Hyperkeratosis lenticularis perstans (Flegel's disease). Case report and literature review.

abstract：BACKGROUND:For treatment of localized scleroderma numerous treatments, including ones with potentially hazardous side effects, are currently used with only limited success. OBJECTIVE:We attempted to determine the efficacy of low-dose UVA1 irradiation in patients with severe localized scleroderma. METHODS:Patients wer...

journal_title：Journal of the American Academy of Dermatology

authors： Kerscher M,Volkenandt M,Gruss C,Reuther T,von Kobyletzki G,Freitag M,Dirschka T,Altmeyer P

更新日期：1998-01-01 00:00:00

abstract：:Skin cancer is less prevalent in people of color than in the white population. However, when skin cancer occurs in non-whites, it often presents at a more advanced stage, and thus the prognosis is worse compared with white patients. The increased morbidity and mortality associated with skin cancer in patients of color...

journal_title：Journal of the American Academy of Dermatology

authors： Agbai ON,Buster K,Sanchez M,Hernandez C,Kundu RV,Chiu M,Roberts WE,Draelos ZD,Bhushan R,Taylor SC,Lim HW

更新日期：2014-04-01 00:00:00

abstract：:We describe a man with lichen planus pemphigoides. Direct immunofluorescence studies of peribullous skin showed linear deposition of IgG and C3 in the basement membrane zone. Indirect immunofluorescence studies disclosed circulating anti-basement membrane zone antibodies. Immunoelectron microscopy demonstrated binding...

journal_title：Journal of the American Academy of Dermatology

authors： Tamada Y,Yokochi K,Nitta Y,Ikeya T,Hara K,Owaribe K

更新日期：1995-05-01 00:00:00

abstract：:This is the second reported case of minocycline-induced Sweet's syndrome (and the first such case to appear in the American literature). The syndrome developed in a 32-year-old man 10 days after minocycline therapy for acne was begun and resolved rapidly after discontinuation of the medication and start of oral predni...

journal_title：Journal of the American Academy of Dermatology

authors： Thibault MJ,Billick RC,Srolovitz H

更新日期：1992-11-01 00:00:00

abstract：:Angiolymphoid hyperplasia with eosinophilia developed in a 13-year-old boy. The immune phenotype of infiltrating cells and the distribution of adhesion molecules of the integrin, immunoglobulin, and selectin families were analyzed with monoclonal antibodies. The infiltrate consisted mainly of helper lymphocytes, monoc...

journal_title：Journal of the American Academy of Dermatology

authors： von den Driesch P,Gruschwitz M,Schell H,Sterry W

更新日期：1992-05-01 00:00:00

abstract：:The acute complications that may result in failure of the surgical procedure are discussed. These include bleeding, hematoma, infection, dehiscence, and necrosis. The background of each is covered in detail and an attempt is made to show the interrelationships among them. The purpose of this communication is to aid in...

journal_title：Journal of the American Academy of Dermatology

authors： Salasche SJ

更新日期：1986-12-01 00:00:00

abstract：:Cicatricial pemphigoid is an autoimmune bullous disease that has a predilection for mucous membranes and often results in scarring. We describe a case of cicatricial pemphigoid with severe involvement of the glans penis, which, despite systemic therapy, led to phimosis. ...

journal_title：Journal of the American Academy of Dermatology

authors： Fueston JC,Adams BB,Mutasim DF

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Epidermolysis bullosa simplex is a skin-blistering disorder caused by mutations in keratin (K)14 or K5. Treatment with nuclear factor (erythroid-derived 2)-like 2 inducer sulforaphane ameliorated skin blistering in Krt14-null mice, correlating with induction of K17. To be therapeutically useful for epidermol...

journal_title：Journal of the American Academy of Dermatology

authors： Kerns ML,Guss L,Fahey J,Cohen B,Hakim JM,Sung S,Lu RG,Coulombe PA

更新日期：2017-03-01 00:00:00

abstract：:Fifteen patients with toxic epidermal necrolysis (TEN) were studied. In all of them the TEN was related to drug ingestion and believed to be drug-induced. The drugs implicated include pyrazolone derivatives, allopurinol, barbiturates, tetracycline, phenytoin, and penicillamine. Possible etiologic co-factors are infect...

journal_title：Journal of the American Academy of Dermatology

authors： Chan HL

更新日期：1984-06-01 00:00:00

abstract：:Talimogene laherparepvec (T-VEC) is an oncolytic virus based on herpes simplex virus type 1 approved for intralesional treatment of advanced melanoma. In this article, we review the clinical literature on T-VEC for advanced melanoma and provide a practical approach to using T-VEC in the dermatologic surgery and oncolo...

journal_title：Journal of the American Academy of Dermatology

authors： Haitz K,Khosravi H,Lin JY,Menge T,Nambudiri VE

更新日期：2020-07-01 00:00:00

abstract：:Cutaneous fungal infections are a major source of morbidity in HIV-infected patients, and their management poses special challenges. Superficial mycoses, such as tinea pedis, tinea cruris, tinea corporis, and onychomycosis, are no more common in HIV-infected patients than in the HIV-negative population but are of grea...

journal_title：Journal of the American Academy of Dermatology

authors： Elmets CA

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil (MMF) has enjoyed increasing popularity as an emerging immunosuppressant treatment for various autoimmune dermatologic conditions, including pyoderma gangrenosum (PG). OBJECTIVE:The aim of this study was to examine the efficacy and safety of MMF as used in PG. METHODS:A retrospective ...

journal_title：Journal of the American Academy of Dermatology

authors： Li J,Kelly R

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Melanoma in African Americans is rare, and the diagnosis is often delayed, leading to advanced presentation and poor prognosis. OBJECTIVE:The purpose of this retrospective study is to determine whether African American patients diagnosed with melanoma at the Washington Hospital Center were initially seen wi...

journal_title：Journal of the American Academy of Dermatology

authors： Byrd KM,Wilson DC,Hoyler SS,Peck GL

更新日期：2004-01-01 00:00:00

abstract：:Forty cases of lentigo maligna (LM) and lentigo maligna melanoma (LMM) treated by conventional fractionated radiotherapy are reviewed. Fourteen of seventeen LM patients are alive and well 4 months to 5 years following irradiation, one patient died of intercurrent disease without recurrence, and two had residual or rec...

journal_title：Journal of the American Academy of Dermatology

authors： Harwood AR

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Onychomycosis is an increasing problem with limited therapeutic options. OBJECTIVE:We evaluated the safety and efficacy, of oral terbinafine, a new fungicidal antimycotic, in patients with toenail onychomycosis. METHODS:A North American multicenter, double-blind, placebo-controlled study evaluated the myco...

journal_title：Journal of the American Academy of Dermatology

authors： Drake LA,Shear NH,Arlette JP,Cloutier R,Danby FW,Elewski BE,Garnis-Jones S,Giroux JM,Gratton D,Gulliver W,Hull P,Jones HE,Journet M,Krol AL,Leyden JJ,Maddin SC,Ross JB,Savin RC,Scher RK,Sibbald GR,Tawfik NH,Zaia

更新日期：1997-11-01 00:00:00

abstract：:The epidermal nevus syndrome is characterized by the association of epidermal nevi with abnormalities of the skin, skeletal system, central nervous system, eyes, and cardiovascular system, as well as with malignant conditions. We describe a 2-year-old girl with an extensive epidermal nevus involving the left side of t...

journal_title：Journal of the American Academy of Dermatology

authors： Tay YK,Weston WL,Ganong CA,Klingensmith GJ

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Pruritus has been associated with cancer. However, limited data are available on the types of underlying malignancies associated with pruritus. OBJECTIVE:We sought to characterize the association between pruritus and different cancer types, as well as variations by racial group. METHODS:Cross-sectional stu...

journal_title：Journal of the American Academy of Dermatology

authors： Larson VA,Tang O,Ständer S,Kang S,Kwatra SG

更新日期：2019-04-01 00:00:00

abstract：:The quest for effective strategies to treat obesity has propelled fat research into an exploration of the molecular processes that drive adipocyte formation, and hence body fat mass. The development of obesity is dependent on the coordinated interplay of adipocyte hypertrophy (increased fat cell size), adipocyte hyper...

journal_title：Journal of the American Academy of Dermatology

authors： Avram MM,Avram AS,James WD

更新日期：2007-03-01 00:00:00

abstract：:A 65-year-old woman treated with etretinate for pityriasis rubra pilaris developed chronic active hepatitis. The elevated transaminases were noted 2 months after initiation of therapy and peaked 2 months after discontinuation of etretinate. The spectrum of liver toxicity induced by etretinate is reviewed. We suggest t...

journal_title：Journal of the American Academy of Dermatology

authors： Sanchez MR,Ross B,Rotterdam H,Salik J,Brodie R,Freedberg IM

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:This study was undertaken to evaluate the effectiveness and safety of the 577 nm pulsed dye laser in the treatment of various vascular lesions of the face. OBJECTIVE:Our purpose was to make observations on the effects of different variables that could affect response. METHODS:Ninety-two adults with telangi...

journal_title：Journal of the American Academy of Dermatology

authors： Gonzalez E,Gange RW,Momtaz KT

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Topical corticosteroids alone or in combination with other therapies are widely used to treat mycosis fungoides (MF), but data on response rates to their use as monotherapy in MF are limited. OBJECTIVE:To evaluate the efficacy of topical corticosteroid monotherapy in MF; compare sex, age, stage distribution...

journal_title：Journal of the American Academy of Dermatology

authors： Kartan S,Shalabi D,O'Donnell M,Alpdogan SO,Sahu J,Shi W,Porcu P,Cha J,Nikbakht N

更新日期：2020-05-16 00:00:00

abstract：:To evaluate the sensitivity of histologic criteria 396 hematoxylin-eosin-stained step sections of 150 randomly sampled thin malignant melanomas (tumor thickness, less than or equal to 1.5 mm; level of invasion, I-III) were analyzed. The highest sensitivity was determined for nuclear atypia (84%), followed by the asymm...

journal_title：Journal of the American Academy of Dermatology

authors： Stolz W,Schmoeckel C,Welkovich B,Braun-Falco O

更新日期：1989-06-01 00:00:00

abstract：:Most clinicians agree that mycosis fungoides is the prototypic cutaneous T cell lymphoma. However, certain clinical characteristics indicate that this disorder may begin as a reactive rather than a neoplastic process. The concept of a nonneoplastic etiopathogenesis of mycosis fungoides is further supported by recent d...

journal_title：Journal of the American Academy of Dermatology

authors： Thiers BH

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:Gorlin-Goltz syndrome (GGS) is an autosomal-dominant disease characterized by the early onset of multiple basal cell carcinomas (BCCs), among other findings. Clinically, the BCCs may appear as soft pedunculated neoplasms that can be mistaken for true acrochordons. OBJECTIVE:We sought to describe the dermato...

journal_title：Journal of the American Academy of Dermatology

authors： Feito-Rodríguez M,Sendagorta-Cudós E,Moratinos-Martínez M,González-Beato MJ,de Lucas-Laguna R,Pizarro A

更新日期：2009-05-01 00:00:00

abstract：:A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3+4- 8+ large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8+ lymphocy...

journal_title：Journal of the American Academy of Dermatology

authors： Asada H,Okada N,Tei H,Yamamura T,Hashimoto K,Kondo K,Yamanishi K,Yoshikawa K

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:The increasing use of biologics is accompanied by a risk of hepatitis B (HBV) and C virus (HCV) reactivation. OBJECTIVE:To determine the predictors of HBV and HCV reactivation in psoriasis patients receiving biologics. METHODS:This study screened 2060 psoriasis patients (3562 treatment episodes) who were t...

journal_title：Journal of the American Academy of Dermatology

authors： Chiu HY,Chiu YM,Chang Liao NF,Chi CC,Tsai TF,Hsieh CY,Hsieh TY,Lai KL,Chiu TM,Wu NL,Hui RC,Lee CN,Wang TS,Chen PH,Yang CC,Huang YH

更新日期：2019-12-07 00:00:00

abstract：:Blood eosinophilia is a common feature of eosinophilic fasciitis and is variably reported in systemic sclerosis and localized scleroderma. Since these diseases share cutaneous fibrosis as the final outcome and have other clinical and pathologic features that are difficult to differentiate, the presence of blood eosino...

journal_title：Journal of the American Academy of Dermatology

authors： Falanga V,Medsger TA Jr

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Finasteride, a type II 5alpha-reductase inhibitor, reduces scalp and serum dihydrotestosterone and has been shown to be effective in men with androgenetic alopecia (AGA). OBJECTIVE:The purpose of this study was to determine the effect of finasteride on scalp hair weight in men with AGA. METHODS:Sixty-six m...

journal_title：Journal of the American Academy of Dermatology

authors： Price VH,Menefee E,Sanchez M,Ruane P,Kaufman KD

更新日期：2002-04-01 00:00:00

abstract：:Isotretinoin is used to treat severe and recalcitrant acne. Possible side effects include depression, suicide, and suicidal ideation; however, other studies suggest isotretinoin may improve mood and quality of life. Although iPLEDGE consenting warns about the risk of depression and suicidal ideation, there is no recom...

journal_title：Journal of the American Academy of Dermatology

authors： Schrom K,Nagy T,Mostow E

更新日期：2016-07-01 00:00:00

abstract：:Disseminated histoplasmosis is being diagnosed more frequently in persons infected with the human immunodeficiency virus and is often the initial manifestation of the acquired immunodeficiency syndrome (AIDS). Disease-related cutaneous features of HIV-associated disseminated histoplasmosis are defined as mucocutaneous...

journal_title：Journal of the American Academy of Dermatology

authors： Cohen PR,Bank DE,Silvers DN,Grossman ME

更新日期：1990-09-01 00:00:00