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Adverse respiratory and cardiovascular events attributed to timolol ophthalmic solution, 1978-1985.

Abstract：

:Between September 1978 and December 1985, 450 case reports of serious respiratory and cardiovascular events and 32 case reports of death attributed to ophthalmic timolol were received by the United States Food and Drug Administration and the National Registry of Drug-Induced Ocular Side Effects. Two hundred sixty-seven patients (55%) experienced a cardiac arrhythmia or a bronchospasm-related event. The median age was 68 years (n = 365). Fifty-five percent of the patients were women and 45% were men (n = 41). Of the 212 persons for whom medical history was provided, 129 (61%) had respiratory disease, 65 (31%) had cardiovascular disease, 13 (6%) had other illnesses, and five (2%) had no underlying illness. Of the 318 patients for whom data on duration of drug use were available 106 (33%) experienced their adverse event within one week of beginning timolol therapy: 73 (23%) had their events on the first day of therapy. Of 192 patients for whom information was available 177 (92%) improved after the drug was discontinued.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Nelson WL,Fraunfelder FT,Sills JM,Arrowsmith JB,Kuritsky JN

doi

10.1016/0002-9394(86)90532-5

subject

Has Abstract

pub_date

1986-11-15 00:00:00

pages

606-11

issue

5

eissn

0002-9394

issn

1879-1891

pii

0002-9394(86)90532-5

journal_volume

102

pub_type

杂志文章

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