Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice.

abstract：:Oxidative stress and associated complications are the major pathological concerns of diabetic cardiomyopathy (DC). We aim to elucidate the mechanisms by which high glucose (HG) induced alteration in calcium homeostasis and evaluation of the beneficial effect of two concentrations (10 and 25 μm) of ferulic acid (FA). H...

journal_title：Fundamental & clinical pharmacology

authors： Salin Raj P,Swapna SUS,Raghu KG

更新日期：2019-08-01 00:00:00

abstract：:Patients with rheumatoid arthritis (RA) appear to have increased plasma levels of leptin and adiponectin. These adipokines may be implicated in the pathophysiology of RA. Tumour necrosis factor alpha (TNF-alpha) is a potential modulator of adipokines. The effects of long-term anti-TNF treatment on plasma levels of lep...

journal_title：Fundamental & clinical pharmacology

authors： Derdemezis CS,Filippatos TD,Voulgari PV,Tselepis AD,Drosos AA,Kiortsis DN

更新日期：2009-10-01 00:00:00

abstract：:Thienopyridines have become the cornerstone of treatment for percutaneous coronary intervention although no survival benefit has ever been shown with clopidogrel despite increasing loading doses. Newly developed P2Y12 inhibitors are more potent, more predictable, and have a faster onset of action than clopidogrel, cha...

journal_title：Fundamental & clinical pharmacology

authors： Collet JP,O'Connor S

更新日期：2012-02-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) injections of dihydropyridine derivatives calcium channel agonist (BAY K8644) and antagonist (nifedipine, nicardipine, PN 200-110) induced opposite long-lasting changes in blood pressure (BP) in pentobarbital anesthetized spontaneously hypertensive rats (SMR). I.c.v. nifedipine (NIF), ...

journal_title：Fundamental & clinical pharmacology

authors： Laurent S,Brisac AM,Champeroux P,Lacolley P,Huguet F,Legrand M,Lucet B,Tsoucaris D,Briand V,Schmitt H

更新日期：1989-01-01 00:00:00

abstract：:HMG CoA reductase inhibitors (statins) have an established place in the treatment of coronary artery disease. However, their role in the treatment of heart failure (HF), including HF due to coronary artery disease, has been controversial since beneficial as well as possible harmful effects may occur. Several recent st...

journal_title：Fundamental & clinical pharmacology

authors： Gullestad L,Oie E,Ueland T,Yndestad A,Aukrust P

更新日期：2007-11-01 00:00:00

abstract：:Vitamin K1 injection induces severe dose-related anaphylactoid reactions and overdose for the treatment of vitamin K deficiency. We aimed to find an optimal and small dose of vitamin K1 injection to treat vitamin K deficiency and avoid anaphylactoid reactions in animal. Rats were administered a vitamin K-deficient die...

journal_title：Fundamental & clinical pharmacology

authors： Mi YN,Ping NN,Li B,Xiao X,Zhu YB,Cao L,Ren JK,Cao YX

更新日期：2017-10-01 00:00:00

abstract：:This systematic review analyses the efficacy, tolerability and safety of combinations of different medicines used to treat dyslipidemias in clinical practice. A PubMed search up to January 2009, was conducted to identify relevant studies. Criteria used to identify studies included (1) English language, (2) published s...

journal_title：Fundamental & clinical pharmacology

authors： Reiner Z

更新日期：2010-02-01 00:00:00

abstract：:The anticonvulsant effect of compounds that inhibit peptidyl-dipeptidase (PDP) on bicuculline (BIC)- and strychnine (STRYC)-induced seizures was assessed after intracerebroventricular (ICV) or intraperitoneal (IP) administration in Swiss albino mice. STRYC-induced seizures were delayed by ICV injections and high IP do...

journal_title：Fundamental & clinical pharmacology

authors： Miñano FJ,Serrano JS,Sancibrián M,Serrano MI

更新日期：1987-01-01 00:00:00

abstract：:The smooth muscle relaxant responses to NS-004, an activator of charybdotoxin-sensitive, large conductance Ca(2+)-dependent K+ channels (BKCa) were studied on the basal spontaneous tone in guinea-pig trachea in vitro. The sensitivity of these responses to a range of K+ channel inhibitors and antagonists were also eval...

journal_title：Fundamental & clinical pharmacology

authors： Lawson K,Barras M,Armstrong JM,Hicks PE

更新日期：1997-01-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a persisting challenge to clinical and basic research scientists as none of the presently available medications have been fully able to combat these consequences. The aim of the present review is to summarize the different lines of treatment available for the different symptomologie...

journal_title：Fundamental & clinical pharmacology

authors： Saha L,Kaur S,Saha PK

更新日期：2012-02-01 00:00:00

abstract：:In addition to their direct effects on cardiac contractility, a number of positive inotropic agents also induce, through direct peripheral vasodilation, a reduction in afterload which is of major importance in their beneficial effects in the treatment of congestive heart failure. However, the induced increase in cardi...

journal_title：Fundamental & clinical pharmacology

authors： Gosgnach M,Gérard JL,Berdeaux A,Giudicelli JF

更新日期：1991-01-01 00:00:00

abstract：:Allopurinol, oxypurinol, hypoxanthine and xanthine were assayed simultaneously using a highly specific method combining gas chromatography and mass spectrometry. Two hypo-uricaemic prescriptions were compared: i) 300 mg of allopurinol (AL); and ii) 100 mg of allopurinol plus 20 mg of benzbromarone (AL + BZB). When adm...

journal_title：Fundamental & clinical pharmacology

authors： Lartigue-Mattei C,Chabard JL,Ristori JM,Bussiere JL,Bargnoux H,Petit J,Berger JA

更新日期：1991-01-01 00:00:00

abstract：:Pyroglutamic acid (PCA) was compared with placebo in a randomized, double blind trial for assessing its efficacy in treating memory deficits in 40 aged subjects. Twenty subjects were treated with PCA and 20 with placebo over a period of 60 d. Memory functions were evaluated at baseline and after 60 d of treatment by m...

journal_title：Fundamental & clinical pharmacology

authors： Grioli S,Lomeo C,Quattropani MC,Spignoli G,Villardita C

更新日期：1990-01-01 00:00:00

abstract：:The action of ouabain, a cell membrane Na+, K+-ATPase blocker, on contractions induced by manganese ions (Mn2+) in Ca2+-free, isotonic solutions with varying concentrations of K+ in the external medium were investigated in order to evaluate the underlying role of external Na+ in Mn2+-induced contractions in isolated t...

journal_title：Fundamental & clinical pharmacology

authors： Nasu T,Takahashi K

更新日期：2005-06-01 00:00:00

abstract：:The aim of this analysis was to compare vasoreactive properties of internal thoracic arteries (ITA) grafts from diabetic (DM) to those of non-diabetic (ND) patients. Ring segments of ITA, taken from patients undergoing coronary artery bypass grafting, were suspended in organ bath chambers filled with modified Krebs-He...

journal_title：Fundamental & clinical pharmacology

authors： Grapow MT,Reineke DC,Kern T,Müller-Schweinitzer E,Carrel T,Eckstein FS

更新日期：2009-10-01 00:00:00

abstract：:In this review, the major enzyme systems involved in vivo in the oxidative metabolism of xenobiotic amines in humans are discussed, i.e. the monooxygenases [cytochrome P450 system (CYPs) and flavin-containing monooxygenases (FMOs)] and the amine oxidases (AOs). Concerning the metabolism of xenobiotic amines (drugs in ...

journal_title：Fundamental & clinical pharmacology

authors： Strolin Benedetti M,Tipton KF,Whomsley R

更新日期：2007-10-01 00:00:00

abstract：:Free radical species have been implicated as important agents involved in myocardial ischemic and reperfusion injuries. Superoxide is capable of mobilizing iron from ferritin and the released iron can cause hydroxyl formation from H2O2. The aim of this study was to evaluate the time-dependent increase in lipid peroxid...

journal_title：Fundamental & clinical pharmacology

authors： Cottin Y,Doise JM,Maupoil V,Tannière-Zeller M,Dalloz F,Maynadié M,Walker MK,Louis P,Carli PM,Wolf JE,Rochette L

更新日期：1998-01-01 00:00:00

abstract：:We used two validated psychopharmacological methods, the forced swimming test (FST 20 min and 5 min) and the elevated plus-maze (EPM), to quantify depression-like and anxiety-like behavior induced by transient global cerebral ischemia in the rat. We also validated use of these methods for the study of antidepressant (...

journal_title：Fundamental & clinical pharmacology

authors： Bantsiele GB,Bentué-Ferrer D,Amiot N,Allain H,Bourin M,Reymann JM

更新日期：2004-12-01 00:00:00

abstract：:In experiments in vivo, we studied whether the endothelial dysfunction induced by nitric oxide (NO) synthesis inhibition is simultaneously or sequentially manifested as a reduced level of endothelium-dependent agonist-induced vasodilatation, an increased responsiveness to vasoconstrictors, and hypertension. Vascular r...

journal_title：Fundamental & clinical pharmacology

authors： López RM,Pérez T,Castillo C,Castillo MC,Castillo EF

更新日期：2011-06-01 00:00:00

abstract：:Clinical and experimental studies have shown that gender differences exist in cardiac repolarization in various animal species and human, as is evidenced by significantly longer QT, JT intervals and action potential duration in females than in males due to a reduced repolarization reserve in females. The latter is sho...

journal_title：Fundamental & clinical pharmacology

authors： Cheng J

更新日期：2006-02-01 00:00:00

abstract：:Excessive daytime sleepiness (EDS) has been reported with many drugs, either as an extension of a hypnotic effect (e.g. central nervous system depressants) or as an idiosyncratic response of the patient. Here, we report unexpected and severe subjective and objective EDS induced by hydroxyurea therapy, with a favorable...

journal_title：Fundamental & clinical pharmacology

authors： Revol B,Joyeux-Faure M,Albahary MV,Gressin R,Mallaret M,Pepin JL,Launois SH

更新日期：2017-06-01 00:00:00

abstract：:During the last decade, a multitude of experimental arguments have led to the concept that EDRF is nitric oxide (NO), a messenger not only involved in the control of vasomotor tone but also in vascular homeostasis, neuronal and immunological functions. Regardless of its origin, endogenous NO is produced through the co...

journal_title：Fundamental & clinical pharmacology

authors： Berdeaux A

更新日期：1993-01-01 00:00:00

abstract：:Although nisoxetine has been shown to elicit cutaneous (peripheral) anesthesia, spinal (central) anesthesia with nisoxetine was not exposed. The aim of this study was to examine spinal anesthesia of nisoxetine and its influence on the antinociceptive action of mepivacaine. We compared nisoxetine with an established lo...

journal_title：Fundamental & clinical pharmacology

authors： Leung YM,Chu CC,Kuo CS,Chen YW,Hung CH,Wang JJ

更新日期：2014-02-01 00:00:00

abstract：:Gastric mucosa is frequently exposed to various gastric irritants, and there is a continuing requirement to develop new gastro-protective agents. This study compares the effects of three such agents, sucralfate, rebamipide, and cimetidine in both in vivo and in vitro indomethacin-induced gastric damage models. For the...

journal_title：Fundamental & clinical pharmacology

authors： Goineau S,Castagné V

更新日期：2017-04-01 00:00:00

abstract：:Endocannabinoid system has attracted the researchers to investigate into its ever fascinating roles governing many of the physiological functions in the human body. The prime endogenous cannabinoids are arachidonoylethanolamide also called anandamide and 2-arachidonoylglycerol. Recent pharmacological advances point ou...

journal_title：Fundamental & clinical pharmacology

authors： Smita K,Sushil Kumar V,Premendran JS

更新日期：2007-02-01 00:00:00

abstract：:The ATP-binding cassette (ABC) transporter ABCB1, or P-glycoprotein, is a transmembrane efflux pump well known for its implication in drug transport and chemoresistance. ABCB1 substrates include either drugs, such as antiretrovirals and immunomodulators, or physiological molecules like phospholipids. Pharmacogenetic a...

journal_title：Fundamental & clinical pharmacology

authors： Jeannesson E,Albertini L,Siest G,Gomes AM,Ribeiro V,Aslanidis C,Schmitz G,Visvikis-Siest S

更新日期：2007-08-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is a new immunosuppressive drug used to reduce acute rejection after heart transplantation. As with other immunosuppressive drugs, MMF therapy is associated with several adverse effects. However, the direct effects of MMF on myocardial tissue has not been yet evaluated. The aim of the work ...

journal_title：Fundamental & clinical pharmacology

authors： Bès S,Tatou E,Vandroux D,Tissier C,Rochette L,Athias P

更新日期：2004-06-01 00:00:00

abstract：:The aim of the present study was to assess the role of vascular alpha 1D-adrenoceptors in the sympathetic vasopressor response in vivo. Specifically, we evaluated the effect of a selective alpha 1D-adrenoceptor antagonist, BMY 7378 (8-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-8-azaspiro(4,5)dec ane-7,9- dione 2HCl)...

journal_title：Fundamental & clinical pharmacology

authors： Castillo EF,López RM,Rodríguez-Silverio J,Bobadilla RA,Castillo C

更新日期：1998-01-01 00:00:00

abstract：:Methodology used for the development of anti-Alzheimer's disease (AD) drugs raises specific problems which are rarely examined in the literature. While the general development scheme is similar to that required for most drugs, some specific aspects must be analyzed, highly dominated by the dual goal of pharmacology, i...

journal_title：Fundamental & clinical pharmacology

authors： Allain H,Bentué-Ferrer D,Zekri O,Schück S,Lebreton S,Reymann JM

更新日期：1998-01-01 00:00:00

abstract：:Drugs have side effects that manifest as signs or symptoms which are sometimes undistinguishable from signs or symptoms of active disease. The conventional approximation of the rate of side effects of drugs is by subtracting the rate of signs and symptoms in the placebo group from that in the drug group. This measures...

journal_title：Fundamental & clinical pharmacology

authors： Bernheim JL,Vrana I

更新日期：1995-01-01 00:00:00