Abstract：
OBJECTIVES:Adult obesity may increase the risks of systemic lupus erythematosus (SLE), and there are genetic links between adult height and SLE. Thus, it is plausible that size earlier in life may be important in the aetiology of SLE as well. We investigated whether birthweight, childhood body mass index (BMI; [kg/m2]), height and growth are associated with risks of adult SLE. METHODS:The study included 346,627 children from the Copenhagen School Health Records Register, born 1930-1996 with measured weights and heights from 7-13 years. Birthweight information was available from 1936. Linkages were made to the Danish National Patient Register for information on registrations of SLE. During follow-up, 435 individuals (366 women) were registered with SLE. Cox proportional hazards regressions were performed to estimate hazard ratios (HR) and 95% confidence intervals (CI). RESULTS:No differences by sex were detected in any of the associations. Birthweight was not associated with SLE risks. Childhood BMI and height were positively and linearly associated with SLE risks. For BMI at age 7, the HR was 1.11 (95% CI: 1.01-1.23) per z-score. For height at age 7, the HR was 1.13 (95% CI: 1.02-1.24) per z-score. The estimates were similar in magnitude across all childhood ages for BMI and height. There were limited indications that change in BMI or growth in height during childhood influence the risks of SLE in adulthood. CONCLUSIONS:Childhood body size is associated with risks of adult SLE, which supports the hypothesis that early life factors are important in SLE aetiology.
journal_name
Semin Arthritis Rheumjournal_title
Seminars in arthritis and rheumatismauthors
Thomas PE,Jensen BW,Sørensen KK,Jacobsen S,Aarestrup J,Baker JLdoi
10.1016/j.semarthrit.2020.01.011subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1507-1512issue
6eissn
0049-0172issn
1532-866Xpii
S0049-0172(20)30011-1journal_volume
50pub_type
杂志文章abstract：OBJECTIVES:To assess anti-TNF-α therapy response in uveitis associated with sarcoidosis refractory to conventional immunosuppressive therapy. METHODS:Open-label, multicenter, retrospective study on patients with sarcoid uveitis who underwent anti-TNF-α therapy because of inadequate response to conventional therapy inc...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,多中心研究
doi：10.1016/j.semarthrit.2015.05.010
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVES:Despite the use of stem cell transplantation (SCT) to treat inflammatory arthritis and other rheumatic diseases, case reports of the paradoxical development of these diseases after SCT are appearing. Three cases of inflammatory arthritis developing after SCT were seen at our institution, leading to a literat...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2008.03.010
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the outpatient health service utilisation of young people (YP) with juvenile idiopathic arthritis (JIA) during transfer from paediatric to adult care in Germany. METHODS:Based on claims data of a large German statutory health fund (BARMER GEK) we conducted a cohort study of 2008-2014. Insured YP ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2017.05.003
更新日期：2017-10-01 00:00:00
abstract：:Twenty-two patients with rheumatoid arthritis, 3 with seronegative juvenile rheumatoid arthritis, 4 with systemic lupus erythematosus, and 4 with psoriatic arthritis have undergone therapeutic pheresis at our institution over the last 3 yr. Lymphoplasmapheresis appears to be the most effective form of pheresis in trea...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/0049-0172(80)90001-3
更新日期：1980-11-01 00:00:00
abstract：OBJECTIVES:Dermatomyositis (DM) constitutes a subset of idiopathic inflammatory myopathies clinically characterized by proximal muscle weakness and skin involvement. Some of the dermatologic manifestations are highly prevalent and characteristic, but others such as generalized or limb edema are truly rare. The aim of t...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2014.04.004
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVE:The possibility that oral contraceptives offer a protective effect against the development of rheumatoid arthritis is still contentious. Of the 17 studies investigating this association, 11 have found a protective effect, and 6 have not. These differences are probably attributable to either selection or infor...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/s0049-0172(97)80025-x
更新日期：1997-06-01 00:00:00
abstract：:The efficacy and toxicity of cyclosporine in the treatment of patients with rheumatoid arthritis (RA) are reviewed. Most of the early trials were restricted to patients with intractable RA. The initial daily dose of cyclosporine was 5 to 10 mg/kg, which is now considered high. Of 283 cyclosporine-treated patients in n...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/0049-0172(92)90046-g
更新日期：1992-08-01 00:00:00
abstract：OBJECTIVE:Localized scleroderma is a skin fibrosing disorder that, if untreated, may result in severe disability. The purpose of this systematic review is to compare the present evidence concerning the effectiveness of Methotrexate versus phototherapy, alone or associated with Psoralen, in childhood localized scleroder...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,meta分析
doi：10.1016/j.semarthrit.2018.03.003
更新日期：2018-12-01 00:00:00
abstract：:The insert currently supplied with hydroxychloroquine states that patients should have an initial ophthalmological assessment and then regular assessments every 3 months. The rheumatologist should expect a report from the ophthalmologist, which includes a corneal assessment of tissue dose, a reference to visual field ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/s0049-0172(10)80009-5
更新日期：1993-10-01 00:00:00
abstract：:Of an inception cohort of 87 patients with lupus nephritis who underwent a renal biopsy, 42 underwent second biopsies a median of 25 months later. From first to second biopsy, focal and diffuse proliferative nephritis (World Health Organization classes III and IV) became less frequent, and mesangial hypercellularity (...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/s0049-0172(05)80019-8
更新日期：1993-10-01 00:00:00
abstract：OBJECTIVES:Retropharyngeal calcific tendinitis (RCT) is an under-recognized benign condition that results in significant neck pain and may mimic a retropharyngeal abscess (RPA). We describe the clinical presentation, diagnosis, and treatment of RCT as well as features that differentiate it from RPA. METHODS:We present...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2009.04.002
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVES:To describe the clinical presentation, diagnosis, classification, grading, evaluation of prognosis, and treatment of amyloidosis against the background of its pathomechanisms. METHODS:PubMed and MEDLINE databases (1990 to October 2007) and internet were searched for the key word amyloidosis and evaluated on...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2008.09.001
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVE:To ascertain the most reliable and relevant capillaroscopic measurements of nailfold videocapillaroscopy (NVC) by analyzing their inter- and intraobserver agreement and predictive value. METHODS:We studied 217 subjects (110 with Raynaud's phenomenon under ongoing evaluation, and 107 with connective tissue di...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2007.10.008
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory syndrome characterized by recurrent serositis or arthritis attacks and, in some patients, chronic subclinical inflammation that predisposes to secondary amyloidosis. Colchicine is the gold standard of treatment, which reduces attack frequenc...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2017.03.006
更新日期：2017-08-01 00:00:00
abstract：:Methotrexate therapy has been effective in the treatment of RA with short term experience suggesting little serious adverse reactions. Our review of 168 patients receiving methotrexate has identified nine patients with probable or possible methotrexate-induced pulmonary toxicity, giving a prevalence of 5% and an incid...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/0049-0172(87)90021-7
更新日期：1987-02-01 00:00:00
abstract：OBJECTIVE:To characterize levamisole-induced vasculopathy. METHODS:We performed a systematic review searching MEDLINE for articles published from 1972 to 2016. RESULTS:We retrieved 357 references and abstracts and selected 111 articles. Levamisole-induced vasculopathy was reported in 192 patients, with a female predo...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2018.07.010
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:To review the clinical features, diagnosis, treatment, and outcome of interferon-induced Raynaud's phenomenon. METHODS:The medical literature was reviewed from 1967 to November 2001 with the assistance of a MEDLINE search using the key words: Raynaud, Interferon, ischemia, thrombosis and necrosis. A qualitat...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1053/sarh.2002.34606
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:Comparison of naproxcinod (375 and 750 mg), placebo (up to 13 weeks), and naproxen 500 mg (all bid) for treatment of osteoarthritis (OA) signs and symptoms. METHODS:A 53-week, randomized, double-blind, parallel-group study. One thousand twenty patients with primary knee OA were randomized to naproxcinod 750 ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.semarthrit.2010.06.002
更新日期：2011-02-01 00:00:00
abstract：:Several indices have recently been constructed by rheumatologists for the assessment of clinical status in osteoarthritis of the extremities. These include the algofunctional indices for the hip and knee (Lequesne), the Western Ontario and McMasters Universities (WOMAC) index (Bellamy), patients and investigator's ove...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/0049-0172(91)90027-w
更新日期：1991-06-01 00:00:00
abstract：OBJECTIVE:To validate the ability of the American College of Rheumatology (ACR) clinical classification criteria and the ACR clinical plus radiographic classification criteria for osteoarthritis of the knee to predict articular cartilage damage. METHODS:Ninety subjects with knee osteoarthritis (OA) who were enrolled i...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.semarthrit.2005.06.002
更新日期：2005-12-01 00:00:00
abstract：OBJECTIVES:To evaluate the capacity of B-Mode ultrasonography (B-Mode US) and electron-beam computed tomography (EBCT) to detect arterial changes in Takayasu's arteritis. METHODS:EBCT angiography of the thoracoabdominal aorta and pulmonary artery, and B-mode US of large superficial arteries (common carotid, subclavian...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1053/sarh.2000.8375
更新日期：2000-08-01 00:00:00
abstract：:Gout, the most common inflammatory arthritis, is the result of hyperuricemia and inflammation induced by monosodium urate (MSU) crystal deposition. However, most people with hyperuricemia will never develop gout, implying a molecular-genetic contribution to the development of gout. Recent genomic studies reveal links ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2020.06.015
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:To report entry criteria and clinical features of patients with newly diagnosed and relapsing giant cell arteritis (GCA) enrolled in a randomized trial of tocilizumab, an interleukin-6 receptor-alpha inhibitor. METHODS:Newly diagnosed GCA was defined as diagnosis ≤6 weeks before baseline. Relapsing GCA was d...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.semarthrit.2016.11.002
更新日期：2017-04-01 00:00:00
abstract：:This report describes the natural history, clinical features, and therapeutic requirements of late-onset seropositive and/or erosive rheumatoid arthritis (LORA). One hundred twenty-nine patients with mean disease duration of 6 years and mean age of disease onset of 66 years were studied. All patients met American Rheu...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/s0049-0172(05)80038-1
更新日期：1993-12-01 00:00:00
abstract：:The clinical and laboratory features of six human immunodeficiency virus (HIV)-positive patients with atypical mycobacterial skeletal infections, seen at a county outpatient HIV facility or university outpatient clinic, are reviewed and compared with other reported cases. Atypical mycobacterial skeletal infections are...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/s0049-0172(96)80020-5
更新日期：1996-04-01 00:00:00
abstract：OBJECTIVES:To conduct a systematic review of incidence and prevalence studies of rheumatoid arthritis (RA), based on the 1987 revised American College of Rheumatology (ACR) criteria, to compare their methodologies and summarize their results, and to investigate the possible geographic variations and changes over time i...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2006.08.006
更新日期：2006-12-01 00:00:00
abstract：:The shoulder, a very common site of pain syndromes in medical practice, lends itself well to precise clinical analysis and identification of the pain-sensitive structure or structures. Once identified, rational and effective management can be applied, associated with predictably good prognosis. Early identification o...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/s0049-0172(77)80003-6
更新日期：1977-08-01 00:00:00
abstract：OBJECTIVE:Tumor necrosis factor (TNF) antagonists fall into 2 classes:etanercept (ETA) is a soluble TNF receptor, while infliximab (INF) and adalimumab (ADA) are monoclonal antibodies against TNF. All 3 drugs are effective in treating rheumatoid arthritis. However, these agents have been associated with an increased ri...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2006.02.001
更新日期：2006-12-01 00:00:00
abstract：:Rheumatoid pericarditis occurs in approximately one third of rheumatoid arthritis (RA) patients. However, clinically apparent rheumatoid pericarditis is infrequent. The authors found clinical pericarditis in 12 of 960 patients admitted for RA, 5 of whom had manifestations of cardiac compression. These 5 had longer dur...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/0049-0172(90)90056-l
更新日期：1990-12-01 00:00:00
abstract：OBJECTIVES:To study the prevalence of connective tissue diseases (CTD) in patients with autoimmune hepatitis (AIH). METHODS:We identified 11 cases of AIH over the past 7 years at our institution, through a systematic chart review of patients with this diagnosis. Their charts were reviewed for the development of system...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2005.12.001
更新日期：2006-06-01 00:00:00
