Clonal variation within a mucosal isolate derived from a patient with Leishmania (Viannia) braziliensis infection.

Abstract:

:Three isolates over 5 years from a patient with persistent relapsing mucosal leishmaniasis due to Leishmania (Viannia) braziliensis and 7 clones from one of these isolates were studied by zymodemes and serodemes analysis. Results showed evidences of clonal phenotypic variation. Eight isoenzymes markers demonstrated clear differences on Cellulose Acetate (CA) and thin starch gel electrophoresis. Also a panel of specific monoclonal antibodies showed such differences. Our observations provide additional evidence that Leishmania (Viannia) braziliensis is composed by subpopulations of parasites with peculiar biochemical and antigenic characteristics.

authors

Cuba-Cuba CA,Evans D,Rosa Ade C,Marsden PD

doi

10.1590/s0036-46651991000500002

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

343-50

issue

5

eissn

0036-4665

issn

1678-9946

journal_volume

33

pub_type

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