Autosplenectomy and antiphospholipid antibodies in systemic lupus erythematosus: A pathogenetic relationship?

Abstract:

OBJECTIVES:To describe a systemic lupus erythematosus (SLE) patient with functional asplenia and antiphospholipid syndrome (APS) and to review the literature to better define its pathogenesis and diagnosis, emphasizing a possible relationship with antiphospholipid antibodies (aPL). METHODS:Descriptive report of 1 case and review of the literature by means of a MEDLINE search from 1966 to 2002. RESULTS:A SLE patient presented with cutaneous vasculitis and an unexpected thrombocytosis which resulted from autosplenectomy. Subsequently, she developed full-blown APS. In the literature, autosplenectomy has been described only in 1 other case of APS secondary to SLE. However, clinical or laboratory features linked to aPL occurred in several other cases among the 17 cases reported with functional asplenia. CONCLUSIONS:Autosplenectomy in SLE may be pathogenetically related to aPL. Thrombocytosis, unusual in SLE, may be a diagnostic clue of this condition. Pneumococcal vaccination is warranted to prevent life-threatening infections that frequently complicate this asplenia.

journal_name

Semin Arthritis Rheum

authors

Santilli D,Govoni M,Prandini N,Rizzo N,Trotta F

doi

10.1016/s0049-0172(03)00004-0

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

125-33

issue

2

eissn

0049-0172

issn

1532-866X

pii

S0049017203000040

journal_volume

33

pub_type

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