various theoretical and experimental approaches, as well as compiling the data on humans. This logistic has underlined the program of the confere...

journal_title：Mechanisms of ageing and development

authors： Globerson A,Barzilai N

更新日期：2005-02-01 00:00:00

abstract：:Quantitative measurements of glycogen in aging bruchids showed there was a considerable decrease (> 50%) with age except on the fifth day when an increase was observed, followed by a decrease on the sixth day. The variations in glycogen content with age suggests that glycogen serves as one of the energy sources respon...

journal_title：Mechanisms of ageing and development

authors： Sharma SP,Sharma G

更新日期：1980-01-01 00:00:00

abstract：:The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to inc...

journal_title：Mechanisms of ageing and development

authors： Saul N,Pietsch K,Menzel R,Steinberg CE

更新日期：2008-10-01 00:00:00

abstract：:To test the validity of estimating age-related changes in rat liver nuclear RNA synthesis by following the incorporation of radioactive nucleotides into an acid-insoluble product, age-related changes in endogenous nucleotide concentration were investigated. Both the total nucleotide and the nucleoside monophosphate (N...

journal_title：Mechanisms of ageing and development

authors： Bolla RI,Miller JK

更新日期：1980-02-01 00:00:00