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Commercially available gas-permeable cell culture bags may not prevent anoxia in cultured or shipped islets.

Abstract：

:Prolonged anoxia has deleterious effects on islets. Gas-permeable cell culture devices can be used to minimize anoxia during islet culture and especially during shipment when elimination of gas-liquid interfaces is required to prevent the formation of damaging gas bubbles. Gas-permeable bags may have several drawbacks, such as propensity for puncture and contamination, difficult islet retrieval, and significantly lower oxygen permeability than silicone rubber membranes (SRM). We hypothesized that oxygen permeability of bags may be insufficient for islet oxygenation. We measured oxygen transmission rates through the membrane walls of three different types of commercially available bags and through SRM currently used for islet shipment. We found that the bag membranes have oxygen transmission rates per unit area about 100-fold lower than SRM. We solved the oxygen diffusion-reaction equation for 150-microm diameter islets seeded at 3000 islet equivalents per cm2, a density adequate to culture and ship an entire human or porcine islet preparation in a single gas-permeable device, predicting that about 40% of the islet volume would be anoxic at 22 degrees C and about 70% would be anoxic at 37 degrees C. Islets of larger size or islets accumulated during shipment would be even more anoxic. The model predicted no anoxia in islets similarly seeded in devices with SRM bottoms. We concluded that commercially available bags may not prevent anoxia during islet culture or shipment; devices with SRM bottoms are more suitable alternatives.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Avgoustiniatos ES,Hering BJ,Rozak PR,Wilson JR,Tempelman LA,Balamurugan AN,Welch DP,Weegman BP,Suszynski TM,Papas KK

doi

10.1016/j.transproceed.2008.01.059

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

395-400

issue

2

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(08)00107-3

journal_volume

40

pub_type

杂志文章

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