Abstract:
:Using rabbit cerebral arteries in an in vitro chamber, we examined the cerebral arterial contraction initiated by clotting whole blood. By using methysergide maleate and a novel thromboxane synthetase inhibitor, 1-carboxyheptylimidazole (1-CHI), we studied the contributions of both serotonin and the prostaglandin metabolite thromboxane A2. Nontreated platelet-rich plasma (PRP) in the presence of methysergide produced a reliable contraction, whereas platelet-poor plasma did not. PRP from a rabbit pretreated with 1-CHI (50 mg/kg) compared to nontreated PRP caused a significantly smaller contraction. Blockade of this cerebral arterial contraction occurred without the disruption of platelet aggregation. Whole blood (1 ml) plus thrombin produced a consistent contraction over the 1 hour that was monitored. Whole blood drawn from a rabbit pretreated with 1-CHI (50 mg/kg) produced a smaller contraction, which began to dissipate in 5 minutes. When nontreated whole blood was added to the chamber in the presence of methysergide maleate (1.3 X 10(-5) g/ml), a contraction less than control was produced, and it persisted at 30 minutes. When whole blood pretreated with 1-CHI (50 mg/kg) was added to the chamber containing methysergide, there was a transient contraction that dissipated to nearly zero at 30 minutes. From our results, it is apparent that the thromboxane synthetase inhibitor has a profound effect on the later phase of blood-induced vasoconstriction. In contrast, the serotonin antagonist affected primarily the initial vasoconstriction and left the later phase largely unaltered. The role of thrombin, used to initiate coagulation, was also examined, and it was found to have a minimal direct constrictive effect when in a plasma solution.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Schumacher MA,Alksne JFsubject
Has Abstractpub_date
1981-09-01 00:00:00pages
275-82issue
3eissn
0148-396Xissn
1524-4040journal_volume
9pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract:OBJECTIVE:During its course between the brainstem and the lateral rectus muscle, the abducens nerve usually travels forward as a single trunk, but it is not uncommon for the nerve to split into two branches. The objective of this study was to establish the incidence and the clinical importance of the duplication of the...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000048186.18741.3c
更新日期:2003-03-01 00:00:00
abstract::This study examines the pathophysiology of stroke secondary to focal cerebral ischemia. The interaction of arachidonic acid metabolites and polyamines, a class of ubiquitous ornithine-derived molecules with important membrane effects on edema, Ca++-dependent endocytosis, platelet function, and prostaglandin (PG) forma...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198510000-00017
更新日期:1985-10-01 00:00:00
abstract:OBJECTIVE:Stereotactic radiosurgery is being used with more frequency in the management of patients with trigeminal neuralgia. To improve facial pain outcomes, many centers have increased the prescribed radiation dose to the trigeminal nerve. METHODS:Between April 1997 and December 1999, 68 patients underwent radiosur...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200107000-00008
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Meningiomas are the most common tumors occurring in the central nervous system, with variable recurrence rates depending on World Health Organization grading. Atypical (Grade II) meningioma has a higher rate of recurrence than benign (Grade I) meningioma. The efficacy of adjuvant radiotherapy (RT) to improve...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyaa348
更新日期:2020-12-15 00:00:00
abstract::: The US health care system is struggling with rising costs, poor outcomes, waste, and inefficiency. The Patient Protection and Affordable Care Act represents a substantial effort to improve access and emphasizes value-based care. Value in health care has been defined as health outcomes for the patient per dollar spen...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/NEU.0000000000000879
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To describe the neuropsychological functioning of children treated with surgery only for localized brain tumors in Dana-Farber Cancer Institute Protocol 92-077. Subsequent reports will describe the neuropsychological functioning of children treated with surgery and stereotactic radiation therapy on Dana-Farbe...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000064804.00766.62
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:Ollier disease (OD) and Maffucci syndrome are closely related, very rare syndromes, that are both associated with multiple sites of chondrodysplasia. They differ primarily with the additional association of Maffucci syndrome with vascular abnormalities, including hemangiomas. Both are associated with chondros...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/01.NEU.0000356984.92242.D5
更新日期:2009-12-01 00:00:00
abstract::A neoplastic cerebral aneurysm from lung cancer is an extremely rare occurrence despite its high metastatic potential to the brain. We report a neoplastic cerebral aneurysm from small-cell lung carcinoma that caused an intracerebral hematoma. A 63-year-old man underwent an urgent craniotomy for a massive intracerebral...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199301000-00019
更新日期:1993-01-01 00:00:00
abstract::We report a case of hyponatremia associated with volume depletion after pituitary exploration and biopsy. The presence of clinical dehydration precluded diagnosis of the syndrome of inappropriate secretion of antidiuretic hormone. The absence of a hypoadrenal state and the patient's response to volume reexpansion were...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198604000-00015
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:Pharmacological prophylaxis for venous thromboembolism (VTE) in the neurosurgical population is still a matter of debate, as the risk-to-benefit ratio is not well defined. OBJECTIVE:To further evaluate the risk-to-benefit ratio of VTE prophylaxis (VTEP) for all neurosurgical procedures. METHODS:A prospecti...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyy035
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Recent studies of age-related effects on cognition and performance have raised concerns about the appropriate timing and regulatory surveillance of retirement for surgeons. Little is known about the practice patterns and retirement plans of aging neurosurgeons. Analyses of informed opinions on possible regula...
journal_title:Neurosurgery
pub_type: 共识发展会议,杂志文章
doi:10.1227/01.NEU.0000349932.37540.02
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:The subarachnoid space consists of a number of distinct subarachnoid cisterns. They are separated from each other by trabecular walls, one of which is Liliequist's membrane. The aim of this study was to investigate the anatomic characteristics of Liliequist's membrane. METHODS:The study used a combined appro...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200010000-00021
更新日期:2000-10-01 00:00:00
abstract::From 1978 to 1988, 314 patients with malignant astrocytoma were treated by our neuro-oncology team. Twenty-five patients were excluded from further analysis because of a lack of adequate follow-up, the brain-stem location of the tumor, or an age of less than 18 years. Of the 289 remaining patients in the valid study g...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199402000-00002
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVE:The preoperative localization of superficial intracranial lesions is often necessary for accurate burr hole placement or craniotomy siting. It is not always easy, however, to localize the lesions over the scalp working only from computed tomographic images. We developed a simple method for such localization u...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200005000-00045
更新日期:2000-05-01 00:00:00
abstract::The object of this study was to determine whether the addition of information on brain stem reflexes improves the prognostic precision of the Glasgow coma scale for patients with severe head trauma. The study is based on 109 patients with a Glasgow coma score of 7 or less during the first 24 hours after injury. The av...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198505000-00002
更新日期:1985-05-01 00:00:00
abstract:OBJECTIVE:Animal model systems have shown that head trauma can induce cell death in regions of the brain away from the site of the impact via a process of apoptosis. We sought to determine whether there was evidence of cellular apoptosis in clinically collected materials from human head trauma patients, as well as to a...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200004000-00034
更新日期:2000-04-01 00:00:00
abstract::Cerebral vascular tone is modulated, at least in part, by the vascular endothelium. This probably results from a balance between the release of the endothelium-derived relaxing factor(s) and the endothelium-derived constricting factor(s) (e.g., endothelin). The time course of the induction and the decay of these mutua...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199005000-00013
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:Conflicting reports have been published with regard to the relationship between the efficacy of p53 gene therapy and the p53 status of gliomas. In this study, we evaluated whether U-87MG glioma cells harboring wild-type p53 and U251 and U-373MG glioma cells harboring mutated p53 demonstrate different sensitiv...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200107000-00027
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:Classic surgical exposures of the infratemporal fossa region, including the adjacent intracranial space, temporal bone, and sinonasal region, require the extensive exposure associated with the transcranial, transfacial, and transmandibular approaches with their inherent neurological and cosmetic morbidities. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000359224.75185.43
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:While multiple new larger-bore aspiration catheters have been introduced for stroke thrombectomy, sizeable cohort outcome studies are lacking along with meaningful comparative studies to evaluate whether they represent a clinically relevant improvement compared to predecessors. OBJECTIVE:To evaluate compara...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyaa498
更新日期:2020-12-28 00:00:00
abstract::The diagnosis of malignant glioma of the optic nerves and chiasm may be difficult because these rare lesions may mimic other suprasellar lesions. We report a case of glioblastoma multiforme of the optic chiasm in which the appearance of the lesion on computed tomographic (CT) scan was consistent with that of craniopha...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198212000-00011
更新日期:1982-12-01 00:00:00
abstract::The natural history of intracranial arteriovenous malformations (AVMs) was studied in 131 patients. The 83 patients managed nonsurgically and the 48 patients treated surgically were followed for an average of 8 years. Hemorrhage occurred in 61.8% of all patients. A second hemorrhage occurred in 67.4% of the survivors ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198411000-00003
更新日期:1984-11-01 00:00:00
abstract::An unusual association of a meningioma and an arteriovenous malformation is reported. A 68-year-old man developed left homonymous hemianopsia, left hemiparesis, and gaze palsy. Magnetic resonance imaging showed a right occipital mass lesion containing multiple signal-void areas with tubular and honeycomb appearance, s...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Endovascular stents have been successfully used in the treatment of fusiform and dissecting aneurysms of the peripheral circulation and extracranial carotid and vertebral arteries. Technical limitations related to the inability to navigate the stent and the delivery system through tortuous vasc...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199811000-00130
更新日期:1998-11-01 00:00:00
abstract::A case involving giant and multiple aneurysms of the distal posterior inferior cerebellar artery (PICA) is presented. Of the 130 reported cases of peripheral aneurysms of the PICA, 6 have been described as giant aneurysms and 5 have involved multiple aneurysms located on a single PICA. The occurrence of multiple aneur...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198802000-00005
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Biophysical modeling of glioma is gaining more interest for clinical practice. The most popular model describes aggressivity of tumor cells by two parameters: net proliferation rate (ρ) and propensity to migrate (D). The ratio ρ/D, which can be estimated from a single preoperative magnetic resonance imaging ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyw186
更新日期:2017-05-01 00:00:00
abstract::Neurosurgery in Uganda was virtually non-existent up until late 1960s. This changed when Dr. Jovan Kiryabwire spearheaded development of a neurosurgical unit at Mulago Hospital in Kampala. His work ethic and vision set the stage for rapid expansion of neurosurgical care in Uganda.At the beginning of the 2000s, Uganda ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyw159
更新日期:2017-04-01 00:00:00
abstract::Since the advent of magnetic resonance imaging, there has been renewed interest in disorders of cortical migration in the cause of focal epilepsy. The function of dysplastic cortex is poorly understood. We report a 46-year-old woman in whom this was assessed by intraoperative stimulation. This left-handed patient had ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199511000-00020
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Although real-time localization of gliomas has improved with intraoperative image guidance systems, these tools are limited by brain shift, surgical cavity deformation, and expense. OBJECTIVE:To propose a novel method to perform near-infrared (NIR) imaging during glioma resections based on preclinical and c...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000001450
更新日期:2016-12-01 00:00:00
abstract::Cushing's New Haven years were limited professionally to the completion of projects that had been previously started. These were the description of basophilism and the completion of the meningioma monograph and A Surgeon's Journal. His early years as a student at Yale led him to subsequent intense involvement in event...
journal_title:Neurosurgery
pub_type: 传,历史文章,杂志文章
doi:10.1097/00006123-199911000-00009
更新日期:1999-11-01 00:00:00