Abstract:
OBJECTIVE:Immunostaining for p53 commonly is considered a marker of neoplasia. Previous studies of nonneoplastic processes have yielded conflicting results. METHODS:To test the assumption that p53 immunoreactivity indicates neoplasia, we examined 60 formalin-fixed, paraffin-embedded biopsies of nonneoplastic central nervous system lesions, including gliosis (n = 12), infarction (n = 9), demyelinating disease (n = 23), progressive multifocal leukoencephalopathy (n = 11), and herpes simplex virus encephalitis (n = 5). Diffuse astrocytomas (n = 50) of World Health Organization Grades 2 to 4 also were studied, as were six control autopsy brains. The avidin-biotin-peroxidase complex method was used with commercially available monoclonal antisera to both p53 (clone DO7; Dako, Carpinteria, CA) and mdm2 (Dako), a protein known to stabilize p53. Two samples of each nonneoplastic lesion also were subjected to deoxyribonucleic acid isolation, amplification, and sequencing of exons 5 to 8 of TP53. RESULTS:Although it was low level in most instances, p53 immunoreactivity was noted in all but normal control samples. In reactive lesions, staining was largely observed in astrocytes and histiocytes. Scant oligodendroglia also were labeled in demyelinating disease. The progressive multifocal leukoencephalopathy samples revealed exceptionally strong staining in astrocytes and infected oligodendrocytes. Staining also was noted in occasional endothelial cells and neurons, and in rare lymphocytes. Immunoreactivity for mdm2, studied only in nonneoplastic lesions, was moderate to strong in all cases and limited to reactive astrocytes and histiocytes. No TP53 mutations were noted in the nonneoplastic lesions studied. To some extent, all astrocytomas exhibited p53 immunopositivity, particularly high-grade lesions. CONCLUSION:p53 immunoreactivity is not limited to astrocytomas, but it can be observed in lesions that often are mistaken for glioma. No TP53 mutations accompany p53 expression in nonneoplastic lesions, and mdm2 may be responsible for persistence of p53 expression in these processes.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Kurtkaya-Yapicier O,Scheithauer BW,Hebrink D,James CDdoi
10.1097/00006123-200211000-00021keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1246-54; discussion 1254-5issue
5eissn
0148-396Xissn
1524-4040journal_volume
51pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract::Samples of ventricular cerebrospinal fluid, tumor cyst fluid, and subdural fluid were obtained from 30 patients at operation. The protein concentration and the specific gravity of each sample were measured and the corresponding mean absorption numbers were calculated from the numerical printout of the preoperative com...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-197907010-00003
更新日期:1979-07-01 00:00:00
abstract:OBJECTIVE:To save the patency of the internal carotid artery (ICA) during the treatment of carotid cavernous fistulae or cavernous sinus dural arteriovenous malformations, direct surgery of the cavernous sinus after failure of endovascular treatment was attempted in this study. METHODS:A total of 78 patients with caro...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199710000-00006
更新日期:1997-10-01 00:00:00
abstract::Flow diversion is a safe and effective treatment for many types of brain aneurysms. Even so, there remain some aneurysms that persist despite initial treatment. In studies with the longest follow-up (5 yr), at least 5% of aneurysms persist with this treatment modality. As the cumulative experience and clinical indicat...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyz305
更新日期:2020-01-01 00:00:00
abstract::Neurosurgery is experiencing a period of acute change driven by 2 forces: (1) the perception that the healthcare system in the United States is wasteful and that patients are receiving low "value" care, (2) the belief that quality and long-term outcomes can be measured accurately. We believe 3 important shifts will em...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1093/neuros/nyx008
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:An intracranial aneurysm is an important acquired cerebrovascular disease that can cause a catastrophic subarachnoid hemorrhage. Despite modern therapy, most patients die or are left disabled as a direct result of a severe initial hemorrhage. The development of more effective treatment strategies depends on u...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199911000-00024
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:Interhemisperic lipomas are almost always associated with hypogenesis or agenesis of the corpus callosum. These lesions are stable. CLINICAL PRESENTATION:We report a case of an interhemispheric lipoma in a 72-year-old man who had undergone myelolipomatous differentiation. INTERVENTION:Gross total excision o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000317326.09601.51
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:The author presents data to support the continued need for ablative procedures, particularly cordotomy, in the management of cancer-related pain. METHODS:Fifty-one patients with cancer-related body or face pain were treated with computed tomography-guided radiofrequency ablation of the spinothalamic tract or...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1227/01.neu.0000317397.16089.f5
更新日期:2008-03-01 00:00:00
abstract:STANDARDS:Prophylactic treatment of thromboembolism in patients with severe motor deficits due to spinal cord injury is recommended. The use of low-molecular-weight heparins, rotating beds, adjusted dose heparin, or a combination of modalities is recommended as a prophylactic treatment strategy. Low-dose heparin in com...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-200203001-00014
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Silent corticotroph adenomas (SCAs) are clinically nonfunctioning pituitary adenomas (NFPAs) with positive staining for corticotropin (ACTH) by immunohistochemistry. Whether SCAs behave more aggressively than NFPAs without ACTH immunoreactivity (ACTH negative) remains controversial. OBJECTIVE:To compare cha...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e318257c1f0
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Intracranial dural arteriovenous fistulae (DAVFs) can present as disabling intracranial hemorrhage. The aim of this study was to investigate the independent effects of specific demographic and clinical variables on hemorrhagic presentation in patients with DAVFs. METHODS:All patients with DAVFs evaluated at ...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1227/01.neu.0000317311.69697.fc
更新日期:2008-03-01 00:00:00
abstract::The scope and purpose of this work is 2-fold: to synthesize the available evidence and to translate it into recommendations. This document provides recommendations only when there is evidence to support them. As such, they do not constitute a complete protocol for clinical use. Our intention is that these recommendati...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000001432
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Resection of cerebellopontine angle (CPA) meningiomas may result in significant neurological morbidity. Radiosurgery offers a minimally invasive alternative to surgery. OBJECTIVE:To evaluate, in a multicenter cohort study, the outcomes of patients harboring CPA meningiomas who underwent Gamma Knife radiosur...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1227/NEU.0000000000000480
更新日期:2014-10-01 00:00:00
abstract::A patient with unusual angiographic changes of a dissecting aneurysm of the basilar artery is presented. Initial angiography and magnetic resonance imaging revealed a typical dissecting aneurysm. However, a follow-up study demonstrated a saccular aneurysmal dilatation of the proximal part of the dissection. The import...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199402000-00022
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:The biggest downside of cerebral aneurysm coiling is the high rates of recurrence and retreatments. With the increasing number of aneurysm recurrences after failed coiling procedures, the best retreatment strategy remains unknown. OBJECTIVE:To assess the efficacy and safety of the Pipeline Embolization Devi...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000901
更新日期:2015-11-01 00:00:00
abstract::THE IDEAL GRAFT material to promote spinal fusion should possess osteoconductive, osteoinductive, and osteogenic properties. Although autogenous bone graft has all three qualities and is the standard for comparison, research has focused on finding alternatives that have similar efficacy but not the morbidities associa...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/01.NEU.0000324990.04818.13
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:As brain temperature is reported to be extensively higher than core body temperature in traumatic brain injury (TBI) patients, posttraumatic hyperthermia is of particular relevance in the injured brain. OBJECTIVE:To study the influence of prophylactic normothermia on brain temperature and the temperature gr...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1227/NEU.0b013e318208f5fb
更新日期:2011-04-01 00:00:00
abstract::Negative findings on four-vessel angiography after a subarachnoid hemorrhage are seen in 5 to 30% of patients. A previously silent lesion in the spinal canal may be responsible for the ictus in a small percentage of this group. The etiological factors include tumors and arteriovenous malformations; however, investigat...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199010000-00022
更新日期:1990-10-01 00:00:00
abstract::COSTANZO VAROLIO (CONSTANTIUS Varolius) (1543-1575) was born in Bologna and died in Rome. This professor of anatomy and papal physician was the first to examine the brain from its base up, in contrast with previous dissections of this organ performed from the top down. Varolio was the first to describe many structures...
journal_title:Neurosurgery
pub_type: 传,历史文章,杂志文章
doi:10.1227/01.neu.0000317323.63859.2a
更新日期:2008-03-01 00:00:00
abstract::A new head-positioning system has been developed to hold the head firmly during the performance of a computed tomograhic scan and to position the head reproducibly during repeat scans. This can be used to maintain the head in position during long scanning sessions, to relate a lesion to landmarks on scout views, to fo...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198008000-00006
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:Chordomas are rare but challenging neoplasms involving the skull base. A preoperative grading system will be useful to identify both areas for treatment and risk factors, and correlate to the degree of resection, complications, and recurrence. OBJECTIVE:To propose a new grading system for cranial chordomas ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyx423
更新日期:2018-09-01 00:00:00
abstract::The author presents the results of primary cystoperitoneal shunting in 12 infants and children with developmental cysts in various intracranial locations. Preoperative studies were done in each child to rule out a brain tumor as the cause of the cyst and to determine whether communication existed between the cyst and ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198106000-00002
更新日期:1981-06-01 00:00:00
abstract:BACKGROUND:Pernkopf's atlas of Anatomy contains anatomical plates with detailed images of the peripheral nerves. Its use is controversial due to the author's association with the "Third Reich" and the potential depiction of victims of the Holocaust. The ethical implications of using this atlas for informing surgical pl...
journal_title:Neurosurgery
pub_type: 历史文章,杂志文章
doi:10.1093/neuros/nyy159
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Classification of middle cerebral artery (MCA) aneurysms is sometimes difficult because the identification of the main MCA bifurcation, the key for accurate classification of MCA aneurysms, is inconsistent and somewhat subjective. OBJECTIVE:To use the meeting point of the M1 and M2 trunks as an objective, g...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000429842.61213.d5
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Skull base osteosarcomas are aggressive neoplasms characterized by bony invasion and extracompartmental/extra-osseous soft tissue extension that pose obstacles to achieving complete resection. Management is further complicated by the paucity of data regarding the efficacy of surgery within the treatment para...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyz360
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Acquired immunity has been demonstrated in Fischer rats bearing syngeneic 9L tumors after herpes simplex virus (HSV) thymidine kinase (TK) gene transfection and ganciclovir treatment. The nature of this immunity in rats and its relevance to the HSV TK/ganciclovir protocol for human subjects remain to be deter...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200109000-00028
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of early optic canal unroofing on visual function in patients with meningiomas of the tuberculum sellae and planum sphenoidale. METHODS:We retrospectively reviewed the clinical records of 20 consecutive patients with tuberculum sellae meningiomas and two patie...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000318169.75095.cb
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:Patients with partial or complete bilateral vertebral artery occlusion often present with signs and symptoms of transient ischemic attacks or infarction. Advances in phase contrast magnetic resonance imaging have led to noninvasive assessment of volumetric blood flow rates and direction that help in the worku...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000339351.65061.D6
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Epithelial cysts of the central nervous system are unusual entities, with the majority reported to occur in the spinal canal. More unusual is the intracranial presentation, which shows a predilection for midline localization in the posterior fossa, brainstem, and suprasellar regions. This repor...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:This study was designed to more precisely characterize the changes in exposure achieved by modifying the standard transoral approach by sequential mandibulotomy and mandibuloglossotomy with or without palatotomy. METHODS:A series of cadaveric dissections was performed and the operative distance and angle of ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000317386.99055.3f
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:An approach to transnasal transsphenoidal debulking of pituitary tumors using endoscopic guidance is presented. METHODS:Technical details of this approach using an endoscope inserted through one nostril and operating instruments inserted through a submucosal tunnel created via the other nostril are discussed...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199607000-00046
更新日期:1996-07-01 00:00:00