Abstract:
:Despite significant improvements, current therapies have yet to cure infiltrative gliomas. Glioma progression is strongly dependent on the development of a new vascular network that occurs primarily by angiogenesis. Hypoxia and genetic anomalies within a glioma trigger the angiogenic switch, thus upregulating angiogenic factors and downregulating antiangiogenic factors. The main factors indicative of angiogenesis are now well known, and more recently, differences based on grade and subtype have been reported. New data also indicate a potential role for postnatal vasculogenesis with bone marrow endothelial progenitors in addition to angiogenesis in tumor vascular development. All of these factors may have therapeutic implications. Antiangiogenic therapies are presently being developed; more than 80 trials are ongoing. Initial results indicate that epidermal growth factor receptor inhibitors, anti-metalloproteases, and thalidomide do not demonstrate strong anti-tumor activity. Thus, antiangiogenic agents combined with conventional therapies and second-generation antiangiogenic drugs for targeting multiple molecular pathways are presently being tested. Clinical experience also demonstrates the failure of conventional imaging to monitor these new approaches accurately. New advances in the design of surrogate markers for angiogenesis have been reported for both magnetic resonance and molecular imaging techniques. This article summarizes the mechanisms of the angiogenic switch based on tumor grade and subtype, reviews completed and ongoing clinical trials, and details the present and the future of surrogate markers for angiogenesis in gliomas.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Jouanneau Edoi
10.1227/01.NEU.0000311060.65002.4Esubject
Has Abstractpub_date
2008-01-01 00:00:00pages
31-50; discussion 50-2issue
1eissn
0148-396Xissn
1524-4040pii
00006123-200801000-00003journal_volume
62pub_type
杂志文章,评审相关文献
NEUROSURGERY文献大全abstract:OBJECTIVE:To examine the incidence and possible determinants of impaired vascular reserve in arteriovenous malformation (AVM)-affected brain, before and after surgery. METHODS:In a prospective study of 30 patients, the regional cerebrovascular reserve capacity (rCRC) and the vasodilated regional cerebral blood flow (r...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200104000-00001
更新日期:2001-04-01 00:00:00
abstract:INTRODUCTION:Isolated spinal aneurysms are rare; only a few have been reported. To the best of our knowledge, this series represents the largest experience with four ruptured spinal aneurysms, all of which were treated surgically. METHODS:Clinical information from the hospital charts and diagnostic images of four pati...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000186010.34779.10
更新日期:2005-12-01 00:00:00
abstract::The management of 15 cases of bilateral locked facets of the cervical spine is reviewed. The C-6, C-7 interspace was the most common interspace involved. There were 4 females and 11 males who were 16 to 63 years old (average, 26 years). Thirteen patients had a complete spinal cord lesion with loss of function below th...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198102000-00002
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Heat transfer from bipolar tips to adjacent tissue presents a risk of thermal injury during spine surgery. OBJECTIVE:The present study was designed to determine wither bipolar forceps using a novel heat pipe thermal regulation technology resulted in decreased collateral thermal injury of adjacent tissue com...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000370246.82005.6f
更新日期:2010-07-01 00:00:00
abstract::The surgical approaches to the cavernous sinus were examined in 50 adult cadaveric cavernous sinuses using magnification of X3 to X40. The following approaches were examined: 1) the superior intradural approach directed through a frontotemporal craniotomy and the roof of the cavernous sinus; 2) the superior intradural...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199006000-00001
更新日期:1990-06-01 00:00:00
abstract::The aim of the present study was to evaluate the influence of previous treatment on outcome and sensory disturbance after a retrogasserian glycerol injection for trigeminal neuralgia. Ninety-nine patients with trigeminal neuralgia underwent a retrogasserian glycerol rhizotomy. Fifty-three of those patients experienced...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199502000-00009
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVE:Recent findings have cast doubt on vasospasm as the sole cause of delayed cerebral ischemia after subarachnoid hemorrhage. METHODS:We reviewed the medical records of 29 patients who died after subarachnoid hemorrhage. Brain sections were taken from the insula, cingulate gyrus, and hippocampus. Adjacent secti...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000227519.27569.45
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:To audit the reliability of the Camino intracranial pressure (ICP) sensor (Camino Laboratories, San Diego, CA) in our clinical practice as part of a continuing quality assurance program, and to assess its relative usefulness as compared with currently available ICP monitoring technologies that we reviewed. D...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200111000-00026
更新日期:2001-11-01 00:00:00
abstract::In a prospective study on the effect of shunting, 22 patients diagnosed as suffering from normal pressure hydrocephalus (NPH) were investigated by means of temporary external lumbar drainage (ELD). Five patients had to be excluded from the study because of complications of ELD or definitive shunting. ELD correctly pre...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198802000-00020
更新日期:1988-02-01 00:00:00
abstract::A rare case of primary spinal intramedullary malignant melanoma at the T6 level in a 31-year-old man is presented. The tumor was partially removed, and neuroaxis irradiation up to 50 Gy was then administered. Subsequently, systemic interferon beta (specific activity, 2.0 X 10(8) IU/mg protein) therapy (total dose, 2.2...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-198907000-00023
更新日期:1989-07-01 00:00:00
abstract::Between June 1979 and May 1994, I performed 148 unilateral or bilateral sympathectomies on 247 limbs in 110 patients using a percutaneous radiofrequency technique, usually on an outpatient surgery basis. Patient ages ranged from 10 to 81 years, with 45 male and 65 female patients. Four patients had unsuccessfully unde...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:We describe a patient with a tentorial dural arteriovenous fistula who presented with ipsilateral hemifacial spasm. CLINICAL PRESENTATION:A 50-year-old man sought treatment for left facial twitching that worsened over 6 months. Magnetic resonance imaging and catheter angiography demonstrated a...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000192386.89105.82
更新日期:2006-01-01 00:00:00
abstract::From 1978 to 1988, 314 patients with malignant astrocytoma were treated by our neuro-oncology team. Twenty-five patients were excluded from further analysis because of a lack of adequate follow-up, the brain-stem location of the tumor, or an age of less than 18 years. Of the 289 remaining patients in the valid study g...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199402000-00002
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVE:Recently, several studies suggested that simple decompression is as effective as anterior transposition in ulnar nerve entrapment syndrome. Simple decompression might be performed with minimally invasive techniques. The authors present their technique and results with endoscopic decompression in ulnar nerve e...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000367551.41503.58
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To review our experience of managing idiopathic normal pressure hydrocephalus (iNPH) during the 6-year period from 2002 to 2007, when intracranial pressure (ICP) monitoring was part of the diagnostic workup. METHODS:The review includes all iNPH patients undergoing diagnostic ICP monitoring during the years 2...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/01.NEU.0000363408.69856.B8
更新日期:2010-01-01 00:00:00
abstract::To elucidate the factors associated with functional recovery after traumatic transtentorial herniation, we reviewed the records of 153 consecutive patients admitted with clinical signs of transtentorial herniation (altered level of consciousness, anisocoria or pupillary unresponsiveness, and abnormal motor findings). ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199108000-00010
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVE:Arteriovenous malformations (AVMs) involving the cerebellum and brainstem are relatively rare lesions that most often present clinically as a result of a hemorrhagic episode. Although these AVMs were once thought to have a more aggressive clinical course in comparison with supratentorial AVMs, recent autopsy ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000204641.38419.2D
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To study the cerebral metabolism and its relationship to cerebral blood flow (CBF) acutely after subarachnoid hemorrhage (SAH). METHODS:SAH was induced in rats by endovascular perforation of the internal carotid artery, blood injection into the prechiasmatic cistern or the cisterna magna. CBF (measured by la...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000103670.09687.7a
更新日期:2004-02-01 00:00:00
abstract::This report describes a computed tomography-based computer-assisted stereotactic technique for performing 3rd ventriculostomy. The procedure has been performed on seven patients with acquired obstructive hydrocephalus of various etiologies. None of these patients have yet required shunting. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198606000-00021
更新日期:1986-06-01 00:00:00
abstract:OBJECTIVE:This Phase I trial of ciliary neurotrophic factor (CNTF) delivered intrathecally for the treatment of patients with amyotrophic lateral sclerosis was designed to determine the safety of this new mode of administration as well as the pharmacokinetics and drug distribution. METHODS:CNTF was administered using ...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1097/00006123-199701000-00021
更新日期:1997-01-01 00:00:00
abstract::Using rabbit cerebral arteries in an in vitro chamber, we examined the cerebral arterial contraction initiated by clotting whole blood. By using methysergide maleate and a novel thromboxane synthetase inhibitor, 1-carboxyheptylimidazole (1-CHI), we studied the contributions of both serotonin and the prostaglandin meta...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1981-09-01 00:00:00
abstract::The authors report their experience with experimental brain vascularization with the use of transplanted omentum majus. The possibility of treating cerebral ischemia with this method is discussed. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-197711000-00006
更新日期:1977-11-01 00:00:00
abstract:OBJECTIVE:To determine the understanding of the conceptual basis and diagnostic tests used for brain death (BD) by neurosurgeons in Canada. METHODS:Between February and June 2006, a previously developed survey was mailed to every neurosurgeon in Canada. RESULTS:Of 223 surveys mailed, 147 (66%) were returned; of these...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000303200.84994.ae
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:Iron catalyzed generation of injurious free radicals has been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). The present study assessed the effects of the iron chelator deferiprone on cerebral vasospasm in an in vivo rabbit model of SAH. METHODS:Twenty-four rabbits ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199712000-00028
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Posttraumatic seizure (PTS) is a significant complication of traumatic brain injury (TBI). OBJECTIVE:To perform a systematic review and meta-analysis to compare levetiracetam with phenytoin for seizure prophylaxis in patients diagnosed with severe TBI. METHODS:An inclusive search of several electronic data...
journal_title:Neurosurgery
pub_type: 杂志文章,meta分析,评审
doi:10.1227/NEU.0000000000001445
更新日期:2016-12-01 00:00:00
abstract::Toxic epidermal necrolysis is a rare but often fatal hypersensitivity reaction to numerous agents, including most anticonvulsants. The authors present a case of fatal phenytoin-related toxic epidermal necrolysis in a patient who was given prophylactic anticonvulsant therapy after he sustained a moderately severe close...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-198912000-00022
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:Free-hand insertion of an external ventricular drain (EVD) is a common emergency neurosurgical procedure, mostly performed for critically ill patients. Although EVD complications have been studied thoroughly, the accuracy of EVD positioning has been audited only occasionally. METHODS:Post-EVD insertion compu...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000356973.39913.0B
更新日期:2009-12-01 00:00:00
abstract::Samples of ventricular cerebrospinal fluid, tumor cyst fluid, and subdural fluid were obtained from 30 patients at operation. The protein concentration and the specific gravity of each sample were measured and the corresponding mean absorption numbers were calculated from the numerical printout of the preoperative com...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-197907010-00003
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:Achieving seizure control in patients with low-grade temporal lobe gliomas or glioneuronal tumors remains highly underappreciated, because seizures are the most frequent presenting symptom and significantly impact patient quality-of-life. OBJECTIVE:To assess how the extent of temporal lobe resection influen...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/NEU.0b013e31823c3a30
更新日期:2012-04-01 00:00:00
abstract::The authors present a case of the accidental puncture of a spinal ependymoma causing bleeding and an increase in the preexisting neurological deficits. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198505000-00016
更新日期:1985-05-01 00:00:00