Hypochlorhydria and hypergastrinaemia in rheumatoid arthritis.

abstract：:The effect of intranasal salmon calcitonin on pain, erosion progression, and bone loss in 40 women with rheumatoid arthritis was investigated. The study design was double blind, placebo controlled for the first four months and open for the next 36 months, allowing for cross over to active drug treatment or to the cont...

journal_title：Annals of the rheumatic diseases

authors： Sileghem A,Geusens P,Dequeker J

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:The British Society for Rheumatology Biologics Register (BSRBR) has collected data on adverse events including pregnancies in patients with rheumatoid arthritis treated with anti-tumour necrosis factor (anti-TNF) therapy. The purpose of this report is to summarise the pregnancy outcomes in women treated with ...

journal_title：Annals of the rheumatic diseases

authors： Verstappen SM,King Y,Watson KD,Symmons DP,Hyrich KL,BSRBR Control Centre Consortium, BSR Biologics Register.

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To measure gelatinase activities in paired synovial fluid (SF) and serum of patients with juvenile idiopathic arthritis (JIA), and to assess how these activities relate to clinical and laboratory measures of disease activity. METHODS:A quantitative protein substrate zymography method was adapted and validate...

journal_title：Annals of the rheumatic diseases

authors： Peake NJ,Foster HE,Khawaja K,Cawston TE,Rowan AD

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:To investigate whether the risk allele for systemic lupus erythematosus (SLE) in the signal transducer and activator of transcription factor 4 (STAT4) gene, defined by the single nucleotide polymorphism (SNP) rs10181656(G), is associated with vascular events and/or presence of prothrombotic anti-phospholipid ...

journal_title：Annals of the rheumatic diseases

authors： Svenungsson E,Gustafsson J,Leonard D,Sandling J,Gunnarsson I,Nordmark G,Jönsen A,Bengtsson AA,Sturfelt G,Rantapää-Dahlqvist S,Elvin K,Sundin U,Garnier S,Simard JF,Sigurdsson S,Padyukov L,Syvänen AC,Rönnblom L

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Progranulin (PGRN) was previously isolated as an osteoarthritis (OA)-associated growth factor. Additionally, PGRN was found to play a therapeutic role in inflammatory arthritis mice models through antagonising tumour necrosis factor α (TNF-α). This study was aimed at investigating the role of PGRN in degradat...

journal_title：Annals of the rheumatic diseases

authors： Zhao YP,Liu B,Tian QY,Wei JL,Richbourgh B,Liu CJ

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:We aimed to evaluate the dynamics of treatment response with different composite measures in the TIght COntrol of inflammation in early Psoriatic Arthritis (TICOPA) trial. METHODS:Participants with early disease-modifying antirheumatic drug-naïve psoriatic arthritis (PsA) were randomised 1:1 to either tight...

journal_title：Annals of the rheumatic diseases

authors： Coates LC,Mahmood F,Emery P,Conaghan PG,Helliwell PS

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:To study the ability of low-cost low-field dedicated extremity magnetic resonance imaging (E-MRI) to assess and predict erosive joint damage in the wrist and metacarpophalangeal (MCP) joints of patients with early rheumatoid arthritis. METHODS:24 previously untreated patients with rheumatoid arthritis with j...

journal_title：Annals of the rheumatic diseases

authors： Lindegaard HM,Vallø J,Hørslev-Petersen K,Junker P,Østergaard M

更新日期：2006-09-01 00:00:00

abstract：:Juvenile idiopathic arthritis (JIA) is not a disease, but an exclusion diagnosis that encompasses all forms of arthritis that begin before the age of 16 years, persist for more than 6 weeks, and are of unknown origin. This heterogeneous group of chronic arthritides has been classified on clinical and laboratory ground...

journal_title：Annals of the rheumatic diseases

authors： Martini A

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To assess and characterise the risk of bladder cancer, and its relation to cyclophosphamide, in patients with Wegener's granulomatosis. METHODS:In the population based, nationwide Swedish Inpatient Register a cohort of 1065 patients with Wegener's granulomatosis, 1969-95, was identified. Through linkage with...

journal_title：Annals of the rheumatic diseases

authors： Knight A,Askling J,Granath F,Sparen P,Ekbom A

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:A recent study from our laboratory showed that induction of the multidrug resistance related drug efflux pump ABCG2 contributed to acquired resistance of human T cells to the disease modifying antirheumatic drug (DMARD) sulfasalazine (SSZ). OBJECTIVES:To investigate the duration of SSZ resistance and ABCG2 ...

journal_title：Annals of the rheumatic diseases

authors： van der Heijden J,de Jong MC,Dijkmans BA,Lems WF,Oerlemans R,Kathmann I,Scheffer GL,Scheper RJ,Assaraf YG,Jansen G

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVES:To develop a questionnaire assessing the expectations of patients regarding management of osteoarthritis (OA of the knee. METHODS:A detailed document reporting on a qualitative analysis of interviews of patients with knee OA was sent to experts and a Delphi procedure was adopted for item generation. Eighty ...

journal_title：Annals of the rheumatic diseases

authors： Benhamou M,Boutron I,Dalichampt M,Baron G,Alami S,Rannou F,Ravaud P,Poiraudeau S

更新日期：2013-04-01 00:00:00

abstract：AIMS:The aim of this work was to assess the feasibility of using dynamic contrast enhanced (DCE) MRI of bone marrow oedema, to compare it with conventional marrow oedema scoring systems, and to determine the effects of anti-tumour necrosis factor (TNF)alpha therapy. METHODS:The wrist and metacarpophalangeal (MCP) join...

journal_title：Annals of the rheumatic diseases

authors： Hodgson R,Grainger A,O'Connor P,Barnes T,Connolly S,Moots R

更新日期：2008-02-01 00:00:00

abstract：:Gout and classical rheumatoid arthritis rarely coexist. We report a patient with strong evidence for both these diseases. Possible reasons for the negative correlation between these diseases are summarised. One hypothesis suggests inhibition of surface activity of monosodium urate crystals (MSU) by binding of rheumato...

journal_title：Annals of the rheumatic diseases

authors： Gordon TP,Ahern MJ,Reid C,Roberts-Thomson PJ

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVES:Statins offer significant cardiovascular benefits. Their use, however, influences immune regulation, which may potentially facilitate autoimmunity, eventually resulting in autoimmune diseases such as rheumatoid arthritis (RA).The authors studied whether statin use was associated with an increased risk of dev...

journal_title：Annals of the rheumatic diseases

authors： de Jong HJ,Klungel OH,van Dijk L,Vandebriel RJ,Leufkens HG,van der Laan JW,Cohen Tervaert JW,van Loveren H

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:Nicotinamide phosphoribosyltransferase (NAMPT)/pre-B-cell colony-enhancing factor/visfatin exerts multiple functions and has been implicated in the pathogenesis of rheumatoid arthritis. To gain insight into its role in arthritis and given that NAMPT is identified as a novel mediator of innate immunity, we ad...

journal_title：Annals of the rheumatic diseases

authors： Présumey J,Courties G,Louis-Plence P,Escriou V,Scherman D,Pers YM,Yssel H,Pène J,Kyburz D,Gay S,Jorgensen C,Apparailly F

更新日期：2013-10-01 00:00:00

abstract：:The possible contribution of immunological mechanisms in the development of Libman-Sacks endocarditis was studied in 2 patients with systemic lupus erythematosus who underwent aortic valve replacement. Sections of verrucous lesions, stained with haematoxylin and eosin, showed three apparently distinct zones: an outer ...

journal_title：Annals of the rheumatic diseases

authors： Shapiro RF,Gamble CN,Wiesner KB,Castles JJ,Wolf AW,Hurley EJ,Salel AF

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVE:To evaluate salivary hyaluronic acid (HA) concentration in patients with primary Sjögren's syndrome (SS). METHODS:Salivary and serum HA concentrations were evaluated using a radiometric assay. Thirty nine patients with SS served as the study group and their results were compared with 19 patients having clini...

journal_title：Annals of the rheumatic diseases

authors： Tishler M,Yaron I,Shirazi I,Yaron M

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the value of power Doppler ultrasound (PDUS) in combination with routine management in a cohort of patients with very early inflammatory arthritis (IA). METHODS:50 patients with < or =12 weeks of inflammatory symptoms with or without signs had clinical, laboratory and ima...

journal_title：Annals of the rheumatic diseases

authors： Freeston JE,Wakefield RJ,Conaghan PG,Hensor EM,Stewart SP,Emery P

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVES:To investigate the efficacy and safety of peficitinib, an oral Janus kinase inhibitor, in patients with rheumatoid arthritis (RA). METHODS:In this double-blind phase III study, patients with RA and an inadequate response to prior disease-modifying anti-rheumatic drugs (DMARDs) were randomised to peficitinib...

journal_title：Annals of the rheumatic diseases

authors： Tanaka Y,Takeuchi T,Tanaka S,Kawakami A,Iwasaki M,Song YW,Chen YH,Wei JC,Lee SH,Rokuda M,Izutsu H,Ushijima S,Kaneko Y,Akazawa R,Shiomi T,Yamada E

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:Wnt16 is implicated in bone fracture and bone mass accrual both in animals and humans. However, its functional roles and molecular mechanism in chondrocyte differentiation and osteoarthritis (OA) pathophysiology remain largely undefined. In this study, we analysed its mechanistic association and functional r...

journal_title：Annals of the rheumatic diseases

authors： Tong W,Zeng Y,Chow DHK,Yeung W,Xu J,Deng Y,Chen S,Zhao H,Zhang X,Ho KK,Qin L,Mak KK

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Knee osteoarthritis commonly requires joint replacement, substantially reduces quality of life and increases healthcare utilisation and costs. This study aimed to identify whether quantitative measures of articular cartilage structure predict knee replacement, and to establish their utility as outcomes in cli...

journal_title：Annals of the rheumatic diseases

authors： Eckstein F,Kwoh CK,Boudreau RM,Wang Z,Hannon MJ,Cotofana S,Hudelmaier MI,Wirth W,Guermazi A,Nevitt MC,John MR,Hunter DJ,OAI investigators.

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:To explore the efficacy of a tumour necrosis factor alpha (TNFalpha) inhibitor (etanercept, Enbrel) in patients with severe sciatica. METHODS:A pilot study of etanercept was conducted in patients admitted to hospital for acute severe sciatica. Ten consecutive patients received three subcutaneous injections ...

journal_title：Annals of the rheumatic diseases

authors： Genevay S,Stingelin S,Gabay C

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To define the role of ultrasound (US) for the assessment of patients with rheumatoid arthritis (RA) in clinical remission, including joint and tendon evaluation. METHODS:A multicentre longitudinal study has been promoted by the US Study Group of the Italian Society for Rheumatology. 25 Italian centres partic...

journal_title：Annals of the rheumatic diseases

authors： Filippou G,Sakellariou G,Scirè CA,Carrara G,Rumi F,Bellis E,Adinolfi A,Batticciotto A,Bortoluzzi A,Cagnotto G,Caprioli M,Canzoni M,Cavatorta FP,De Lucia O,Di Sabatino V,Draghessi A,Farina I,Focherini MC,Gabba A,Guti

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Anti-tumour necrosis factor (TNF) therapy may be associated with opportunistic infections (OIs). OBJECTIVE:To describe the spectrum of non-tuberculosis OIs associated with anti-TNF therapy and identify their risk factors. METHODS:A 3-year national French registry (RATIO) collected all cases of OI in patien...

journal_title：Annals of the rheumatic diseases

authors： Salmon-Ceron D,Tubach F,Lortholary O,Chosidow O,Bretagne S,Nicolas N,Cuillerier E,Fautrel B,Michelet C,Morel J,Puéchal X,Wendling D,Lemann M,Ravaud P,Mariette X,RATIO group.

更新日期：2011-04-01 00:00:00

abstract：:Expression of major histocompatibility complex (MHC) class II and other lymphocyte activation markers on peripheral blood and synovial fluid T lymphocytes from patients with rheumatoid arthritis (RA), psoriatic arthritis, and Reiter's syndrome were measured and the mean fluorescence intensities of these antigens were ...

journal_title：Annals of the rheumatic diseases

authors： Smith MD,Roberts-Thomson PJ

更新日期：1990-02-01 00:00:00

abstract：:The early changes (five weeks) in the structure of newly synthesised and endogenous articular cartilage sulphated proteoglycans were studied in lapine IgG induced experimental immune synovitis. Rabbits with immune synovitis (IS-IgG) were compared with animals with a developed hypersensitivity to IgG (I-IgG) and with n...

journal_title：Annals of the rheumatic diseases

authors： Malemud CJ,Yoo JU,Goldberg VM,Kresina TF

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVES:The aim of this pilot study was to compare clinical examination (CE) and ultrasound (US) with high field MRI (as the reference standard) for the detection of rearfoot and midtarsal joint synovitis and secondly tenosynovitis of the ankle tendons in patients with established rheumatoid arthritis (RA). METHODS...

journal_title：Annals of the rheumatic diseases

authors： Wakefield RJ,Freeston JE,O'Connor P,Reay N,Budgen A,Hensor EM,Helliwell PS,Emery P,Woodburn J

更新日期：2008-12-01 00:00:00

abstract：:The effect of immune complexes (IC) isolated from systemic lupus erythematosus (SLE) sera with polyethylene glycol and gel filtration on the chemotaxis and Fc receptor function of healthy monocytes was examined. Even at a low protein concentration (1 microgram/ml = 1 mg/l) ICs inhibit monocyte chemotaxis. ICs from pat...

journal_title：Annals of the rheumatic diseases

authors： Lukács K,Kávai M,Bányai A,Sonkoly I,Végh E,Szabó G,Szegedi G

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of anti-tumour necrosis factor (TNF) treatments (given for rheumatological manifestations) in reducing uveitis flares in patients with spondylarthropathy in daily practice. METHODS:A retrospective observational study of all patients with spondylarthropathy with at least one uveitis f...

journal_title：Annals of the rheumatic diseases

authors： Guignard S,Gossec L,Salliot C,Ruyssen-Witrand A,Luc M,Duclos M,Dougados M

更新日期：2006-12-01 00:00:00

abstract：:The regression of small rheumatoid nodules was noted in four patients after starting sulphasalazine therapy. This coincided with an improvement in synovitis and also falls in erythrocyte sedimentation rate (ESR) and C reactive protein (CRP). The relation between the nodule regression and the sulphasalazine therapy is ...

journal_title：Annals of the rheumatic diseases

authors： Englert HJ,Hughes GR,Walport MJ

更新日期：1987-03-01 00:00:00