Abstract：
BACKGROUND:Ankylosing spondylitis (AS) is a chronic inflammatory disorder that affects approximately 350,000 patients in the United States. Over time, the spinal and peripheral joint involvement of AS may cause severe disability and functional limitations. Research in the molecular and cellular events of AS has uncovered a distinct role for the proinflammatory cytokine, tumor necrosis factor (TNF), in the pathogenesis of this disease. OBJECTIVES:This article reviews the role of TNF in the pathogenesis of AS and evaluates new therapeutic options for the disease. METHODS:Literature searches were conducted and various studies were reviewed and evaluated from the perspective of study design and validity of conclusions. Data are presented from animal studies and human clinical trials designed to test the efficacy of TNF inhibition in AS. RESULTS:The TNF inhibitors etanercept and infliximab not only demonstrate a significant reduction in the signs and symptoms of AS but also improve quality of life while reducing serious toxicities. Etanercept is the first TNF inhibitor to be approved by the United States Food and Drug Administration (FDA) for use in the treatment of AS and has recently been approved in the European Union. Infliximab has also been approved for use in the European Union. CONCLUSIONS:Early treatment with TNF inhibitors in patients with RA has been shown to result in significant improvements in disability, pain, and joint scores compared with delayed treatment. Ongoing trials are currently investigating whether these agents can halt or delay disease progression in patients with AS. RELEVANCE:Understanding the role of TNF inhibition in AS has led to new therapies that offer improved function and less disability for many patients suffering from this disease.
journal_name
Semin Arthritis Rheumjournal_title
Seminars in arthritis and rheumatismauthors
Davis JC Jrdoi
10.1016/j.semarthrit.2004.08.005subject
Has Abstractpub_date
2005-02-01 00:00:00pages
668-77issue
4eissn
0049-0172issn
1532-866Xpii
S0049017204001817journal_volume
34pub_type
杂志文章,评审abstract：BACKGROUND:Skeletal muscle involvement has been well documented in patients with polyarteritis nodosa (PAN), and symptoms referable to skeletal muscle are not uncommon. However, polymyositis as a mode of presentation of PAN is uncommon. This unusual presentation of PAN has been reported only once previously in the Engl...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1053/sarh.2002.32549
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVES:To present the data supporting the possible relationship of ocular toxoplasmosis to antitumor necrosis factor-alpha (TNF-alpha) therapy in patients with rheumatoid arthritis (RA). METHODS:A Medline search was performed using the words "toxoplasmosis, anti-TNF-alpha antagonists, chorioretinitis." We report 2...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2006.08.004
更新日期：2007-02-01 00:00:00
abstract：OBJECTIVE:To estimate rates of all-cause mortality, fatal infection, and fatal malignancy in rheumatoid arthritis (RA) patients treated with anti-tumor necrosis factor-α (anti-TNF) biologics. METHODS:A retrospective cohort study of RA patients initiating therapy with adalimumab, etanercept, or infliximab from January ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2012.05.004
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:To review the use of liposomes as a delivery agent in inflammatory arthritis. METHODS:The literature on liposomes and liposomal drug delivery for the treatment of inflammatory arthritis was reviewed. A PubMed search of articles in the English-language journals from 1965 to 2007 was performed. The index words...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2008.08.004
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:It has been well known that TNF-α inhibitor (TNFi) treatment for patients with rheumatoid arthritis (RA) is associated with anti-nuclear antibody (ANA) development. We previously reported that ANA development was associated with poor outcomes of infliximab (IFX) treatment (1). However, no replication studies...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2019.02.003
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:Behcet's disease (BD) is a systemic inflammatory disorder characterized by recurrent mucocutaneous ulcerations, ocular inflammation, and numerous severe systemic inflammatory manifestations. While most patients respond to standard immunosuppressive therapies, a subset will develop refractory disease. In this ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2010.12.002
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:Localized scleroderma is a skin fibrosing disorder that, if untreated, may result in severe disability. The purpose of this systematic review is to compare the present evidence concerning the effectiveness of Methotrexate versus phototherapy, alone or associated with Psoralen, in childhood localized scleroder...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,meta分析
doi：10.1016/j.semarthrit.2018.03.003
更新日期：2018-12-01 00:00:00
abstract：CONTEXT:Thoracic lymphadenopathy (LA) has been identified as a key prognostic factor in interstitial lung disease (ILD) of all-cause. Crystalline silica is a risk factor of systemic sclerosis (SSc). The association of a history of crystalline silica exposure with chest high-resolution computed tomography (HRCT) feature...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2020.08.014
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:Detailed analysis of hematological manifestations (HM) in systemic lupus erythematosus (SLE) are limited and their clinical impact on disease remain obscure. Here, we aimed to decipher factors associated with different hematological abnormalities in SLE patients and to assess their impact on disease related o...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2020.02.020
更新日期：2020-12-01 00:00:00
abstract：:Of an inception cohort of 87 patients with lupus nephritis who underwent a renal biopsy, 42 underwent second biopsies a median of 25 months later. From first to second biopsy, focal and diffuse proliferative nephritis (World Health Organization classes III and IV) became less frequent, and mesangial hypercellularity (...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/s0049-0172(05)80019-8
更新日期：1993-10-01 00:00:00
abstract：OBJECTIVE:Central nervous system (CNS) involvement in primary Sjögren's syndrome (pSS) is controversial with regard to frequency, significance, and etiology. METHODS:We describe a young woman with pSS and severe CNS disease and review the literature on the pathophysiology, clinical significance, symptoms, diagnostic e...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/s0049-0172(99)80033-x
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVE:(i) To determine the association between the presence of comorbidities and severity of pain and physical dysfunction in people with knee and/or hip osteoarthritis; (ii) to explore associations between specific comorbidities (cardiac disease and/or hypertension, diabetes, depression, and back pain) and symptom...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.semarthrit.2017.10.016
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:To analyze the clinical features, approaches to management, and outcome of spontaneous pyogenic facet joint infection (PFJI) in adults. PATIENTS AND METHODS:Case series of 10 adults with microbiologically proven PFJI diagnosed during a 10-year period in a teaching hospital, plus a review of 32 additional cas...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2005.09.003
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:Coronary artery involvement significantly increases mortality of patients with Takayasu arteritis (TA); however, the optimal revascularization strategy for this condition has not been established. We aimed to compare the long-term outcomes of TA patients with coronary artery involvement treated with coronary ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2017.03.009
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVES:To analyze if exercise interventions for patients with knee osteoarthritis (OA) following the American College of Sports Medicine (ACSM) definition of muscle strength training differs from other types of exercise, and to analyze associations between changes in muscle strength, pain, and disability. METHODS:...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.semarthrit.2017.03.007
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVES:Adult obesity may increase the risks of systemic lupus erythematosus (SLE), and there are genetic links between adult height and SLE. Thus, it is plausible that size earlier in life may be important in the aetiology of SLE as well. We investigated whether birthweight, childhood body mass index (BMI; [kg/m2])...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2020.01.011
更新日期：2020-12-01 00:00:00
abstract：:PH is an uncommon manifestation of SLE. The symptoms of PH develop within a few years after the onset of the multisystem disease. The most common presenting complaints of SLE patients with PH are dyspnea on exertion, chest pain, nonproductive cough, edema, and fatigue or weakness. The important physical findings are a...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/0049-0172(84)90015-5
更新日期：1984-05-01 00:00:00
abstract：:Immune disorders are characterized by development of autoantibodies. Autoantibodies, particularly antinuclear antibodies, are detected in the majority of patients with connective tissue diseases such as systemic lupus erythematosus and scleroderma. Recent reports have described persons with silicone implants who have ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/0049-0172(94)90110-4
更新日期：1994-08-01 00:00:00
abstract：:The authors examined the role of ultrasound (US) in diagnosis and management of heel pain in chronic inflammatory arthritis. Nineteen patients underwent US examination. Eight patients (2 with previously unsuccessful nonguided injections), had 11 US-guided corticosteroid injections for treatment of retrocalcaneal bursi...
journal_title：Seminars in arthritis and rheumatism
pub_type： 临床试验,杂志文章
doi：10.1016/s0049-0172(96)80003-5
更新日期：1996-06-01 00:00:00
abstract：OBJECTIVE:To conduct a systematic review and meta-analysis of the prevalence, incidence, and medication treatment of depression and anxiety among patients with psoriatic arthritis (PsA). METHODS:We searched Medline, Embase, Cochrane Database of Systematic Reviews, CINAHL and PsycINFO for full-length studies that: util...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2020.02.001
更新日期：2020-12-01 00:00:00
abstract：INTRODUCTION:Immune checkpoint inhibitors (ICIs) are a class of cancer immunotherapy, increasingly utilized to treat malignancies. Inflammatory arthritis (IA) is a potential consequence of ICI use, but there is limited information to guide evaluation and management of this immune-related adverse event (irAE). This stud...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2018.02.011
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the outpatient health service utilisation of young people (YP) with juvenile idiopathic arthritis (JIA) during transfer from paediatric to adult care in Germany. METHODS:Based on claims data of a large German statutory health fund (BARMER GEK) we conducted a cohort study of 2008-2014. Insured YP ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2017.05.003
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVES:To review published data on the perioperative management of antirheumatic treatment and perioperative outcome in patients with rheumatoid arthritis (RA). METHODS:The review is based on a MEDLINE (PubMed) search of the English-language literature from 1965 to 2005, using the index keywords "rheumatoid arthri...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2006.10.003
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVES:To evaluate the cardiovascular response to postural challenge in patients with chronic fatigue syndrome (CFS) and to determine whether the degree of instability of the cardiovascular response may aid in diagnosing CFS. METHODS:Patients with CFS (n = 25) and their age- and gender-matched healthy controls (n ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1053/sarh.2001.27738
更新日期：2001-12-01 00:00:00
abstract：:The insert currently supplied with hydroxychloroquine states that patients should have an initial ophthalmological assessment and then regular assessments every 3 months. The rheumatologist should expect a report from the ophthalmologist, which includes a corneal assessment of tissue dose, a reference to visual field ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/s0049-0172(10)80009-5
更新日期：1993-10-01 00:00:00
abstract：:The early course of newly diagnosed RA among young adult patients (16-44 yr) is described from results of an ongoing study with a mean follow-up of 3.4 yr. Study diagnosis was based on the judgement of experienced rheumatologists, and data on several hundred variables were obtained on entry and annually for the purpos...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/0049-0172(76)90013-5
更新日期：1976-05-01 00:00:00
abstract：OBJECTIVES:We undertook this study to determine the prevalence of hypovitaminosis D, its determinants, and its relationships to physical performance, serum parathyroid hormone (PTH) concentration, bone mineral density, and biochemical markers of bone turnover in healthy, ambulatory, pre- and postmenopausal women. METH...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2008.01.009
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVES:To estimate the prevalence, incidence, mortality, and predictors of cancer in patients with rheumatoid arthritis (RA). METHODS:We compared the incidence of cancer and the mortality by cancer in a cohort of 789 randomly selected RA patients (1999-2005) with the expected ones in the general population. We est...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,多中心研究
doi：10.1016/j.semarthrit.2007.08.006
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:A multidisciplinary expert panel, the Italian board for the TAilored BIOlogic therapy (ITABIO), was constituted to formulate evidence-based decisional statements for the first-line tailored biologic therapy in patient with rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA). MET...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2015.10.001
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory syndrome characterized by recurrent serositis or arthritis attacks and, in some patients, chronic subclinical inflammation that predisposes to secondary amyloidosis. Colchicine is the gold standard of treatment, which reduces attack frequenc...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2017.03.006
更新日期：2017-08-01 00:00:00
