Systemic administration of the iron chelator deferiprone attenuates subarachnoid hemorrhage-induced cerebral vasospasm in the rabbit.

Abstract:

OBJECTIVE:Iron catalyzed generation of injurious free radicals has been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). The present study assessed the effects of the iron chelator deferiprone on cerebral vasospasm in an in vivo rabbit model of SAH. METHODS:Twenty-four rabbits were assigned to three groups as follows: SAH plus placebo (n = 8), SAH plus deferiprone (n = 8), or control plus placebo (n = 8). Deferiprone was administered to an additional group of three rabbits that were not subjected to SAH. Drug administration was initiated 8 hours after SAH was induced and was repeated at 8-hour intervals. The animals were killed using perfusion-fixation 48 hours after SAH. Cross-sectional areas of basilar artery histological sections were measured by an investigator blinded to the treatment groups. RESULTS:In placebo-treated animals, the average luminal cross-sectional area of the basilar artery was reduced by 54% after SAH compared to controls (i.e., from 0.272 to 0.125 mm2). The vasospastic response after SAH was attenuated significantly in animals treated with deferiprone (0.208 mm2, representing a 24% reduction). CONCLUSION:Previous experimental studies suggested that iron chelation can be effective in attenuating cerebral vasospasm after SAH. Deferiprone is a recently developed iron chelator that has been extensively evaluated for the treatment of patients requiring chronic blood transfusions. The present study demonstrates that deferiprone is effective in attenuating experimental cerebral vasospasm. Because of its stability, lipophilicity, and ability to penetrate the blood-brain barrier, deferiprone represents an attractive candidate for the treatment of cerebral vasospasm.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Arthur AS,Fergus AH,Lanzino G,Mathys J,Kassell NF,Lee KS

doi

10.1097/00006123-199712000-00028

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

1385-91; discussion 1391-2

issue

6

eissn

0148-396X

issn

1524-4040

journal_volume

41

pub_type

杂志文章
  • Vestibular schwannomas: clinical results and quality of life after microsurgery or gamma knife radiosurgery.

    abstract:OBJECTIVE:The aim of the present study was to evaluate the overall treatment efficacy (tumor control, facial nerve function, complications) and quality of life for patients treated primarily for unilateral vestibular schwannomas of 30 mm or less, either by microsurgery or by gamma knife (GK) radiosurgery. The results f...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1055/s-2005-916493

    authors: Myrseth E,Møller P,Pedersen PH,Vassbotn FS,Wentzel-Larsen T,Lund-Johansen M

    更新日期:2005-05-01 00:00:00

  • Reflections on a stereotactic and functional journey: the blessing and inspiration of working among giants.

    abstract::The author reports some of his early personal neurosurgical experiences spent among some of the great figures in neurosurgery and among some of the founders and pioneers of functional neurosurgery, stereotaxy, and clinical neurophysiology during the mid-1960s. This historical vignette represents recognition of the leg...

    journal_title:Neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.1227/01.neu.0000146208.22449.54

    authors: Marino R Jr

    更新日期:2005-01-01 00:00:00

  • Continuous assessment of the cerebral vasomotor reactivity in head injury.

    abstract:OBJECTIVE:Cerebrovascular vasomotor reactivity reflects changes in smooth muscle tone in the arterial wall in response to changes in transmural pressure or the concentration of carbon dioxide in blood. We investigated whether slow waves in arterial blood pressure (ABP) and intracranial pressure (ICP) may be used to der...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199707000-00005

    authors: Czosnyka M,Smielewski P,Kirkpatrick P,Laing RJ,Menon D,Pickard JD

    更新日期:1997-07-01 00:00:00

  • Three-dimensional computed tomography-based spinal navigation in minimally invasive lateral lumbar interbody fusion: feasibility, technique, and initial results.

    abstract:BACKGROUND:As with most minimally invasive spine procedures, lateral lumbar interbody fusion (LLIF) requires the use of biplanar fluoroscopy for localization and safe interbody cage placement. Computed tomography (CT)-based intraoperative spinal navigation has been shown to be more effective than fluoroscopic guidance ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000726

    authors: Park P

    更新日期:2015-06-01 00:00:00

  • Evaluation of hydrocephalic periventricular radiolucency by dynamic computed tomography and xenon-computed tomography.

    abstract:OBJECTIVE:A common finding of computed tomography in a case of normal-pressure hydrocephalus (NPH) is periventricular radiolucency (PVL). We analyzed PVL for patients with hydrocephalus, using dynamic computed tomographic and xenon-computed tomographic techniques to differentiate NPH from similar diseases. METHODS:Dyn...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199610000-00023

    authors: Nakano H,Bandoh K,Miyaoka M,Sato K

    更新日期:1996-10-01 00:00:00

  • Transsphenoidal surgery for Cushing's disease: outcome in patients with a normal magnetic resonance imaging scan.

    abstract:OBJECTIVE:Transsphenoidal surgery for Cushing's disease from a pituitary adenoma is an effective and safe treatment. Definitive preoperative diagnosis of Cushing's disease caused by a pituitary adenoma is often difficult, particularly in patients with normal imaging studies and a normal sella turcica. We present the ou...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200003000-00005

    authors: Semple PL,Vance ML,Findling J,Laws ER Jr

    更新日期:2000-03-01 00:00:00

  • Neurotrophin 3 improves delayed reconstruction of sensory pathways after cervical dorsal root injury.

    abstract:BACKGROUND:Spinal root avulsion, or section, results in devastating functional sequels. Whereas reconstruction of motor pathways based on neurotization can reduce motor deficit, associated permanent limb anesthesia limits expected benefit. Sensory pathway reconstruction after dorsal root injury is limited by the inabil...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e318200512f

    authors: Liu S,Blanchard S,Bigou S,Vitry S,Bohl D,Heard JM

    更新日期:2011-02-01 00:00:00

  • International education: 20 years after implementation of a training program.

    abstract::Medical care in developing countries may be improved by various means. Advances in the medical education and training of specialists play an important role in improving health care systems. The results of the efforts of a neurosurgeon from North America who helped establish neurosurgical training in Taiwan are reporte...

    journal_title:Neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1097/00006123-200106000-00035

    authors: Lee ST

    更新日期:2001-06-01 00:00:00

  • Clinical clerkships in neurosurgery and neurology at United States medical schools.

    abstract::The neurology and neurosurgery clinical clerkship experience (excluding lectures and conferences) of the students in U.S. allopathic medical schools during one of the academic years 1986 to 1987 or 1987 to 1988 was surveyed. Almost all schools have at least some students taking these clerkships. The majority of studen...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199110000-00027

    authors: Lehman RA,Brodner RA,Greenblatt SH,Hirsh LF,Loeser J,Smith K,Curran L

    更新日期:1991-10-01 00:00:00

  • Can standard magnetic resonance imaging reliably distinguish recurrent tumor from radiation necrosis after radiosurgery for brain metastases? A radiographic-pathological study.

    abstract:OBJECTIVE:Stereotactic radiosurgery is a commonly used treatment method in the management of metastatic brain tumors. When lesions enlarge after radiosurgery, it may represent tumor regrowth, radiation necrosis, or both. The purpose of this study was to determine whether standard magnetic resonance imaging (MRI) sequen...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000333263.31870.31

    authors: Dequesada IM,Quisling RG,Yachnis A,Friedman WA

    更新日期:2008-11-01 00:00:00

  • A case of a spinal epidural capillary hemangioma: case report.

    abstract:BACKGROUND AND IMPORTANCE:Spinal hemangiomas usually arise from the vertebral body. Epidural hemangiomas are rare lesions, and most reported cases are cavernous. We report a case of a capillary hemangioma in the thoracic epidural space. CLINICAL PRESENTATION:The 57-year-old male patient initially presented with low th...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e3182093320

    authors: Hasan A,Guiot MC,Torres C,Marcoux J

    更新日期:2011-03-01 00:00:00

  • Femoral ring allograft for anterior cervical interbody fusion: technical note.

    abstract:OBJECTIVE:Cadaveric fibula with locking plate internal fixation has been reported to be associated with fewer complications and better long-term results, compared with autologous iliac crest. With the knowledge that cortically dense allografts collapse less with time, new machined femoral ring allografts were developed...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Shapiro S,Bindal R

    更新日期:2000-12-01 00:00:00

  • p53 in nonneoplastic central nervous system lesions: an immunohistochemical and genetic sequencing study.

    abstract:OBJECTIVE:Immunostaining for p53 commonly is considered a marker of neoplasia. Previous studies of nonneoplastic processes have yielded conflicting results. METHODS:To test the assumption that p53 immunoreactivity indicates neoplasia, we examined 60 formalin-fixed, paraffin-embedded biopsies of nonneoplastic central n...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200211000-00021

    authors: Kurtkaya-Yapicier O,Scheithauer BW,Hebrink D,James CD

    更新日期:2002-11-01 00:00:00

  • The silent loss of neuronavigation accuracy: a systematic retrospective analysis of factors influencing the mismatch of frameless stereotactic systems in cranial neurosurgery.

    abstract:BACKGROUND:Neuronavigation has become an intrinsic part of preoperative surgical planning and surgical procedures. However, many surgeons have the impression that accuracy decreases during surgery. OBJECTIVE:To quantify the decrease of neuronavigation accuracy and identify possible origins, we performed a retrospectiv...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e318287072d

    authors: Stieglitz LH,Fichtner J,Andres R,Schucht P,Krähenbühl AK,Raabe A,Beck J

    更新日期:2013-05-01 00:00:00

  • Computer-assisted interactive three-dimensional planning for neurosurgical procedures.

    abstract::We have used three-dimensional reconstruction magnetic resonance imaging techniques to understand the anatomic complexity of operative brain lesions and to improve preoperative surgical planning. We report our experience with 14 cases, including intra- and extra-axial tumors and a vascular malformation. In each case, ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Kikinis R,Gleason PL,Moriarty TM,Moore MR,Alexander E 3rd,Stieg PE,Matsumae M,Lorensen WE,Cline HE,Black PM,Jolesz FA

    更新日期:1996-04-01 00:00:00

  • Posterior fossa vascular anomaly presenting as a vermis mass in a 4-year-old child: diagnostic and therapeutic considerations.

    abstract::The computed tomographic (CT) scan has replaced angiography in the preoperative neurodiagnostic evaluation of the common pediatric posterior fossa tumors. This case report illustrates that rarely an atypical vascular anomaly may masquerade as a neoplasm and angiography must not be dismissed if the CT scan is any way a...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198006000-00011

    authors: Epstein N,Epstein F,Berenstein A

    更新日期:1980-06-01 00:00:00

  • No justification for cervical disk prostheses in clinical practice: a meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:A meta-analysis was performed to evaluate whether a beneficial clinical effect of cervical disk prostheses over conventional cervical diskectomy with fusion exists. METHODS:A literature search was completed ending February 4, 2009, that included the abstract books of recent major spine congresses. All studie...

    journal_title:Neurosurgery

    pub_type: 杂志文章,meta分析

    doi:10.1227/01.NEU.0000369189.09182.5F

    authors: Bartels RH,Donk R,Verbeek AL

    更新日期:2010-06-01 00:00:00

  • Microsurgical treatment of pediatric intracranial aneurysms: long-term angiographic and clinical outcomes.

    abstract:BACKGROUND:Pediatric aneurysms are rare and complex to treat. Long-term angiographic and clinical data after microsurgical or endovascular therapies are lacking. OBJECTIVE:To study the clinical and radiographic outcomes in aneurysms in pediatric patients treated with microsurgery. METHODS:Between 1989 and 2005, 48 pa...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000371727.71991.64

    authors: Kakarla UK,Beres EJ,Ponce FA,Chang SW,Deshmukh VR,Bambakidis NC,Zabramski JM,Spetzler RF

    更新日期:2010-08-01 00:00:00

  • Estimating energy expenditure in traumatic brain injury: comparison of indirect calorimetry with predictive formulas.

    abstract::A high degree of variability in energy expenditure has characterized the metabolic response to traumatic brain injury. A goal of parenteral or enteral repletion in this population is the precise estimation of caloric requirement to avoid complications associated with overfeeding and underfeeding. The first aim of this...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199208000-00009

    authors: Sunderland PM,Heilbrun MP

    更新日期:1992-08-01 00:00:00

  • Immunohistochemical detection of intracranial vasa vasorum: a human autopsy study.

    abstract::The existence of intracranial vasa vasorum supplying the larger vessels of the circle of Willis has long been debated. Much of this debate results from contradictory findings of microanatomic studies in a variety of nonprimate species. Recently, however, a growing body of evidence seems to suggest that in certain path...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Connolly ES Jr,Huang J,Goldman JE,Holtzman RN

    更新日期:1996-04-01 00:00:00

  • Moyamoya disease presenting as intracerebral hemorrhage during pregnancy: case report and review of the literature.

    abstract::Intracranial hemorrhage during pregnancy is rare. The authors present a case of moyamoya disease associated with pregnancy. A 32-year-old woman who was at 32 weeks of gestation experienced sudden severe headache followed by loss of consciousness. Computed tomography revealed an intracerebral hematoma in the left tempo...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198701000-00009

    authors: Enomoto H,Goto H

    更新日期:1987-01-01 00:00:00

  • Liliequist's membrane is a fold of the arachnoid mater: study using sheet plastination and scanning electron microscopy.

    abstract:OBJECTIVE:The subarachnoid space consists of a number of distinct subarachnoid cisterns. They are separated from each other by trabecular walls, one of which is Liliequist's membrane. The aim of this study was to investigate the anatomic characteristics of Liliequist's membrane. METHODS:The study used a combined appro...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200010000-00021

    authors: Zhang M,An PC

    更新日期:2000-10-01 00:00:00

  • Isolated paraplegia from a remote stab wound.

    abstract::A stab wound to the right flank of a 24-year-old man produced immediate paralysis of both legs but spared sensation. Recovery was slow but sufficient to allow walking with a cane. Radicular artery interruption, in combination with systemic hypotension, is presumed to have caused selective watershed infarction of the s...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199308000-00014

    authors: Keane JR,Gamal R

    更新日期:1993-08-01 00:00:00

  • Pearls for Interpreting Neurosurgical Systematic Reviews and Meta-Analyses: Lessons From a Collaborative Effort.

    abstract::Systematic reviews and meta-analyses in the neurosurgical literature have surged in popularity over the last decade. It is our concern that, without a renewed effort to critically interpret and appraise these studies as high or low quality, we run the risk of the quality and value of evidence-based medicine in neurosu...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyaa027

    authors: Lu VM,Graffeo CS,Perry A,Link MJ,Meyer FB,Dawood HY,Mekary RA,Smith TR

    更新日期:2020-09-01 00:00:00

  • Quinacrine enhances carmustine therapy of experimental rat glioma.

    abstract:OBJECTIVE:The high rate of mutagenesis in malignant cells has been considered to be a primary factor in the appearance of chemotherapy-resistant cell clones in glioblastomas. Quinacrine binds strongly to deoxyribonucleic acid, preventing mutagenesis. We investigated whether quinacrine could improve carmustine therapy i...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200110000-00033

    authors: Reyes S,Herrera LA,Ostrosky P,Sotelo J

    更新日期:2001-10-01 00:00:00

  • Vietnam, 1968-1969: a place and a year like no other.

    abstract::THE VIETNAM WAR touched a generation of Americans with its human tragedy, sacrifice, and strife. In terms of casualties, it was the fourth most costly war in American history. However, despite a monumental military effort and modern technology, the war was lost as support from the American public and its elected offic...

    journal_title:Neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.1227/01.neu.0000053179.51319.d0

    authors: Kelly PJ

    更新日期:2003-04-01 00:00:00

  • Microvascular decompression to treat hemifacial spasm: long-term results for a consecutive series of 143 patients.

    abstract:OBJECTIVE:The concept of neurovascular decompression for the treatment of hemifacial spasm is now widely accepted. In this study, we report our long-term results for 145 cases treated with this procedure. METHODS:The results of 145 microvascular decompressions to treat hemifacial spasm (performed between 1980 and 1998...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200204000-00005

    authors: Samii M,Günther T,Iaconetta G,Muehling M,Vorkapic P,Samii A

    更新日期:2002-04-01 00:00:00

  • Successful separation of craniopagus parasiticus.

    abstract:OBJECTIVE:Craniopagus parasiticus is an extremely rare condition. The first attempt to separate such twins was performed in the Dominican Republic in 2004. The infant died 7 hours after surgery. The aim of this report is to present a case in which surgical separation was successfully performed on February 18, 2005. In ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000245587.23710.A6

    authors: Lotfy M,Sakr SA,Ayoub BM

    更新日期:2006-11-01 00:00:00

  • Is Admission Lipoprotein-Associated Phospholipase A2 a Novel Predictor of Vasospasm and Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage?

    abstract:BACKGROUND:The relationships between lipoprotein-associated phospholipase A2 (Lp-PLA2) level, vasospasm, and clinical outcome of patients with aneurysmal subarachnoid hemorrhage (aSAH) are still unclear. OBJECTIVE:To identify the associations between admission Lp-PLA2 and vasospasm following subarachnoid hemorrhage an...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyz041

    authors: Ding CY,Cai HP,Ge HL,Yu LH,Lin YX,Kang DZ

    更新日期:2020-01-01 00:00:00

  • Refined and simplified surgical landmarks for the MacCarty keyhole and orbitozygomatic craniotomy.

    abstract:BACKGROUND:Precise placement of the MacCarty keyhole, a burr hole simultaneously exposing the anterior cranial fossa floor and orbit, provides accurate, efficient entry for orbitozygomatic and supraorbital craniotomies. To locate the optimal keyhole site, previous studies have used superficial landmarks that, in our ex...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000369650.69583.9C

    authors: Tubbs RS,Loukas M,Shoja MM,Cohen-Gadol AA

    更新日期:2010-06-01 00:00:00