Abstract：
OBJECTIVE:Describe the main activation and inhibitory pathways and receptors by which pDC regulate type I interferon secretion, as well as its association with autoimmune pathology. METHODS:A PubMed search for articles was conducted using the following key words: plasmacytoid dendritic cells, autoimmune diseases, viral infections and type I interferon. The search was limited to publications in English and from 1957 to 2012. Sixty-five of these articles are included in this review. The most relevant primary research articles identified were critically evaluated and compiled together. Particularly, areas of consensus and controversy were identified and analyzed. RESULTS:Plasmacytoid dendritic cells have been closely related to viral infections and autoimmune disease, mainly because of these immune cells are able to secrete large amounts of type I interferon. This function is linked with their expression of Toll-like receptors, specially TLR7 and TLR9, which are designed to sense nucleic acids in the early endosomes. Activated pDC can promote immunity and autoimmunity, however, the exact mechanisms by which pDC promote one vs. the other are not well understood. CONCLUSIONS:Plasmacytoid dendritic cells play a key role in both, immunity and autoimmunity. Current evidence suggests that the sustained overproduction of type-I interferon drives aberrant immune responses and the development of autoimmune pathology.
journal_name
Semin Arthritis Rheumjournal_title
Seminars in arthritis and rheumatismauthors
Santana-de Anda K,Gómez-Martín D,Soto-Solís R,Alcocer-Varela Jdoi
10.1016/j.semarthrit.2012.12.026subject
Has Abstractpub_date
2013-08-01 00:00:00pages
131-6issue
1eissn
0049-0172issn
1532-866Xpii
S0049-0172(13)00005-Xjournal_volume
43pub_type
杂志文章,评审abstract：OBJECTIVE:Infection is one of the major causes of morbidity and mortality in systemic lupus erythematosus (SLE) patients. We conducted a systematic review and meta-analysis to investigate the clinical characteristics and risk factors of infection in SLE by comparing demographic factors, laboratory data, clinical featur...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2020.06.004
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:To report entry criteria and clinical features of patients with newly diagnosed and relapsing giant cell arteritis (GCA) enrolled in a randomized trial of tocilizumab, an interleukin-6 receptor-alpha inhibitor. METHODS:Newly diagnosed GCA was defined as diagnosis ≤6 weeks before baseline. Relapsing GCA was d...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.semarthrit.2016.11.002
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:Air pollution ranks high among risk factors for the global burden of disease. The associations of air pollution and rheumatoid arthritis (RA) are controversial. This systematic review and meta-analyses has analyzed the association between outdoor air pollution and the development of RA. METHODS:PubMed, Emba...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2019.10.005
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVES:To conduct a systematic review of incidence and prevalence studies of rheumatoid arthritis (RA), based on the 1987 revised American College of Rheumatology (ACR) criteria, to compare their methodologies and summarize their results, and to investigate the possible geographic variations and changes over time i...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2006.08.006
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVE:The objective is to determine the relationship between clinical features and non-Hodgkin lymphoma (NHL) development in primary Sjögren's Syndrome (pSS), taking recently designed disease activity/severity scores into account. METHODS:Medical charts of pSS patients were retrospectively analyzed, scoring first ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2013.03.001
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVES:After detailing the different aspects of synovial inflammation (i.e., cellular, biochemical, and vascular) and based on the current knowledge, the aim of this review was to collect the available in vitro and in vivo data regarding the potency of some glycosaminoglycan (GAG) compounds to target synovial infla...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2013.10.005
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the outpatient health service utilisation of young people (YP) with juvenile idiopathic arthritis (JIA) during transfer from paediatric to adult care in Germany. METHODS:Based on claims data of a large German statutory health fund (BARMER GEK) we conducted a cohort study of 2008-2014. Insured YP ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2017.05.003
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVE:Neuropathic pain (NP) mechanisms contribute to the pain experience in osteoarthritis (OA). We aimed to characterise the factors that contribute to NP-like symptoms in knee OA patients. PATIENTS AND METHODS:A total of 139 patients with knee OA were recruited from secondary care, and completed a nurse- adminis...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2013.10.001
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVES:Dermatomyositis (DM) constitutes a subset of idiopathic inflammatory myopathies clinically characterized by proximal muscle weakness and skin involvement. Some of the dermatologic manifestations are highly prevalent and characteristic, but others such as generalized or limb edema are truly rare. The aim of t...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2014.04.004
更新日期：2014-10-01 00:00:00
abstract：:Mechanical injury is the most important risk factor in osteoarthritis (OA) development. Although once considered a passive disease of mechanical attrition, injury drives active mechanosensitive intracellular signalling which affects the structural and symptomatic course of disease. Mechanosensitive signalling in carti...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2019.09.018
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Autoimmune inner ear disease (AIED) was first described in 1979 and the disease has become more widely recognized over the last decade. Limited information is available regarding clinical features of the disease, disease course, and response to treatment. OBJECTIVE:To analyze data from 42 patients with docu...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2004.07.001
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:To examine the association between anti-Ro antibodies, namely anti-Ro60/SS-A and anti-Ro52/TRIM21, together and separately, and a prolonged QT interval corrected for heart rate (QTc) in systemic sclerosis (SSc) patients. METHODS:A total of 689 SSc patients enrolled in a multicenter cohort study underwent a 1...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,多中心研究
doi：10.1016/j.semarthrit.2014.07.001
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVES:Behçet's disease (BD) theoretically affects all sizes and types of vessels; however, there have been few reports describing the clinical efficacy of using (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with BD. METHODS:Eight patients who were registered at the BD Specialty Clini...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2010.05.006
更新日期：2011-04-01 00:00:00
abstract：:Traditional pain management strategies have relied on the use of opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen, as well as other adjuvant analgesics. However, the limited activity of these drugs and the substantial adverse effects associated with their use has left many patients without dep...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1053/sarh.2002.37218
更新日期：2002-12-01 00:00:00
abstract：:Rheumatoid joint destruction is caused by (1) enzymatic digestion from articular surfaces of cartilage, (2) pannus formation, and (3) lysis of the matrix by activated chondrocytes. Pannus, a vascular and fibrous granulation tissue arising from the perichondral synovial membrane, extends onto cartilage surfaces as a la...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/0049-0172(92)90058-l
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:To analyze the clinical, microbiological, and radiologic features of patients without drug addiction suffering from spontaneous pyogenic vertebral osteomyelitis. METHODS:We collected all microbiologically proved cases of pyogenic vertebral osteomyelitis seen between January 1980 and December 1999 in a teachi...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1053/sarh.2002.29492
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:Systemic sclerosis (SSc) is an autoimmune systemic disease characterized by diffuse fibrosis of skin and visceral organs due to different genetic, infectious, and/or environmental/occupational causative factors, including the inhalation of silica dust. OBJECTIVES:To investigate serum trace elements includin...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2018.06.009
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:We describe the first case of adult-onset Still's disease (AOSD) presenting with trochleitis and successfully treated with an interleukin-1 receptor antagonist. METHODS:This is a descriptive case report of one patient, identified in consultation with the inpatient ophthalmology consult service. RESULTS:A 2...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2013.09.003
更新日期：2014-04-01 00:00:00
abstract：:This study systematically reviewed commonly used patient-reported outcome measures (PROMs) for rheumatoid arthritis (RA), routinely collected in clinical practice, and evaluated objectives of their use. An additional survey conducted among identified RA registries provided additional information about collection of PR...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2018.03.006
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:To review the current status of collagen hydrolysate in the treatment of osteoarthritis and osteoporosis. METHODS:Review of past and current literature relative to collagen hydrolysate metabolism, and assessment of clinical investigations of therapeutic trials in osteoarthritis and osteoporosis. RESULTS:Hy...
journal_title：Seminars in arthritis and rheumatism
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1053/sarh.2000.9622
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVE:Few controlled studies are available to guide treatment decisions in juvenile dermatomyositis (JDM). This study evaluated therapies received, changes of treatment over time, and factors associated with medication choices in JDM. METHODS:We performed a retrospective analysis of the number and type of therapie...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2018.03.016
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:To report 3 cases ANCA-associated vasculitis (AAV) that developed in patients suffering from systemic sclerosis (SSc) and to review previously reported cases. METHODS:We describe 3 patients diagnosed with SSc who developed severe AAV that presented as crescentic glomerulonephritis (GN) and/or alveolar hemor...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2010.11.001
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:To describe the morbidity and mortality in Canadian scleroderma (SSc) patients focusing on gender, SSc type, and organ-specific prognosis in a cohort of patients seen from 1994 to 2004 in a Southwestern Ontario SSc clinic. We also compared this cohort to data from the literature, which showed that mean survi...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2008.06.002
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:Localized scleroderma is a skin fibrosing disorder that, if untreated, may result in severe disability. The purpose of this systematic review is to compare the present evidence concerning the effectiveness of Methotrexate versus phototherapy, alone or associated with Psoralen, in childhood localized scleroder...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,meta分析
doi：10.1016/j.semarthrit.2018.03.003
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:To report a case of biopsy-verified Wegener granulomatosis (WG) with positive c-antineutrophil cytoplasmic antibodies who had evidence of spleen infarction and to review the relevant literature on spleen involvement in WG. METHODS:Descriptive case report of 1 patient with WG complicated by spleen infarction ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2007.07.009
更新日期：2008-04-01 00:00:00
abstract：:Plant thorn synovitis (PTS) is an uncommon cause of monoarthritis. Seven cases of PTS were identified at our institution from January 1979 to July 1990, six of whom were men. Mean age was 27 years (range, 7 to 56 years). Symptoms included pain, swelling, and stiffness. Synovitis was present on examination along with d...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/0049-0172(91)90055-5
更新日期：1991-08-01 00:00:00
abstract：OBJECTIVE:This historical review summarizes the understanding of lupus erythematosus (LE) during the time of the career of William Osler and analyzes factors that may have retarded the clinical identification of this disease. METHODS:All of Osler's writings related to diseases that he defined as the "erythema group" w...
journal_title：Seminars in arthritis and rheumatism
pub_type： 传,历史文章,杂志文章
doi：10.1016/s0049-0172(97)80037-6
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVE:Central nervous system (CNS) involvement in primary Sjögren's syndrome (pSS) is controversial with regard to frequency, significance, and etiology. METHODS:We describe a young woman with pSS and severe CNS disease and review the literature on the pathophysiology, clinical significance, symptoms, diagnostic e...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/s0049-0172(99)80033-x
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVES:Massive refractory pleural effusions are uncommon in patients with systemic lupus erythematosus. Describing such a patient, the literature was reviewed to report the various therapeutic options in such cases. METHODS:MEDLINE search using the terms "lupus" and "pleural effusion," inclusion of cases with refr...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2004.11.003
更新日期：2005-04-01 00:00:00
abstract：:Gout, the most common inflammatory arthritis, is the result of hyperuricemia and inflammation induced by monosodium urate (MSU) crystal deposition. However, most people with hyperuricemia will never develop gout, implying a molecular-genetic contribution to the development of gout. Recent genomic studies reveal links ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2020.06.015
更新日期：2020-10-01 00:00:00
