Abstract：
OBJECTIVES:After detailing the different aspects of synovial inflammation (i.e., cellular, biochemical, and vascular) and based on the current knowledge, the aim of this review was to collect the available in vitro and in vivo data regarding the potency of some glycosaminoglycan (GAG) compounds to target synovial inflammation, an important aspect of osteoarthritis. METHODS:The first part of the review corresponds to a qualitative review of the inflammatory status of OA synovial membrane. The second part corresponds to a systematic review of the literature regarding the potential effects of some GAGs on the previously described phenomenon. RESULTS:The synovial aspect of the inflammatory status of OA has been detailed. Chondroitin sulfate has demonstrated to control the three aspects of synovial membrane inflammation: cell infiltration and activity, biochemical mediators release, and angiogenesis. Glucosamine is also active on both cellular and molecular aspects of the inflammatory reaction. Hyaluronic acid seems to be anti-inflammatory in its native form, while products of degradation are reported to be pro-angiogenic. CONCLUSION:Much evidence suggests that some of the studied GAG compounds could target different aspects of synovitis. Some of them could be considered in combination therapy since they exhibit complementary properties. Most of the studies have concentrated on articular cartilage and chondrocytes. In order to achieve a structure modification, one may now consider all joint tissues and investigate the drug potency on all of them. Potent treatment should trigger the most important features of OA: cartilage degradation, subchondral bone sclerosis, and all aspects of synovial inflammation.
journal_name
Semin Arthritis Rheumjournal_title
Seminars in arthritis and rheumatismauthors
Henrotin Y,Lambert C,Richette Pdoi
10.1016/j.semarthrit.2013.10.005subject
Has Abstractpub_date
2014-04-01 00:00:00pages
579-87issue
5eissn
0049-0172issn
1532-866Xpii
S0049-0172(13)00211-4journal_volume
43pub_type
杂志文章,评审abstract：:Subclinical alveolitis, as assessed by bronchoalveolar lavage (BAL) cell analysis, may be present in the lower respiratory tract of a high proportion of symptomless patients with connective tissue diseases (CTDs) with normal chest roentgenograms. The distribution of BAL cell types, mainly macrophages, lymphocytes, and...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/s0049-0172(97)80042-x
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVES:To contrast and compare the spectrum of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) with rheumatoid arthritis (RA) using an illustrative case. METHODS:The relevant English literature of RS3PE was searched using the keywords "RS3PE" alone and in combination with terms such as neop...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2008.11.006
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVES:To conduct a systematic review of incidence and prevalence studies of rheumatoid arthritis (RA), based on the 1987 revised American College of Rheumatology (ACR) criteria, to compare their methodologies and summarize their results, and to investigate the possible geographic variations and changes over time i...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2006.08.006
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVES:Retropharyngeal calcific tendinitis (RCT) is an under-recognized benign condition that results in significant neck pain and may mimic a retropharyngeal abscess (RPA). We describe the clinical presentation, diagnosis, and treatment of RCT as well as features that differentiate it from RPA. METHODS:We present...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2009.04.002
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:Osseous sarcoidosis has been infrequently reported. We aimed to characterize the distribution of lesions, clinical presentation, treatment, and outcomes for osseous sarcoidosis. METHODS:Cases of osseous sarcoidosis were identified by directed inquiry to clinicians and electronic query. Cases were defined as ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2014.07.003
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVES:To describe a systemic lupus erythematosus (SLE) patient with functional asplenia and antiphospholipid syndrome (APS) and to review the literature to better define its pathogenesis and diagnosis, emphasizing a possible relationship with antiphospholipid antibodies (aPL). METHODS:Descriptive report of 1 case...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/s0049-0172(03)00004-0
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVES:Dermatomyositis (DM) constitutes a subset of idiopathic inflammatory myopathies clinically characterized by proximal muscle weakness and skin involvement. Some of the dermatologic manifestations are highly prevalent and characteristic, but others such as generalized or limb edema are truly rare. The aim of t...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2014.04.004
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVES:To assess the interaction between the sympathetic and parasympathetic systems in patients with fibromyalgia syndrome (FM), using power spectrum analysis (PSA) of heart rate variability (HRV). In addition, we explored the association between HRV, measures of tenderness, FM symptoms, physical function, psychol...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/s0049-0172(00)80010-4
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVES:To estimate the size of unmet needs in the treatment of early Rheumatoid Arthritis (eRA), using all the conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and/or biological DMARDs (bDMARDs) in a long-term observational study. MATERIALS AND METHODS:538 patients with eRA were evaluated. T...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2018.06.003
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVES:Arthralgia is among the most frequent musculoskeletal symptoms occurring in patients with chronic lymphocytic thyroiditis (CLT), often causing pain and physical impairment over extended periods of time. Our study aims to characterize arthralgia and, in particular, polyarthralgia (PA) associated with CLT and ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1053/sarh.2002.33722
更新日期：2002-08-01 00:00:00
abstract：OBJECTIVE:To review the use of liposomes as a delivery agent in inflammatory arthritis. METHODS:The literature on liposomes and liposomal drug delivery for the treatment of inflammatory arthritis was reviewed. A PubMed search of articles in the English-language journals from 1965 to 2007 was performed. The index words...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2008.08.004
更新日期：2009-12-01 00:00:00
abstract：CONTEXT:Thoracic lymphadenopathy (LA) has been identified as a key prognostic factor in interstitial lung disease (ILD) of all-cause. Crystalline silica is a risk factor of systemic sclerosis (SSc). The association of a history of crystalline silica exposure with chest high-resolution computed tomography (HRCT) feature...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2020.08.014
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVES:To study the prevalence of connective tissue diseases (CTD) in patients with autoimmune hepatitis (AIH). METHODS:We identified 11 cases of AIH over the past 7 years at our institution, through a systematic chart review of patients with this diagnosis. Their charts were reviewed for the development of system...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2005.12.001
更新日期：2006-06-01 00:00:00
abstract：:Rheumatoid joint destruction is caused by (1) enzymatic digestion from articular surfaces of cartilage, (2) pannus formation, and (3) lysis of the matrix by activated chondrocytes. Pannus, a vascular and fibrous granulation tissue arising from the perichondral synovial membrane, extends onto cartilage surfaces as a la...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/0049-0172(92)90058-l
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:Comparison of naproxcinod (375 and 750 mg), placebo (up to 13 weeks), and naproxen 500 mg (all bid) for treatment of osteoarthritis (OA) signs and symptoms. METHODS:A 53-week, randomized, double-blind, parallel-group study. One thousand twenty patients with primary knee OA were randomized to naproxcinod 750 ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.semarthrit.2010.06.002
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Ankylosing spondylitis (AS) is a chronic inflammatory disorder that affects approximately 350,000 patients in the United States. Over time, the spinal and peripheral joint involvement of AS may cause severe disability and functional limitations. Research in the molecular and cellular events of AS has uncover...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2004.08.005
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVES:Studies employing voxel-based morphometry (VBM) have reported inconsistent findings on the association of gray matter (GM) abnormalities with fibromyalgia. The aim of the present study is to identify the most prominent and replicable GM areas that involved in fibromyalgia. METHODS:A systematic search of the...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,meta分析
doi：10.1016/j.semarthrit.2016.06.002
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVES:Massive refractory pleural effusions are uncommon in patients with systemic lupus erythematosus. Describing such a patient, the literature was reviewed to report the various therapeutic options in such cases. METHODS:MEDLINE search using the terms "lupus" and "pleural effusion," inclusion of cases with refr...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2004.11.003
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:To review the clinical features, diagnosis, treatment, and outcome of interferon-induced Raynaud's phenomenon. METHODS:The medical literature was reviewed from 1967 to November 2001 with the assistance of a MEDLINE search using the key words: Raynaud, Interferon, ischemia, thrombosis and necrosis. A qualitat...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1053/sarh.2002.34606
更新日期：2002-12-01 00:00:00
abstract：:The insert currently supplied with hydroxychloroquine states that patients should have an initial ophthalmological assessment and then regular assessments every 3 months. The rheumatologist should expect a report from the ophthalmologist, which includes a corneal assessment of tissue dose, a reference to visual field ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/s0049-0172(10)80009-5
更新日期：1993-10-01 00:00:00
abstract：OBJECTIVES:To examine the efficacy and safety of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) for the treatment of severe neutropenia due to Felty's syndrome (FS) or systemic lupus erythematosus (SLE). METHODS:Eight ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/s0049-0172(99)80040-7
更新日期：1999-10-01 00:00:00
abstract：OBJECTIVES:To provide an overview of the main nailfold capillaroscopy (NFC) changes described in dermatomyositis (DM) and polymyositis (PM) and to discuss the current evidence supporting its clinical relevance and applications in daily practice. METHODS:All relevant literature in the field of NFC and DM and PM publish...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2017.06.001
更新日期：2017-12-01 00:00:00
abstract：:Candida species are an uncommon cause of infectious arthritis, although the frequency has increased during recent years. Three cases of septic arthritis caused by Candida species are reported, and the literature is reviewed. The first patient developed a popliteal cyst infected by Candida albicans after multiple intra...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/0049-0172(93)80071-m
更新日期：1993-02-01 00:00:00
abstract：OBJECTIVE:To estimate rates of all-cause mortality, fatal infection, and fatal malignancy in rheumatoid arthritis (RA) patients treated with anti-tumor necrosis factor-α (anti-TNF) biologics. METHODS:A retrospective cohort study of RA patients initiating therapy with adalimumab, etanercept, or infliximab from January ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2012.05.004
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:Clinical trials indicate that denosumab could be a potential treatment for postmenopausal osteoporosis. The objective of this meta-analysis was to assess the clinical efficacy and safety of offering denosumab to postmenopausal women with low bone mass. METHODS:Data sources included MEDLINE, EMBASE, and Cochr...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,meta分析
doi：10.1016/j.semarthrit.2011.03.005
更新日期：2011-10-01 00:00:00
abstract：:The beneficial effects of the anti-tumor necrosis factor (TNF) monoclonal antibodies infliximab and adalimumab and the soluble receptor fusion protein etanercept in the treatment of rheumatoid arthritis and a variety of other inflammatory disorders have been well described. However, less is known about the propensity ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2005.01.005
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:Diabetes (DM) and osteoarthritis (OA) are two common co-existing chronic conditions. However, whether this is due to shared risk factors or may differ between joints is unclear. We performed a systematic review to determine whether abnormal glucose metabolism is a risk factor for knee, hip and hand OA, separa...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2018.02.008
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:Infection is one of the major causes of morbidity and mortality in systemic lupus erythematosus (SLE) patients. We conducted a systematic review and meta-analysis to investigate the clinical characteristics and risk factors of infection in SLE by comparing demographic factors, laboratory data, clinical featur...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2020.06.004
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVES:To study the association of clinical and/or ultrasound variables with patients' (PGA) and physicians' (EGA) global assessment of disease activity in psoriatic arthritis (PsA). The correlation of these parameters with the discordance between PGA and EGA, as well as with PGA/EGA changes over 6 months was also ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2016.05.010
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:To analyze the prevalence and characteristics of the main clinical, hematologic, and immunologic manifestations of systemic lupus erythematosus (SLE) in a cohort of 600 consecutive patients from a single center, and to determine the specific characteristics of organ involvement in a homogeneous SLE population...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1053/s0049-0172(03)00133-1
更新日期：2004-02-01 00:00:00
