Abstract:
:Every day, thousands of people in the United States receive polycyclic antidepressants (PCAs) prescribed by their primary care physicians. We have examined the cardiovascular manifestations of polycyclic antidepressants in 14 patients with primary depression receiving various antidepressant drugs for a period of six months or more. None had suffered from any systemic illness. All 14 received a commonly prescribed PCA, such as doxepin, amitriptyline, imipramine, desipramine or amoxapine, in therapeutic doses. None developed any significant adverse reaction. Left ventricular function, as determined by M-mode echocardiogram, was within normal limit in all patients. A twenty-four-hour ambulatory electrocardiogram revealed rare supraventricular ectopic beats in 8 patients and ventricular ectopic activity (Lown grade 1) in 4 patients. In 1 patient, who received additional lithium carbonate for treatment of depression, both supraventricular and ventricular ectopic activity developed on rare occasions. In 4 of the 8 patients the plasma concentration of PCA was optimal or near optimal, and in 4 of the 8 patients it was subtherapeutic (even though these 4 patients had shown clinical improvement with continued polycyclic therapy). It appears from the present data that antidepressant therapy with PCAs prescribed in therapeutic doses was well tolerated, without any significant adverse cardiovascular reaction, in otherwise healthy young patients with primary depression.
journal_name
Angiologyjournal_title
Angiologyauthors
Mahapatra RK,Paul SK,Mahapatra D,Winter Sdoi
10.1177/000331978603701003subject
Has Abstractpub_date
1986-10-01 00:00:00pages
709-17issue
10eissn
0003-3197issn
1940-1574journal_volume
37pub_type
杂志文章相关文献
ANGIOLOGY文献大全abstract::An 82-year-old man developed acute inferior myocardial infarction. Emergent coronary angiography demonstrated thrombotic occlusion in the right coronary artery. Intracoronary thrombolytic therapy was performed with successful recanalization. However, circumferential dissection with luminal stenosis was revealed at the...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979804900112
更新日期:1998-01-01 00:00:00
abstract::The authors retrospectively compared two groups of patients who had undergone angiography over a twenty-one-year period. The first group consisted of 348 patients who had angiography in the years 1965-1967. The second group was made up of 222 patients who had had angioplasty in the years 1975-1986. Special risk factor...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979304400306
更新日期:1993-03-01 00:00:00
abstract::The authors used the microcorrosion cast technique to study the localization and the role of pericytes in the microcirculation of skeletal muscle. Both fast twitch muscles, the tibialis anterior and the pectineus muscles, and a slow twitch one, the soleus muscle, were studied, because of morphological differences of t...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978503600708
更新日期:1985-07-01 00:00:00
abstract::Buflomedil hydrochloride (Buflomedil), a vasoactive drug, has been proven to improve pain-free walking distance in patients with peripheral arterial occlusive disease stage II of the lower extremities. In the present double-blind, randomized study, resting skin flux motion activity and skin flux response to a local he...
journal_title:Angiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/000331979804900203
更新日期:1998-02-01 00:00:00
abstract::Cardiac amyloidosis usually presents with heart failure, but rarely leads to coronary insufficiency. The authors report a case of a 69-year-old Japanese woman with cardiac amyloidosis presenting as microvascular angina. She had exertional angina with positive exercise test and normal coronary angiograms. However, hear...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970105200407
更新日期:2001-04-01 00:00:00
abstract::In a first experiment, an acute intravenous administration of 10 mg R 41 468, a pure serotonin-receptor blocking agent with high selectivity for blood vessels and thrombocytes and devoid of central effects, dramatically reduced systolic and diastolic blood pressure in 23 elderly hypertensive patients. Heart rate and c...
journal_title:Angiology
pub_type: 临床试验,杂志文章
doi:10.1177/000331978103200206
更新日期:1981-02-01 00:00:00
abstract::Dilated cardiomyopathy (DCM) carries a poor prognosis. This study examined the non-invasive parameters that may be predictive of survival in two groups of patients, short-term survivors who died within one year of onset of symptoms (Group I, 6 patients) and long-term survivors who survived greater than one year of pre...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978403500804
更新日期:1984-08-01 00:00:00
abstract::Arteriovenous (A-V) fistulae can be congenital or acquired. Acquired arteriovenous fistulae are met with during war as well as civilian practice as a result of penetrating injuries causing perforation in an artery and a vein which are surrounded usually by a firm sheath like the femoral, carotid or subclavian sheath, ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331977502600907
更新日期:1975-10-01 00:00:00
abstract::Sneddon's syndrome is a rare condition comprising widespread livedo retucularis and multiple episodes of transient cerebral ischemia. Treatment to date has been empirical. The hemostatic/thrombotic status of 4 patients with Sneddon's syndrome was studied by a unique technique, hemostatometry, which measures primary he...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979204300409
更新日期:1992-04-01 00:00:00
abstract::Until recently beta-adrenergic blocking agents were considered contraindicated in peripheral arterial occlusive disease (PAOD). However, in recent years several studies have failed to show negative effects on peripheral blood flow. It was the aim of this study to compare the effects of celiprolol, a beta-1-adrenergic ...
journal_title:Angiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/000331978703800403
更新日期:1987-04-01 00:00:00
abstract::We examined the relationship between coronary flow rate and epicardial adipose tissue (EAT) in patients with slow coronary flow (SCF) and normal coronary arteries. The study included 40 consecutive patients with stable angina pectoris who had normal coronary arteries. All patients underwent echocardiography. To determ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319711432452
更新日期:2012-11-01 00:00:00
abstract::The possibility that a familial background of hypertension might influence the blood pressure response to a calcium entry blocker was evaluated in 15 normotensive relatives of patients with essential hypertension and 18 normotensive subjects with no family history of hypertension. Under control conditions, blood press...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978703801203
更新日期:1987-12-01 00:00:00
abstract::To evaluate the aortic wall sclerosis in patients with coronary artery disease (CAD), the authors measured the aortic distensibility (AD) at the ascending and descending aorta by using cine magnetic resonance (MR). Cine MR was performed in 15 patients with CAD and 15 normal controls (NCs). Patients with CAD had angiog...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979604700206
更新日期:1996-02-01 00:00:00
abstract::Many, if not most antiarrhythmic drugs, even with differing pharmacologic properties, are capable of myocardial depression. That this has not occurred commonly with most drugs currently available may reflect several factors. These may include depression of myocardial function which is not clinically overt or which is ...
journal_title:Angiology
pub_type: 杂志文章,评审
doi:10.1177/000331978203300403
更新日期:1982-04-01 00:00:00
abstract::A sixty-seven-year-old woman was admitted with a complaint of atypical chest pain and with right precordial coved ST-T elevation, mimicking acute anterior myocardial infarction. Results of echocardiographic examination and a coronary angiographic study were normal. The etiology of her electrocardiographic pattern was ...
journal_title:Angiology
pub_type: 杂志文章,评审
doi:10.1177/000331979404500512
更新日期:1994-05-01 00:00:00
abstract::To determine the optimal cuff width for measuring toe blood pressure in patients with lower limb ischemia, this experimental prospective study examined 20 patients with symptoms of peripheral arterial disease referred for vascular examination or vascular surgery. Toe blood pressure was measured hydrostatically by the ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319706294606
更新日期:2007-08-01 00:00:00
abstract::Systolic time intervals and heart sounds were studied in twenty patients with left bundle branch block. A definite cause for the organic heart disease was not ascertained. Abnormal duration of the electromechanical systole (Q-A2), due to a prolongation both of the preejection period (PEP) and of the Q-M1 intervals, wa...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331977602700705
更新日期:1976-07-01 00:00:00
abstract::Platelet-derived growth factor (PDGF) and beta-thromboglobulin (beta-TG) are released from alpha granules during platelet activation. PDGF may play a role in the development of atherosclerosis and the late restenosis after percutaneous transluminal coronary angioplasty (PTCA). The effect of acetylsalicylic acid (ASA) ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979304400807
更新日期:1993-08-01 00:00:00
abstract::Kawasaki disease (KD) is an acute childhood febrile disease of unknown etiology. It exhibits not only coronary artery aneurysms in some cases but also systemic vasculitis. Whether KD is associated with accelerated atherosclerosis remains debatable. The measurement of pulse wave velocity (PWV) is useful as a simple, no...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319716651789
更新日期:2017-03-01 00:00:00
abstract::We have previously developed a technique for the in vivo visualization of the pulmonary arteries in the experimental animal with a fiberoptic instrument (angioscope). To assess the potential hemodynamic and gas exchange effects of angioscopy, we studied five dogs before and after pulmonary embolization. Sequential obs...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978403500205
更新日期:1984-02-01 00:00:00
abstract::Non-sustained ventricular tachycardia (VT) in the late post myocardial infarction (MI) period (7-21 days) has been reported to be a predictor of sudden death. We suspected that patients with 3 beat VT on Holter monitoring in the late infarction period would demonstrate electrical instability at electrophysiologic stud...
journal_title:Angiology
pub_type: 临床试验,杂志文章
doi:10.1177/000331978503600307
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND:A strong association exists between diabetes mellitus and critical limb ischemia. METHODS AND RESULTS:We performed endovascular therapy on 1060 limbs in 884 patients with below knee lesions only. The patients were divided into diabetes (DG) and nondiabetes groups (NDG). Limb salvage was poorer in the DG (79...
journal_title:Angiology
pub_type: 杂志文章,多中心研究
doi:10.1177/0003319713499606
更新日期:2020-05-01 00:00:00
abstract::Obesity is a major public health problem, with a prevalence of 10% to 20% in Western Europe. Morbid obesity, characterized by body mass index >40 kg/m(2), showed an increased prevalence in the last 30 years. Obesity is associated with reduced economic and social opportunities, reduced quality of life, and is a determi...
journal_title:Angiology
pub_type: 杂志文章,评审
doi:10.1177/0003319715595735
更新日期:2016-04-01 00:00:00
abstract::Peripheral neuropathy is often found in ischemic limbs with nondiabetic atherosclerotic peripheral vascular disease (PVD). Sensory symptoms such as burning pain are common in severely ischemic limbs, and sympathectomy has been undertaken for ischemic rest pain. The authors assessed noninvasive quantitative skin vasomo...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979804900303
更新日期:1998-03-01 00:00:00
abstract::The serum zinc concentration was examined in 61 patients with acute myocardial infarction who were admitted within twenty-four hours after the onset. Forty-two of 61 patients were admitted within twelve hours. The zinc level fell sharply as early as within three hours after the onset. The minimum values were attained ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979004100610
更新日期:1990-06-01 00:00:00
abstract::Microalbuminuria (UAE) may be considered a marker of systemic vascular dysfunction, while pulse pressure (PP) is an indicator of the stiffness of vascular conduits. Both these parameters, together with left ventricular hypertrophy (LVH), are linked to cardiovascular morbidity in hypertensive patients. The aim of this ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970105200303
更新日期:2001-03-01 00:00:00
abstract::Almost all angiomas fall into three main groups--hemangioma, lymphangioma, and glomangioma. Fifty-one such angiomas were found in approximately 7500 surgical specimens examined at a central laboratory serving the Igbos of Nigeria. The youngest patient was aged 19 days and the oldest 70 years. Most patients presented i...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331977702801110
更新日期:1977-11-01 00:00:00
abstract::The authors studied 17 cases of symptomatic arterial fibrodysplasia involving peripheral arteries without concomitant renovascular hypertension in Iranian males (age range: twenty-two to forty-five years). Affected arteries were most commonly the femoral, iliac, and popliteal, but in 2 cases the axillary and brachial ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978904000205
更新日期:1989-02-01 00:00:00
abstract::Several venotonic drugs have been used in the treatment of chronic venous insufficiency (CVI) of the lower limbs, most of them from natural sources. Calcium dobesilate, from synthetic origin, has been shown to improve clinical symptoms of these venous conditions. Three hundred fifty-two patients with CVI in grades I a...
journal_title:Angiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1177/000331970205300506
更新日期:2002-09-01 00:00:00
abstract::A 76-year-old man without any prior history of abnormal urinalysis findings or renal insufficiency demonstrated mild renal dysfunction after coronary bypass graft surgery (CABG). Two months after CABG, pain and blueness in the toes (blue toe syndrome) appeared and, the serum creatinine level (S-Cr) increased from 1.2 ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970605700316
更新日期:2006-05-01 00:00:00