Tocolytic and hemodynamic effects of nifedipine in the ewe.

Abstract:

:The ability of the calcium antagonist nifedipine to inhibit uterine contractions during labor and in the postpartum period was measured in the ewe. The hemodynamic effects of tocolytic doses of this drug were measured and compared with the hemodynamic effects of equivalent doses of ritodrine. Intravenous nifedipine was found to be a potent tocolytic agent that completely inhibited uterine activity even in advanced labor when administered at infusion rates that resulted in only mild hemodynamic effects. At tocolytically similar infusion rates nifedipine produced significantly less increase in maternal heart rate than did ritodrine.

journal_name

Am J Obstet Gynecol

authors

Golichowski AM,Hathaway DR,Fineberg N,Peleg D

doi

10.1016/0002-9378(85)90397-7

subject

Has Abstract

pub_date

1985-04-15 00:00:00

pages

1134-40

issue

8

eissn

0002-9378

issn

1097-6868

pii

0002-9378(85)90397-7

journal_volume

151

pub_type

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