Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases.

Abstract:

:The clinical course of 52 cases with eosinophilic fasciitis observed at the Mayo Clinic has been described. Cutaneous changes included pitting edema, peau d'orange, and induration, and may affect virtually any body surface area. In addition, localized morphea was present in 15 cases. Arthritis was observed in 21 patients; 29 patients had flexion contractures and 12 had carpal tunnel syndrome. Associated hematologic diseases were found in five patients; thrombocytopenia in two, myeloproliferative disorder in one, myelomonocytic leukemia in one, and chronic lymphocytic leukemia in one. Peripheral blood eosinophilia was noted in 33 of 52 patients, hypergammaglobulinemia was noted in 17 of 49, and elevated sedimentation rate was noted in 15 of 52. Nonspecific EMG changes were seen in 11 of 15 patients. None had clinical involvement of the kidneys, lungs, or heart. No significant association between any HLA-A, -B, or -DR and eosinophilic fasciitis was seen. Prednisone and hydroxychloroquine seemed equally beneficial in treatment; however, some cases showed spontaneous recovery, making evaluation of therapeutic efficacy difficult. Relapses occurred in some cases.

journal_name

Semin Arthritis Rheum

authors

Lakhanpal S,Ginsburg WW,Michet CJ,Doyle JA,Moore SB

doi

10.1016/0049-0172(88)90008-x

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

221-31

issue

4

eissn

0049-0172

issn

1532-866X

pii

0049-0172(88)90008-X

journal_volume

17

pub_type

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