Preliminary report: intracranial cholinergic drug infusion in patients with Alzheimer's disease.

Abstract:

:After toxicity studies in dogs, a preliminary feasibility trial of the continuous intracranial infusion of a muscarinic agonist was begun in four patients with biopsy-documented Alzheimer's disease. During the last 8 months, a totally implantable infusion system has been used to deliver bethanechol chloride into the cerebrospinal fluid of these patients at doses of 0.05 to 0.7 mg/day. Complications have been few and resolved spontaneously or were easily reversible. The subjective response to this treatment has been encouraging, with reports of improved cognitive and social function during drug infusion and a return to base line function with single-blind saline placebo infusions. Obviously, further evaluation will be necessary to demonstrate the efficacy of this treatment, and a double-blind placebo-controlled crossover trial is now being done. However, we think the preliminary results are encouraging and warrant the consideration of this approach as a potential treatment in patients with Alzheimer's disease.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Harbaugh RE,Roberts DW,Coombs DW,Saunders RL,Reeder TM

doi

10.1227/00006123-198410000-00007

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

514-8

issue

4

eissn

0148-396X

issn

1524-4040

journal_volume

15

pub_type

临床试验,杂志文章
  • Characteristics of incidental pineal cysts on magnetic resonance imaging.

    abstract::Three patients with different neurological complaints were studied by magnetic resonance imaging. Coincidentally, all studies showed cystic changes within the pineal bodies. These cysts appeared hypointense on T1-weighted, spin-echo pulse sequences and hyperintense on T2-weighted images. Spin-density sequences display...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-198910000-00020

    authors: Sandhu JS,McLaughlin JR,Gomez CR

    更新日期:1989-10-01 00:00:00

  • Trigeminal Nerve Compression Without Trigeminal Neuralgia: Intraoperative vs Imaging Evidence.

    abstract:BACKGROUND:While high-resolution imaging is increasingly used in guiding decisions about surgical interventions for the treatment of trigeminal neuralgia, direct assessment of the extent of vascular contact of the trigeminal nerve is still considered the gold standard for the determination of whether nerve decompressio...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyx636

    authors: Jani RH,Hughes MA,Gold MS,Branstetter BF,Ligus ZE,Sekula RF Jr

    更新日期:2019-01-01 00:00:00

  • Neonatal ventriculosubgaleal shunts.

    abstract:OBJECTIVE:We report on 32 neonates treated with ventriculosubgaleal (VSG) shunts to determine VSG shunt survival and associated complications. METHODS:Between 1993 and 1997, 37 VSG shunts were placed in 32 neonates when the cerebrospinal fluid (CSF) or the abdomen was considered unsuitable for ventriculoperitoneal shu...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200007000-00018

    authors: Fulmer BB,Grabb PA,Oakes WJ,Mapstone TB

    更新日期:2000-07-01 00:00:00

  • Should Levetiracetam or Phenytoin Be Used for Posttraumatic Seizure Prophylaxis? A Systematic Review of the Literature and Meta-analysis.

    abstract:BACKGROUND:Posttraumatic seizure (PTS) is a significant complication of traumatic brain injury (TBI). OBJECTIVE:To perform a systematic review and meta-analysis to compare levetiracetam with phenytoin for seizure prophylaxis in patients diagnosed with severe TBI. METHODS:An inclusive search of several electronic data...

    journal_title:Neurosurgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1227/NEU.0000000000001445

    authors: Khan NR,VanLandingham MA,Fierst TM,Hymel C,Hoes K,Evans LT,Mayer R,Barker F,Klimo P Jr

    更新日期:2016-12-01 00:00:00

  • Local electronic storage of radiological studies for radiosurgery.

    abstract:OBJECTIVE:Although radiosurgical practice mandates meticulous radiological follow-up, even the most efficient radiology department can be overwhelmed by the large number of radiosurgical patients who have undergone diagnostic studies for many years at many different institutions to follow many separate lesions. Althoug...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/01.neu.0000065175.87967.8d

    authors: Giller CA,Clamp SJ

    更新日期:2003-06-01 00:00:00

  • Contralateral cerebellar hemorrhagic infarction after pterional craniotomy: report of five cases and review of the literature.

    abstract:OBJECTIVE AND IMPORTANCE:Five cases of cerebellar hemorrhagic infarction complicating pterional craniotomy are presented. Recognition of this rare complication may be delayed, with catastrophic consequences, because clinicians are unaware of the possibility. We suggest that the mechanism of this complication is disloca...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1097/00006123-199610000-00040

    authors: Papanastassiou V,Kerr R,Adams C

    更新日期:1996-10-01 00:00:00

  • Endovascular therapy of very small aneurysms of the anterior communicating artery: five-fold increased incidence of rupture.

    abstract:BACKGROUND:Intraprocedural rupture is a dangerous complication of endovascular treatment. Small ruptured anterior communicating artery (ACoA) aneurysms and microaneurysms present a challenge for both surgical and endovascular therapies to achieve obliteration. An understanding of the complication rates of treating rupt...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1227/NEU.0b013e3182077373

    authors: Schuette AJ,Hui FK,Spiotta AM,Obuchowski NA,Gupta R,Moskowitz SI,Tong FC,Dion JE,Cawley CM

    更新日期:2011-03-01 00:00:00

  • A percutaneous epidural screw electrode for intracranial electroencephalogram recordings.

    abstract::A new epidural electrode for monitoring brain electrical activity is described. The electrode is a tapered screw that is easily inserted percutaneously and removed without general anesthesia. The epidural screw has been used without complications for ictal and interictal electroencephalogram recordings in four patient...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199308000-00026

    authors: Ross DA,Henry TR,Dickinson LD

    更新日期:1993-08-01 00:00:00

  • Embolization of spinal dural arteriovenous fistulae: results and follow-up.

    abstract:OBJECTIVE:To evaluate the efficacy of embolization for spinal dural arteriovenous fistulae (SDAVF). METHODS:We reviewed 49 cases of SDAVF treated by embolization. An acrylic material was used in all except two cases. Variable stiffness microcatheters were used in 38 cases. RESULTS:"Adequate" initial treatment was per...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1097/00006123-199704000-00004

    authors: Niimi Y,Berenstein A,Setton A,Neophytides A

    更新日期:1997-04-01 00:00:00

  • Thromboxane synthase inhibitors induce apoptosis in migration-arrested glioma cells.

    abstract:OBJECTIVE:Because of the wide dissemination of malignant glioma cells by the time that malignant glioma is diagnosed, anti-invasive strategies that are designed to limit their further spread may be of little value unless mechanisms of the invasive cascade can be used to render invasive cells susceptible to cytoreductiv...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200202000-00021

    authors: Yoshizato K,Zapf S,Westphal M,Berens ME,Giese A

    更新日期:2002-02-01 00:00:00

  • Clinical studies of de novo aneurysms.

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    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199304000-00004

    authors: Sakaki T,Tominaga M,Miyamoto K,Tsunoda S,Hiasa Y

    更新日期:1993-04-01 00:00:00

  • The utility and feasibility of business training for neurosurgeons.

    abstract:OBJECTIVE:Socioeconomic changes have imposed many administrative demands on neurosurgeons, including managing facilities such as the intensive care unit without absolute authority and maintaining referrals, marketing in an increasingly competitive environment, effecting change within stubborn hospital systems, negotiat...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000318180.80040.d0

    authors: Giller CA

    更新日期:2008-04-01 00:00:00

  • Hyperbaric oxygen in the treatment of a radiosurgical complication: technical case report.

    abstract:OBJECTIVE:Hyperbaric oxygenation is a rarely used method of treatment for steroid-refractory radiation-induced edema after stereotactic radiosurgery. We present its successful implementation for a radiosurgical complication after the treatment of a deep, large arteriovenous malformation. We also review the literature o...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000255343.41206.6F

    authors: Lynn M,Friedman WA

    更新日期:2007-03-01 00:00:00

  • Fate of clots in patients with subarachnoid hemorrhage after different surgical treatment modality: a comparison between surgical clipping and Guglielmi detachable coil embolization.

    abstract:BACKGROUND:Subarachnoid clot is important in the development of delayed vasospasm after subarachnoid hemorrhage (SAH). OBJECTIVE:To compare the clearance of subarachnoid clot and the incidence of symptomatic vasospasm in surgical clipping and embolization with Guglielmi detachable coils for aneurysmal SAH. METHODS:Th...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e318208f1ba

    authors: Shirao S,Yoneda H,Ishihara H,Harada K,Ueda K,Sano Y,Kudomi S,Hayashi Y,Shigeeda T,Nakano K,Nomura S,Fujii M,Kato S,Suzuki M

    更新日期:2011-04-01 00:00:00

  • Angiographic detection and characterization of "cryptic venous anomalies" associated with spinal cord cavernous malformations using flat-panel catheter angiotomography.

    abstract:BACKGROUND:Spinal cord cavernous malformations (CMs) are associated with 2 types of angiographically occult "cryptic venous anomalies," which differ in location with respect to the spinal cord. The anatomic distinction between superficial and intramedullary is important in that the latter heighten the risks of CM resec...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e31825d8f9a

    authors: Pearl MS,Chen JX,Gregg L,San Millàn D,Belzberg A,Jallo G,Gailloud P

    更新日期:2012-09-01 00:00:00

  • Neuropathy caused by spontaneous intraneural hemorrhage: case report.

    abstract::A case of ulnar neuropathy at the elbow produced by spontaneous intraneural hemorrhage in a patient with acquired immunodeficiency syndrome and thrombocytopenia is reported. Intraneural hemorrhage in patients with bleeding disorders occurs infrequently. It consists of acute intrafascicular bleeding, presumably produci...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199102000-00019

    authors: Poppi M,Staffa G,Martinelli P,Fabrizi AP,Giuliani G

    更新日期:1991-02-01 00:00:00

  • Reflections on a stereotactic and functional journey: the blessing and inspiration of working among giants.

    abstract::The author reports some of his early personal neurosurgical experiences spent among some of the great figures in neurosurgery and among some of the founders and pioneers of functional neurosurgery, stereotaxy, and clinical neurophysiology during the mid-1960s. This historical vignette represents recognition of the leg...

    journal_title:Neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.1227/01.neu.0000146208.22449.54

    authors: Marino R Jr

    更新日期:2005-01-01 00:00:00

  • Localization of stereotactic targets by microrecordings of thalamic somatosensory evoked potentials.

    abstract::To improve the localization of stereotactic targets, somatosensory evoked potentials (SEPs) were recorded from the thalamus and subthalamic area using a specially designed semimicroelectrode in 61 patients and a conventional "macroelectrode" in 17 patients. By means of the semimicroelectrode, median nerve stimulation ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199102000-00008

    authors: Shima F,Morioka T,Tobimatsu S,Kavaklis O,Kato M,Fukui M

    更新日期:1991-02-01 00:00:00

  • Extramedullary hematopoiesis in a malignant meningioma.

    abstract::An unusual case of malignant intracranial meningioma is presented. The operative management was complicated by the abrupt development of fulminant brain edema and herniation. The tumor contained areas of extramedullary hematopoiesis, a finding not previously reported. Various pathogenetic mechanisms involved in intrad...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198310000-00020

    authors: Gregorios JB,Bay JW,Dudley AW Jr

    更新日期:1983-10-01 00:00:00

  • Magnetic resonance imaging of symptomatic Rathke's cleft cyst: report of a case.

    abstract::A case of symptomatic Rathke's cleft cyst is described. In spite of the intrasellar component and radiological and clinical evidence of involvement of the pituitary gland, the sella turcica was minimally involved. MRI afforded optimal visualization and localization of the intra- and suprasellar components vis-à-vis th...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198902000-00021

    authors: Wagle VG,Nelson D,Rossi A,Uphoff D

    更新日期:1989-02-01 00:00:00

  • Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas.

    abstract:OBJECTIVE:Several studies have shown that human gliomas contain a small population of cells with stem cell-like features. It has been proposed that these "cancer stem cells" may be uniquely responsible for glioma formation and recurrence. However, human gliomas also contain an abundance of cells that closely resemble m...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000316019.28421.95

    authors: Ogden AT,Waziri AE,Lochhead RA,Fusco D,Lopez K,Ellis JA,Kang J,Assanah M,McKhann GM,Sisti MB,McCormick PC,Canoll P,Bruce JN

    更新日期:2008-02-01 00:00:00

  • Natural history of brainstem cavernous malformations.

    abstract:OBJECTIVE:To review the natural history and determine the rates of intra- and extralesional hemorrhaging of brainstem cavernous malformations (cavernomas) monitored by one neuro-ophthalmology service. METHODS:A record review of all patients with brainstem cavernomas who were evaluated by a neuroophthalmology service b...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200101000-00007

    authors: Kupersmith MJ,Kalish H,Epstein F,Yu G,Berenstein A,Woo H,Jafar J,Mandel G,De Lara F

    更新日期:2001-01-01 00:00:00

  • Defining Glioblastoma Resectability Through the Wisdom of the Crowd: A Proof-of-Principle Study.

    abstract:BACKGROUND:Extent of resection (EOR) correlates with glioblastoma outcomes. Resectability and EOR depend on anatomical, clinical, and surgeon factors. Resectability likely influences outcome in and of itself, but an accurate measurement of resectability remains elusive. An understanding of resectability and the factors...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000001374

    authors: Sonabend AM,Zacharia BE,Cloney MB,Sonabend A,Showers C,Ebiana V,Nazarian M,Swanson KR,Baldock A,Brem H,Bruce JN,Butler W,Cahill DP,Carter B,Orringer DA,Roberts DW,Sagher O,Sanai N,Schwartz TH,Silbergeld DL,Sisti M

    更新日期:2017-04-01 00:00:00

  • The effectiveness of interventions to reduce neurological injuries in rugby union: a systematic review.

    abstract:BACKGROUND:Rugby is characterized by high-speed collisions among the players that predispose them to injuries, particularly to the head, neck, and spine. OBJECTIVE:To evaluate the effectiveness of current neurological injury prevention strategies in rugby union. METHODS:Systematic review in May 2010. We assessed the ...

    journal_title:Neurosurgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1227/NEU.0b013e3181f209f1

    authors: Cusimano MD,Nassiri F,Chang Y

    更新日期:2010-11-01 00:00:00

  • Recurrent subarachnoid hemorrhage from untreated ruptured vertebrobasilar dissecting aneurysms.

    abstract::The clinical characteristics of vertebrobasilar dissecting aneurysms occurring with subarachnoid hemorrhage (SAH) were reviewed in 42 patients, with particular focus on the time, incidence, and outcome in association with subsequent rupture. Twenty-nine patients underwent 31 surgical procedures, and the remaining 13 p...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199505000-00003

    authors: Mizutani T,Aruga T,Kirino T,Miki Y,Saito I,Tsuchida T

    更新日期:1995-05-01 00:00:00

  • Aneurysm of the anterior inferior cerebellar artery-posterior inferior cerebellar artery variant: case report with anatomical description in the cadaver.

    abstract:OBJECTIVE AND IMPORTANCE:The authors report a very rare case of an aneurysm at the distal segment of the anterior inferior cerebellar artery-posterior inferior cerebellar artery (AICA-PICA) variant along with a description of the surgical anatomy of this variation in a cadaveric specimen. CLINICAL PRESENTATION:A 44-ye...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000199344.63306.DD

    authors: Baskaya MK,Coscarella E,Jea A,Morcos JJ

    更新日期:2006-02-01 00:00:00

  • Normal pressure hydrocephalus in children and young adults.

    abstract::Normal pressure hydrocephalus (NPH) is generally considered to be a disorder of adult and geriatric patients. We report four patients who are children or young adults with chronic neurological disorders, recent deterioration of their levels of function, normal cerebrospinal fluid (CSF) pressures, and ventricular enlar...

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    pub_type: 杂志文章

    doi:10.1227/00006123-198706000-00014

    authors: Barnett GH,Hahn JF,Palmer J

    更新日期:1987-06-01 00:00:00

  • Intraoperative computed tomography for complex craniocervical operations and spinal tumor resections.

    abstract:OBJECTIVE:To improve intraoperative observation of unexposed anatomic features and to verify surgical correction, a mobile computed tomographic (CT) scanner has been introduced into the operating room. To date, intraoperative CT scanning has been used predominantly for intracranial procedures. We report on the expanded...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200008000-00019

    authors: Hum B,Feigenbaum F,Cleary K,Henderson FC

    更新日期:2000-08-01 00:00:00

  • Vertebral artery-posteroinferior cerebellar artery aneurysms: clinical and lower cranial nerve outcomes in 52 patients.

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    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Al-khayat H,Al-Khayat H,Beshay J,Manner D,White J

    更新日期:2005-01-01 00:00:00

  • The Camino intracranial pressure sensor: is it optimal technology? An internal audit with a review of current intracranial pressure monitoring technologies.

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    pub_type: 杂志文章

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    authors: Piper I,Barnes A,Smith D,Dunn L

    更新日期:2001-11-01 00:00:00