Abstract:
OBJECTIVE:An intracranial aneurysm is an important acquired cerebrovascular disease that can cause a catastrophic subarachnoid hemorrhage. Despite modern therapy, most patients die or are left disabled as a direct result of a severe initial hemorrhage. The development of more effective treatment strategies depends on understanding the fundamental biology of cerebral aneurysms. The purpose of the present study is to determine whether inflammation or immunological reaction occurs in cerebral aneurysms. METHODS:Aneurysm tissue was collected at the time of microsurgical repair from 23 unruptured and 2 ruptured aneurysms (25 patients) and compared with 11 control basilar arteries harvested at autopsy. Immunohistochemistry was used to localize complement (C3c, C9), immunoglobulins (IgG, IgM), vascular cell adhesion molecule-1, macrophages and monocytes (CD68), T lymphocytes (CD3), and B lymphocytes (CD20). RESULTS:Complement (C3c, P < 0.0001; C9, P = 0.0017), immunoglobulin (IgG, P = 0.0013; IgM, P = 0.031), vascular cell adhesion molecule-1 (P = 0.0022), macrophages (CD68, P = 0.004), and T lymphocytes (CD3, P = 0.0004) were all frequently present in the wall of aneurysm tissue but were rarely identified in control basilar arteries. A few B lymphocytes (CD20, P = 0.41) were found in aneurysm tissue, but none were found in the basilar arteries. CONCLUSION:Extensive inflammatory and immunological reactions are common in unruptured intracranial aneurysms and may be related to aneurysm formation and rupture.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Chyatte D,Bruno G,Desai S,Todor DRdoi
10.1097/00006123-199911000-00024keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
1137-46; discussion 1146-7issue
5eissn
0148-396Xissn
1524-4040journal_volume
45pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract:OBJECTIVE:Adult gliomas have indistinct borders. As the ratio of neoplastic cells to normal cells becomes lower, the ability to detect these cells diminishes. We describe a device designed to augment intraoperative identification of both solid tumor and infiltrating tumor margins. METHODS:A novel, intraoperative, opti...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1227/01.neu.000176855.39826.2d
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:The benefits of radiation therapy are generally denied to infants with malignant brain tumors because of the risk of devastating cognitive decline. Efforts to limit this morbidity with radiosurgical techniques have not been feasible for infants because of the dual requirements of rigid head fixation and high ...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1227/01.neu.0000137332.03970.57
更新日期:2004-10-01 00:00:00
abstract::We present two cases of false aneurysm after carotid endarterectomy with primary arteriotomy closure. In both cases, infection appeared to be the precipitating cause. Both lesions were repaired with a saphenous vein patch graft, but infection in one patient persisted, and recurrence of a false aneurysm required ligati...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198609000-00014
更新日期:1986-09-01 00:00:00
abstract:OBJECTIVE:To determine the clinical presentation, imaging characteristics, microscopic and ultrastructural characteristics, and treatment outcomes of patients with clinically silent pituitary corticotroph adenomas. METHODS:All silent corticotroph adenomas diagnosed at the Mayo Clinic during the years 1975 through 1997...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200009000-00039
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:This study was undertaken to assess the reliability of the aspect ratio (AR) (i.e., aneurysm depth to aneurysm neck) in predicting aneurysm rupture. It has been shown that the AR is a key factor in predicting intraaneurysmal blood flow and aneurysm rupture. METHODS:Seventy-five patients with subarachnoid hem...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000124482.03676.8b
更新日期:2004-06-01 00:00:00
abstract::Because conventional stereotactic angiography provides only two-dimensional information for dose planning, we studied the accuracy and usefulness of stereotactic magnetic resonance angiography (sMRA) for arteriovenous malformation (AVM) radiosurgery in 28 consecutive patients. We hypothesized that the multidimensional...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199410000-00002
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Classification of middle cerebral artery (MCA) aneurysms is sometimes difficult because the identification of the main MCA bifurcation, the key for accurate classification of MCA aneurysms, is inconsistent and somewhat subjective. OBJECTIVE:To use the meeting point of the M1 and M2 trunks as an objective, g...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000429842.61213.d5
更新日期:2013-07-01 00:00:00
abstract::Operations on the 4th ventricle offer the potential for injury of the brain stem, cerebellum, cranial nerves, and major cerebellar arteries and veins. Twenty-five cadaver brains were examined using 3x to 25x magnification to define the relationship of these vital structures to the 4th ventricle. The 4th ventricle has ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198211000-00008
更新日期:1982-11-01 00:00:00
abstract::Coronary thrombolysis with streptokinase or tissue plasminogen activator is useful for the treatment of acute myocardial infarction in selected patients. This treatment is associated with local hemorrhagic complications and age-related cerebral hemorrhage. Coronary thrombolysis is contraindicated in patients with tran...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199209000-00025
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:Many patients with symptomatic Chiari I malformations experience symptom recurrence after surgical decompression. Identification of predictors of outcome is needed to better select patients most likely to benefit from surgical intervention. We examined whether or not cerebrospinal fluid (CSF) flow dynamics as...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000219841.73999.B3
更新日期:2006-07-01 00:00:00
abstract::An animal model was developed for studying the pharmacokinetics of antibiotics administered intraventricularly in hydrocephalus. Obstructive hydrocephalus was consistently produced in craniectomized adult rats by injecting kaolin into the cisterna magna. After induction of hydrocephalus, vancomycin was injected into t...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198606000-00008
更新日期:1986-06-01 00:00:00
abstract::The use OF chemotherapy to treat patients with brain metastases has been viewed historically with skepticism. To date, a survival benefit has not been demonstrated with the use of systemic chemotherapy in patients with brain metastases. However, the introduction of novel agents and delivery techniques warrants a reexa...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/01.neu.0000182740.39014.9a
更新日期:2005-11-01 00:00:00
abstract::Visual field abnormalities were studied in a retrospective analysis of 199 patients with epidural hematomas. One hundred three patients had been alert enough at the time of hospital admission to have had their visual fields examined, but in only 27 patients were visual fields documented in the charts. Six of the 27 pa...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198208000-00007
更新日期:1982-08-01 00:00:00
abstract::A retrospective study of 119 operative procedures for intracranial aneurysm was performed to compare the clinical result with microsurgical technique vs. that with standard instruments and without magnification; the operative technique was the major variable. The study demonstrated more normal patients, less intraoper...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198204000-00001
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND:The optimal management of unruptured brain arteriovenous malformations (AVMs) is controversial after the ARUBA trial. OBJECTIVE:To confirm or repudiate the ARUBA conclusion that "medical management only is superior to medical management with interventional therapy for unruptured brain arteriovenous malforma...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyy391
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Transoral odontoidectomy and resection of the anterior C1 arch destabilize the atlantoaxial joint and risk its stability. OBJECTIVE:To preserve stability in such cases we devised and evaluated a proof-of-concept study. The arch and dens were dissected and decompression was performed on cadavers. The dens wa...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31820934a9
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Neoplasms of the paranasal sinuses account for 0.2 to 0.8% of all cancers and for 2 to 3% of head and neck cancers. Primary involvement of the sphenoidal sinus has been reported to occur in only 1 to 2% of all paranasal sinus tumors. Tumors at this site commonly present with cranial neuropathies and require m...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200005000-00012
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:Animal models and clinical studies suggest that intraventricular thrombolysis improves clot resolution and clinical outcomes among patients with intraventricular hemorrhage. However, this intervention may increase the rates of rebleeding and infection. To assess the safety and efficacy of intraventricular thr...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1227/01.neu.0000108422.10842.60
更新日期:2004-03-01 00:00:00
abstract::We performed a retrospective study of 107 consecutive patients with syndromic forms of craniosynostosis (craniofacial dysostosis) seen by the craniofacial team at the Hospital for Sick Children between 1986 and 1992. There were 51 patients with Crouzon's syndrome, 33 with Apert's syndrome, 8 with Pfeiffer syndrome, 11...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199504000-00010
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:Intracranial empyemas are the most common form of intracranial suppuration seen in our unit and, despite modern antibiotic therapy and advanced neurosurgical and imaging facilities, these pus collections remain a formidable challenge, often resulting in significant morbidity and death. We present an analysis ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199903000-00055
更新日期:1999-03-01 00:00:00
abstract::Intraoperative monitoring with electroencephalography and the use of brain protection with steroids, phenytoin, mannitol, and pentobarbital or etomidate were evaluated in 15 patients undergoing operation for an aneurysm of the upper basilar artery. One patient harbored a basilar trunk aneurysm, 1 an aneurysm of the pr...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-198912000-00008
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:To demonstrate that malignant glioneuronal tumors comprise a large spectrum of neoplasms, without mature ganglion-like cells, that may histologically resemble any malignant glioma (World Health Organization Grade III or IV) but have a distinct biological behavior. METHODS:This series includes all tumors diag...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1227/01.neu.0000143033.36582.40
更新日期:2004-12-01 00:00:00
abstract::Local steroid injections for symptomatic relief of carpal tunnel syndrome have become common in the evaluation and treatment of this disorder; yet reports of median nerve injection injury from this practice are rare. We present a case of nerve injury from a steroid injection in a 24-year-old man with carpal tunnel syn...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199003000-00021
更新日期:1990-03-01 00:00:00
abstract::To improve the localization of stereotactic targets, somatosensory evoked potentials (SEPs) were recorded from the thalamus and subthalamic area using a specially designed semimicroelectrode in 61 patients and a conventional "macroelectrode" in 17 patients. By means of the semimicroelectrode, median nerve stimulation ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199102000-00008
更新日期:1991-02-01 00:00:00
abstract::Intracranial epidermoid and dermoid tumors are unusual benign lesions that are potentially curable. Subtotal removal carries a high incidence of recurrence, plus the rare possibility of carcinomatous degeneration of the remnants. Aseptic meningitis from spillage of cyst contents into the subarachnoid space is frequent...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/00006123-198904000-00014
更新日期:1989-04-01 00:00:00
abstract::The authors review their experience with a dorsolateral approach to the anterior rim of the foramen magnum and adjacent region. The operative technique includes exposure of the vertebral artery at C1, partial resection of the occipital condyle and lateral atlantal mass, and extradural drilling of the jugular tubercle....
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199112000-00002
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:Obtaining a watertight reconstruction with a fat graft with wide sellar exposures can be challenging, including the risk of reinstating mass effect with the fat graft. The alternative, a vascularized pedicle nasoseptal flap, may require several days to heal and still has a > 5% cerebrospinal fluid (CSF) leak...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e318241af25
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:The management of patients with a Chiari I malformation who present with headaches alone remains unclear. We studied the cerebrospinal fluid (CSF) flow dynamics of Chiari I malformation patients presenting with headaches alone so as to identify headache types that are associated with CSF flow obstruction vers...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000156203.20659.14
更新日期:2005-04-01 00:00:00
abstract::Selected commercially designated temporary clips (Acland, Biemer, Kleinert-Kutz, Variangle, and Yasargil) were applied for 1 hour to rat common carotid arteries. Scanning electron and light microscopic studies revealed varying degrees of endothelial damage. The authors believe that further improvements are needed in t...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-197910000-00009
更新日期:1979-10-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:We describe a patient with a cavernous malformation within the trigeminal nerve at the nerve root entry zone who presented with trigeminal neuralgia. CLINICAL PRESENTATION:A 52-year-old woman sought treatment after experiencing dizziness and lancinating left facial pain for almost a year. Neur...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00