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Association of the shrinking lung syndrome in systemic lupus erythematosus with pleurisy: a systematic review.

Abstract：

OBJECTIVES:To report 2 patients with systemic lupus erythematosus and typical shrinking lung syndrome (SLS) in which pleuritic chest pain was the predominant symptom. In addition, to record the prevalence of pleuritic chest pain in all reported cases of patients with SLS and diaphragmatic dysfunction. METHODS:We conducted a comprehensive search of the English literature to record the association of pleurisy and SLS in all reported cases using the MEDLINE database from 1965 to present. RESULTS:Of the 77 patients with SLS reported in the literature, 50 (65%) patients had pleuritic chest pain at the time of evaluation. Treatment with anti-inflammatory agents improved symptoms in the majority of cases. CONCLUSIONS:Pleuritic inflammation and pain may have an important role in the pathogenesis of SLS. A possible mechanism linking pleural inflammation and diaphragm dysfunction may be via a reflex inhibition of diaphragmatic activation.

journal_name

Semin Arthritis Rheum

journal_title

Seminars in arthritis and rheumatism

authors

Toya SP,Tzelepis GE

doi

10.1016/j.semarthrit.2008.04.003

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

30-7

issue

1

eissn

0049-0172

issn

1532-866X

pii

S0049-0172(08)00083-8

journal_volume

39

pub_type

杂志文章,评审

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