Effects of antiarrhythmic agents on cardiac function.

Abstract:

:Many, if not most antiarrhythmic drugs, even with differing pharmacologic properties, are capable of myocardial depression. That this has not occurred commonly with most drugs currently available may reflect several factors. These may include depression of myocardial function which is not clinically overt or which is masked by preexisting cardiac decompensation, limitation of dosages because of the difficulty in accurately determining a therapeutic endpoint, and the lack of physician awareness of the effects of these drugs on myocardial performance. However, as techniques for monitoring and quantifying arrhythmia permit more aggressive drug therapy, and as more drugs become available for clinical use, the incidence of clinically overt myocardial depression from anti-arrhythmic therapy will undoubtedly rise. Hopefully, awareness of the hemodynamic effects of these drugs and applications of new technology permitting accurate, noninvasive assessment of left ventricular function will identify and hence limit the occurrence of toxic hemodynamic effects, as well as permit the usage of maximum dosages of antiarrhythmic drugs when warranted by clinical circumstances.

journal_name

Angiology

journal_title

Angiology

authors

Gottdiener JS,DiBianco R,Fletcher RD

doi

10.1177/000331978203300403

subject

Has Abstract

pub_date

1982-04-01 00:00:00

pages

228-38

issue

4

eissn

0003-3197

issn

1940-1574

journal_volume

33

pub_type

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