Primary spinal intramedullary malignant melanoma: case report.

Abstract:

:A rare case of primary spinal intramedullary malignant melanoma at the T6 level in a 31-year-old man is presented. The tumor was partially removed, and neuroaxis irradiation up to 50 Gy was then administered. Subsequently, systemic interferon beta (specific activity, 2.0 X 10(8) IU/mg protein) therapy (total dose, 2.2 X 10(7) units) was begun. At the completion of these therapies, immunohistochemical analysis with monoclonal antibodies against melanoma-associated antigens confirmed the presence of melanoma cells in the cerebrospinal fluid (CSF). Chemotherapy with intrathecal administration of dacarbazine (dimethyltriazenoimidazole carboxamide, DTIC) was then initiated, to avoid the dissemination of tumor cells by the CSF. Periodic cytological examination of CSF for melanoma cells revealed a marked reduction in the number of tumor cells. Pharmacokinetic study showed that the disappearance of DTIC from the CSF was biphasic, with an initial half-life of 30 minutes and a terminal half-life of 5 hours. Follow-up examination by MRI 1 year after the operation did not disclose any significant increase in size of the residual tumor. Neither recurrence nor metastasis was observed. The pertinent literature on spinal cord melanoma is reviewed, and the usefulness of MRI and intrathecal chemotherapy with DTIC is discussed.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Yamasaki T,Kikuchi H,Yamashita J,Asato R,Fujita M

doi

10.1097/00006123-198907000-00023

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

117-21

issue

1

eissn

0148-396X

issn

1524-4040

journal_volume

25

pub_type

杂志文章
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    authors: Antoniadis G,Richter HP,Schachenmayr W

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  • Intraventricular cavernous hemangioma: report of three cases and review of the literature.

    abstract::The clinical and radiographic presentations of 3 patients with intraventricular cavernous hemangioma are described. The accumulated total of 19 cases from the literature are compared to determine whether there is a common clinical and radiographic presentation for this benign intraventricular lesion. The differential ...

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    authors: Chadduck WM,Binet EF,Farrell FW Jr,Araoz CA,Reding DL

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  • Propionibacterium acnes causes postoperative brain abscesses unassociated with foreign bodies: case reports.

    abstract::Propionibacterium acnes was isolated in pure culture from brain abscesses that occurred in two patients after intracranial surgery. Although such infections are usually associated with cerebrospinal fluid shunts and other foreign bodies, these cases clearly demonstrate the pathogenicity of this anaerobic diphtheroid i...

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    doi:10.1097/00006123-198907000-00026

    authors: Berenson CS,Bia FJ

    更新日期:1989-07-01 00:00:00

  • International subarachnoid aneurysm trial 2009: endovascular coiling of ruptured intracranial aneurysms has no significant advantage over neurosurgical clipping.

    abstract::In the May 2009 issue of The Lancet Neurology, the 5-year follow-up results of the International Subarachnoid Aneurysm Trial (ISAT) were published. The authors concluded that, although the significant difference between coiling and neurosurgical clipping of ruptured intracranial aneurysms in terms of death and severe ...

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    authors: Bakker NA,Metzemaekers JD,Groen RJ,Mooij JJ,Van Dijk JM

    更新日期:2010-05-01 00:00:00

  • Effect of Prior Embolization on Cerebral Arteriovenous Malformation Radiosurgery Outcomes: A Case-Control Study.

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    authors: Oermann EK,Ding D,Yen CP,Starke RM,Bederson JB,Kondziolka D,Sheehan JP

    更新日期:2015-09-01 00:00:00

  • External ventricular drain insertion accuracy: is there a need for change in practice?

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    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000356973.39913.0B

    authors: Toma AK,Camp S,Watkins LD,Grieve J,Kitchen ND

    更新日期:2009-12-01 00:00:00

  • Giant cell granuloma of the orbit with intracranial extension.

    abstract::An 8-year-old boy presented with acute proptosis of the right eye. Examination revealed 8 mm of exophthalmos, limitation of upward gaze, optic disc swelling, and normal visual acuity, but an inferonasal quadrantic visual field defect. Orbital ultrasound and computed tomographic scanning demonstrated a superotemporal t...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Sebag J,Chapman P,Truman J,Riemersma RR

    更新日期:1985-01-01 00:00:00

  • Intraventricular thrombolysis speeds blood clot resolution: results of a pilot, prospective, randomized, double-blind, controlled trial.

    abstract:OBJECTIVE:Animal models and clinical studies suggest that intraventricular thrombolysis improves clot resolution and clinical outcomes among patients with intraventricular hemorrhage. However, this intervention may increase the rates of rebleeding and infection. To assess the safety and efficacy of intraventricular thr...

    journal_title:Neurosurgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1227/01.neu.0000108422.10842.60

    authors: Naff NJ,Hanley DF,Keyl PM,Tuhrim S,Kraut M,Bederson J,Bullock R,Mayer SA,Schmutzhard E

    更新日期:2004-03-01 00:00:00

  • Intracranial hemorrhage and spinal cord injury from a fractured C1-C2 sublaminar cable: case report.

    abstract:OBJECTIVE:This is a unique case report of a fractured atlantoaxial interspinous multistranded cable leading to intracranial hemorrhage and spinal cord injury. CLINICAL PRESENTATION:A 61-year-old woman, with a history of rheumatoid arthritis and C1-C2 interspinous wiring with allograft for atlantoaxial instability, pre...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000369198.70959.E1

    authors: Kakarla UK,Valdivia JV,Sonntag VK,Bambakidis NC

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  • Anterior choroidal artery syndrome after surgery for internal carotid artery aneurysms.

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    doi:10.1227/00006123-199207000-00021

    authors: Suzuki H,Fujita K,Ehara K,Tamaki N

    更新日期:1992-07-01 00:00:00

  • Challenges in contemporary academic neurosurgery.

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  • Pyogenic abscess of the medulla oblongata.

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    pub_type: 杂志文章

    doi:10.1227/00006123-198603000-00024

    authors: Dake MD,McMurdo SK,Rosenblum ML,Brant-Zawadzki M

    更新日期:1986-03-01 00:00:00

  • Modulation of the cerebello-thalamo-cortical network in thalamic deep brain stimulation for tremor: a diffusion tensor imaging study.

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    doi:10.1227/NEU.0000000000000540

    authors: Coenen VA,Allert N,Paus S,Kronenbürger M,Urbach H,Mädler B

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    pub_type: 杂志文章

    doi:10.1097/00006123-199705000-00009

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  • Arteriovenous malformation draining vein physiology and determinants of transnidal pressure gradients. The Columbia University AVM Study Project.

    abstract::Arteriovenous malformation (AVM) draining vein pressure (DVP) may have an influence on both the natural history of the disease and treatment outcome. The purposes of this study were to assess the relationship between DVP and other clinical and physiological variables and to characterize the transmission of arterial pr...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199409000-00005

    authors: Young WL,Kader A,Pile-Spellman J,Ornstein E,Stein BM

    更新日期:1994-09-01 00:00:00

  • Neurosurgical considerations after bull goring during festivities in Spain and Latin America.

    abstract::Bullfighting is a highly popular activity during festivities in Spain and Latin America. A scientific society for bullfight injuries, Congreso Internacional de Cirugía Taurina, was founded on November 24, 1974, in recognition of the distinctive pattern of injury that results from bull goring, and a subspecialty of gen...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/NEU.0b013e3182191fb1

    authors: Spiotta AM,Matoses SM

    更新日期:2011-08-01 00:00:00

  • Immunomodulation of glioma cells after gene therapy: induction of major histocompatibility complex class I but not class II antigen in vitro.

    abstract:OBJECTIVE:Acquired immunity has been demonstrated in Fischer rats bearing syngeneic 9L tumors after herpes simplex virus (HSV) thymidine kinase (TK) gene transfection and ganciclovir treatment. The nature of this immunity in rats and its relevance to the HSV TK/ganciclovir protocol for human subjects remain to be deter...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200109000-00028

    authors: Parsa AT,Chi JH,Hurley PT,Jeyapalan SA,Bruce JN

    更新日期:2001-09-01 00:00:00

  • Current management of middle cerebral artery aneurysms: surgical results with a "clip first" policy.

    abstract:BACKGROUND:One response to randomized trials like the International Subarachnoid Aneurysm Trial has been to adopt a "coil first" policy, whereby all aneurysms be considered for coiling, reserving surgery for unfavorable aneurysms or failed attempts. Surgical results with middle cerebral artery (MCA) aneurysms have been...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e3182804aa2

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    更新日期:2013-03-01 00:00:00

  • Evaluation of hydrocephalic periventricular radiolucency by dynamic computed tomography and xenon-computed tomography.

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    journal_title:Neurosurgery

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  • Association of surgically acquired motor and language deficits on overall survival after resection of glioblastoma multiforme.

    abstract:OBJECTIVE:Balancing the benefits of extensive tumor resection with the consequence of potential postoperative deficits remains a challenge in malignant astrocytoma surgery. Although studies have suggested that increasing extent of resection may benefit survival, the effect of new postoperative deficits on survival rema...

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    doi:10.1227/01.NEU.0000349763.42238.E9

    authors: McGirt MJ,Mukherjee D,Chaichana KL,Than KD,Weingart JD,Quinones-Hinojosa A

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  • Surgical approaches to the cavernous sinus: a microsurgical study.

    abstract::The surgical approaches to the cavernous sinus were examined in 50 adult cadaveric cavernous sinuses using magnification of X3 to X40. The following approaches were examined: 1) the superior intradural approach directed through a frontotemporal craniotomy and the roof of the cavernous sinus; 2) the superior intradural...

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    pub_type: 杂志文章

    doi:10.1097/00006123-199006000-00001

    authors: Inoue T,Rhoton AL Jr,Theele D,Barry ME

    更新日期:1990-06-01 00:00:00

  • Traumatic intraventricular hemorrhage treated with intraventricular recombinant-tissue plasminogen activator: technical case report.

    abstract:OBJECTIVE AND IMPORTANCE:Traumatic intraventricular hemorrhage (IVH) can result in association with acute obstructive hydrocephalus, repetitive malfunction of external ventricular drains (EVDs), and uncontrollable increased intracranial pressure. We report a case showing the safe and effective use of intraventricular r...

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    pub_type: 杂志文章

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  • Petriellidium boydii pachymeningitis treated with miconazole and ketoconazole.

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    doi:10.1227/00006123-198402000-00019

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    更新日期:1984-02-01 00:00:00

  • Contralateral and ipsilateral microsurgical approaches to carotid-ophthalmic aneurysms.

    abstract:OBJECTIVE:The vicinity of carotid-ophthalmic aneurysms to the roof of the cavernous sinus, to the anterior clinoid process, and to the optic nerve or the optic chiasm requires well-defined surgical techniques. Although microsurgical techniques with ipsilateral direct approaches to these aneurysms have been described in...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199708000-00001

    authors: Fries G,Perneczky A,van Lindert E,Bahadori-Mortasawi F

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  • Patient Satisfaction and Short-Term Outcome in Elective Cranial Neurosurgery.

    abstract:BACKGROUND:Patient-reported experience is often used as a measure for quality of care, but no reports on patient satisfaction after cranial neurosurgery exist. OBJECTIVE:To study the association of overall patient satisfaction and surgical outcome and to evaluate the applicability of overall patient satisfaction as a ...

    journal_title:Neurosurgery

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    doi:10.1227/NEU.0000000000000931

    authors: Reponen E,Tuominen H,Hernesniemi J,Korja M

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  • Surgical treatment of a large fusiform distal anterior cerebral artery aneurysm with In Situ end-to-side A3-A3 bypass graft and aneurysm trapping: case report and review of the literature.

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    pub_type: 杂志文章,评审

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  • Of Bubbles and Layers: Which Cerebral Cavernous Malformations are Most Difficult to Dissect From Surrounding Eloquent Brain Tissue?

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