Medicinal plants and the treatment of diabetes in Senegal: survey with patients.

abstract：:Abuse of alcohol triggers neurodegeneration in human brain. Minocycline has characteristics conferring neuroprotection. Current study evaluates the role of the CREB-BDNF signaling pathway in mediating minocycline's neuroprotective effects against alcohol-induced neurodegeneration. Seventy adult male rats were randomly...

journal_title：Fundamental & clinical pharmacology

authors： Motaghinejad M,Mashayekh R,Motevalian M,Safari S

更新日期：2020-06-24 00:00:00

abstract：:We reported that coronary spasm was induced in the transgenic mice with the increased phospholipase C (PLC)-δ1 activity. We investigated the effect of enhanced PLC-δ1 on Ca2+ influx and its underlying mechanisms. We used human embryonic kidney (HEK)-293 and coronary arteries smooth muscle cells (CASMC). Intracellular ...

journal_title：Fundamental & clinical pharmacology

authors： Murakami K,Osanai T,Tanaka M,Nishizaki K,Kinjo T,Tanno T,Ishida Y,Suzuki A,Endo T,Tomita H,Okumura K

更新日期：2017-08-01 00:00:00

abstract：:An antagonism between cholecystokinin (CCK) peptides and benzodiazepines (BZD) has been described in various paradigms. We sought to determine whether CCK and BZD are also antagonistic in their effects on brain neurotransmitter levels in the rat. No effect on the noradrenergic system was induced in any brain area by C...

journal_title：Fundamental & clinical pharmacology

authors： Rybarczyk MC,Orosco M,Rouch C,Jacquot C,Cohen Y

更新日期：1990-01-01 00:00:00

abstract：:We have previously shown that kaolinite slowed down gastric emptying and intestinal transit and induced changes in enteric mechanical activities. As gastric emptying and intestinal transit have been shown to be regulated by nitric oxide (NO), the effect of an imposed ingestion of kaolinite on enteric nitrergic innerva...

journal_title：Fundamental & clinical pharmacology

authors： Voinot F,Fischer C,Schmidt C,Ehret-Sabatier L,Angel F

更新日期：2014-08-01 00:00:00

abstract：:A controlled graded bleeding was performed in conscious rats with 15 min intervals between two withdrawals, in order to induce a 25% blood loss without hypotension. Heart rate (HR) was unaffected as well. The spectral profiles of systolic blood pressure (SBP) analyzed on 51.2 s segments exhibited increases in the high...

journal_title：Fundamental & clinical pharmacology

authors： Baujard C,Ponchon P,Elghozi JL

更新日期：1996-01-01 00:00:00

abstract：:The ATP-binding cassette (ABC) transporter ABCB1, or P-glycoprotein, is a transmembrane efflux pump well known for its implication in drug transport and chemoresistance. ABCB1 substrates include either drugs, such as antiretrovirals and immunomodulators, or physiological molecules like phospholipids. Pharmacogenetic a...

journal_title：Fundamental & clinical pharmacology

authors： Jeannesson E,Albertini L,Siest G,Gomes AM,Ribeiro V,Aslanidis C,Schmitz G,Visvikis-Siest S

更新日期：2007-08-01 00:00:00

abstract：:The effects of a new transdermal delivery system for clonidine (M-5041T) on hypotensive effect, urine volume, plasma renin activity (PRA) and antidiuretic hormone (ADH) in spontaneously hypertensive rats (SHRs) were compared to the effects of the continuous infusion of clonidine. Both M-5041T (1.5 and 4.5 mg/kg) and t...

journal_title：Fundamental & clinical pharmacology

authors： Naruse T,Ishida T,Ishii R,Tagawa T

更新日期：1996-01-01 00:00:00

abstract：:Lithium causes erectile dysfunction in patients but its mechanism is yet unknown. The aim of our study was to verify the effect of acute lithium administration on the nonadrenergic noncholinergic (NANC)- and endothelium-mediated relaxation of guinea pig isolated corpus cavernosum. Although lithium (0.5, 1, and 5mm) ha...

journal_title：Fundamental & clinical pharmacology

authors： Ghasemi M,Farrokhi-Khajeh-Pasha Y,Ostovaneh MR,Dehpour AR

更新日期：2011-04-01 00:00:00

abstract：:Methodology used for the development of anti-Alzheimer's disease (AD) drugs raises specific problems which are rarely examined in the literature. While the general development scheme is similar to that required for most drugs, some specific aspects must be analyzed, highly dominated by the dual goal of pharmacology, i...

journal_title：Fundamental & clinical pharmacology

authors： Allain H,Bentué-Ferrer D,Zekri O,Schück S,Lebreton S,Reymann JM

更新日期：1998-01-01 00:00:00

abstract：:Rats of the Fischer 344 (F344) and Wistar Kyoto (WKY) strains are known to present differences in stimuli responses involving the renin-angiotensin system and in cardiovascular responses to an acoustic startle stimulus. Here we compared the vascular reactivity to angiotensin II (ANG II) of these normotensive, inbred r...

journal_title：Fundamental & clinical pharmacology

authors： Herin L,Blanc J,Basset A,Laude D,Laurent S,Elghozi JL

更新日期：2003-06-01 00:00:00

abstract：:Oxidized low density lipoprotein (ox-LDL) and lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) have been implicated in the development of atherosclerosis. This study was designed to investigate the expression regulation of LOX-1 by ox-LDL and the potential underlying mechanisms in cultured rat vascular ...

journal_title：Fundamental & clinical pharmacology

authors： Sun Y,Chen X

更新日期：2011-10-01 00:00:00

abstract：:Potentiation of opioid analgesia by endothelin-A (ET(A)) receptor antagonist, BMS182874, and imidazoline receptor/α₂-adrenoceptor agonists such as clonidine and agmatine are well known. It is also known that agmatine blocks morphine hyperthermia in rats. However, the effect of agmatine on morphine or oxycodone hypothe...

journal_title：Fundamental & clinical pharmacology

authors： Bhalla S,Andurkar SV,Gulati A

更新日期：2013-10-01 00:00:00

abstract：:The effects of nifedipine and nicardipine, 2 dihydropyridines (DHP) used in the treatment of cardiovascular disorders, were compared in frog atrial fibers. Rapid photolysis of nifedipine with a single UV flash (1-ms duration) reversed the block, allowing comparison of effects of both drugs on the same preparation, and...

journal_title：Fundamental & clinical pharmacology

authors： Charnet P,Ouadid H,Richard S,Nargeot J

更新日期：1987-01-01 00:00:00

abstract：:We used two validated psychopharmacological methods, the forced swimming test (FST 20 min and 5 min) and the elevated plus-maze (EPM), to quantify depression-like and anxiety-like behavior induced by transient global cerebral ischemia in the rat. We also validated use of these methods for the study of antidepressant (...

journal_title：Fundamental & clinical pharmacology

authors： Bantsiele GB,Bentué-Ferrer D,Amiot N,Allain H,Bourin M,Reymann JM

更新日期：2004-12-01 00:00:00

abstract：:Pyroglutamic acid (PCA) was compared with placebo in a randomized, double blind trial for assessing its efficacy in treating memory deficits in 40 aged subjects. Twenty subjects were treated with PCA and 20 with placebo over a period of 60 d. Memory functions were evaluated at baseline and after 60 d of treatment by m...

journal_title：Fundamental & clinical pharmacology

authors： Grioli S,Lomeo C,Quattropani MC,Spignoli G,Villardita C

更新日期：1990-01-01 00:00:00

abstract：:A combination of sub-effective doses of thioperamide (7.5 mg/kg, i.p.) and tacrine (0.5 mg/kg, i.p.) enhanced performance in a spatial memory task in mice. This was shown by a significant increase in their spontaneous alternation scores in a cross maze test. ...

journal_title：Fundamental & clinical pharmacology

authors： Vohora D,Pal SN,Pillai KK

更新日期：2005-10-01 00:00:00

abstract：:A new quinoline containing selenium, 4-phenylselenyl-7-chloroquinoline (4-PSQ), was described and synthetized by our research group. Recently, we demonstrated the potential antinociceptive and anti-inflammatory of 4-PSQ. For this reason, the first objective of this study was to expand our previous findings by investig...

journal_title：Fundamental & clinical pharmacology

authors： Silva VDG,Reis AS,Pinz MP,da Fonseca CAR,Duarte LFB,Roehrs JA,Alves D,Luchese C,Wilhelm EA

更新日期：2017-10-01 00:00:00

abstract：:The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60-min and then reperfused for 48-h. P...

journal_title：Fundamental & clinical pharmacology

authors： Létienne R,Bel L,Bessac AM,Denais D,Degryse AD,John GW,Le Grand B

更新日期：2006-04-01 00:00:00

abstract：:The involvement of radical reactions in the ageing process, physiological as well as pathological, is well demonstrated. It is accepted that alloxan cyto-toxicity is linked to a production of hydroxylated free radicals and that a substance preventing the development of alloxanic diabetes possesses scavenger properties...

journal_title：Fundamental & clinical pharmacology

authors： Bentue-Ferrer D,Philouze V,Pape D,Reymann JM,Allain H,Van den Driessche J

更新日期：1989-01-01 00:00:00

abstract：:Some combinations of antihypertensive agents were shown to reduce proteinuria in patients with renal failure. However, preventive effects of such combinations on renal structure and function are presently unknown when treatment is administered before the onset of renal abnormalities. We thus investigated the long-term...

journal_title：Fundamental & clinical pharmacology

authors： Renaud IM,Chainey A,Belair MF,Mandet C,Michel O,Myara I,Chevalier J,Plante GE

更新日期：2004-08-01 00:00:00

abstract：:To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected sample of medical wards in public hospitals between December 2006 and June 2007; all patients adm...

journal_title：Fundamental & clinical pharmacology

authors： Bénard-Laribière A,Miremont-Salamé G,Pérault-Pochat MC,Noize P,Haramburu F,EMIR Study Group on behalf of the French network of pharmacovigilance centres.

更新日期：2015-02-01 00:00:00

abstract：:Cicletanine, a racemic furopyridine derivative synthesized as racemate, is used as an antihypertensive agent. Its two enantiomers are involved in the pharmacological effects of the drug. Cicletanine is metabolized by conjugation enzyme systems (phase II) into sulfoconjugated or glucuroconjugated enantiomers. As oxazep...

journal_title：Fundamental & clinical pharmacology

authors： Menard C,Lamiable D,Vistelle R,Droy-Lefait MT,Ratanasavanh D

更新日期：1999-01-01 00:00:00

abstract：:This paper reviews state-of-art statistical designs for dose-escalation procedures in first-into-man studies. The main focus will be on studies in oncology, as most statistical procedures for phase I trials have been proposed in this context. Extensions to situations such as the observation of bivariate outcomes and h...

journal_title：Fundamental & clinical pharmacology

authors： Zhou Y

更新日期：2004-06-01 00:00:00

abstract：:Gastric mucosa is frequently exposed to various gastric irritants, and there is a continuing requirement to develop new gastro-protective agents. This study compares the effects of three such agents, sucralfate, rebamipide, and cimetidine in both in vivo and in vitro indomethacin-induced gastric damage models. For the...

journal_title：Fundamental & clinical pharmacology

authors： Goineau S,Castagné V

更新日期：2017-04-01 00:00:00

abstract：:Ponsinomycin is a new macrolide antibiotic. Its effect on DHE pharmacokinetics was investigated in this study. Twelve young healthy volunteers received a single 9 mg oral dose of DHE before and on the 8th day of treatment (800 mg twice daily) with ponsinomycin. DHE was assayed in plasma by RIA. Because of low plasma l...

journal_title：Fundamental & clinical pharmacology

authors： Couet W,Mathieu HP,Fourtillan JB

更新日期：1991-01-01 00:00:00

abstract：:Adrenoceptors are involved in the control of the activity of the autonomic nervous system and especially the sympathetic nervous system. Activation of alpha 2-adrenoceptors decreases sympathetic tone whereas their blockade has an opposite effect. However, previous investigations have shown that yohimbine (a potent alp...

journal_title：Fundamental & clinical pharmacology

authors： Bagheri H,Chale JJ,Guyen LN,Tran MA,Berlan M,Montastruc JL

更新日期：1995-01-01 00:00:00

abstract：:We investigated the implication of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in the proliferation stimulated by angiotensin II (Ang II) and endothelin-1 (ET-1) in cultured rabbit gingival fibroblasts (CRGF). Ang II stimulated activation of ERK1/2 and the activation was inhibited by CV-11974, an A...

journal_title：Fundamental & clinical pharmacology

authors： Ohsawa M,Ohuchi N,Taniguchi Y,Kizawa Y,Koike K,Iwamoto K,Hayashi K,Murakami H

更新日期：2005-12-01 00:00:00

abstract：:The third generation aromatase inhibitors are currently the drugs of choice for the treatment of early and advanced breast cancer in postmenopausal women. One of the significant limiting factor during therapy is their negative impact on bone health. In this study, we compared the effects of a nonsteroidal (letrozole) ...

journal_title：Fundamental & clinical pharmacology

authors： Kalam A,Talegaonkar S,Vohora D

更新日期：2016-10-01 00:00:00

abstract：:The effects of Ketotifen and disodium cromoglycate were investigated on human and rabbit platelet activation. Ketotifen inhibited dose-dependently human and rabbit platelet aggregation. The paf-acether pathway was the most markedly influenced by Ketotifen in human and rabbit platelets (IC50 = 38.8 +/- 7.7 microM and 7...

journal_title：Fundamental & clinical pharmacology

authors： Devillier P,Arnoux B,Lalau Keraly C,Landes A,Marsac J,Benveniste J

更新日期：1990-01-01 00:00:00

abstract：:The effect known as the GTP-shift refers to the complete conversion of receptors from the high- to the low agonist-affinity state in the presence of an excess of GTP or one of its analogs. 5'-Guanylylimidodiphosphate (GppNHp) was able to fully suppress the high (-)-isoproterenol-affinity of beta-adrenoceptors (beta AR...

journal_title：Fundamental & clinical pharmacology

authors： Garnier V,Zini R,Tillement JP

更新日期：1999-01-01 00:00:00