Abstract:
:Several investigators have demonstrated that under conditions where little or no gas exchange occurs across the alveolar capillary membrane the PCO(2) is higher in the alveolus than in the mixed venous blood, whereas there are no PO(2) differences. Gurtner et al. have explained the DeltaPCO(2) by a model in which H(+) dissociation of proteins due to an electrical field caused by a negatively charged capillary wall (Wien effect) sets up an intracapillary PCO(2) difference between wall and bulk phase which is maintained by blood flow. The model is not specific for CO(2) and predicts that weak acids should be concentrated in a manner similar to CO(2) whereas weak bases should be relatively excluded from the alveolar space. Measurements of the steady-state distribution of the uncharged forms of the weak acids 5,5-dimethyloxyazoladinedione (DMO) and barbital and of the weak base tris(hydroxymethyl)aminomethane (THAM) between mixed venous blood and a fluid-filled lobe of lung were made in living dogs. The results agree fairly well with the predicted values.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Gurtner GHdoi
10.1016/S0006-3495(72)86106-Xsubject
Has Abstractpub_date
1972-06-01 00:00:00pages
597-608issue
6eissn
0006-3495issn
1542-0086pii
S0006-3495(72)86106-Xjournal_volume
12pub_type
杂志文章abstract::Fluorescence lifetimes of dimeric rabbit muscle creatine kinase specifically dansylated at both active sites and the homologous monomeric lobster muscle arginine kinase singly dansylated were determined using phase-modulation methods with global analysis of overdetermined data sets. For both proteins, the data is adeq...
journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(91)82274-3
更新日期:1991-03-01 00:00:00
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journal_title:Biophysical journal
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更新日期:2018-04-24 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:2006-07-15 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(98)77517-4
更新日期:1998-07-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:2007-12-15 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(97)78791-5
更新日期:1997-03-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.106.083519
更新日期:2006-09-15 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.106.099838
更新日期:2007-03-15 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.105.070532
更新日期:2006-07-15 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/s0006-3495(75)85799-7
更新日期:1975-02-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(91)82316-5
更新日期:1991-05-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(84)84218-6
更新日期:1984-04-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(95)80084-6
更新日期:1995-11-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(92)81837-4
更新日期:1992-02-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2012.10.015
更新日期:2012-11-21 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2008.09.055
更新日期:2009-02-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(93)81379-1
更新日期:1993-02-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2010.07.060
更新日期:2010-10-06 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:2003-05-01 00:00:00
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journal_title:Biophysical journal
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更新日期:2008-04-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2016.01.023
更新日期:2016-02-23 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(99)77195-X
更新日期:1999-01-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:2015-10-20 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.104.041780
更新日期:2004-09-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:2009-08-05 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2011.10.058
更新日期:2012-01-18 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2014.05.024
更新日期:2014-07-01 00:00:00