Clinical efficacy and safety of denosumab in postmenopausal women with low bone mineral density and osteoporosis: a meta-analysis.

Abstract:

OBJECTIVE:Clinical trials indicate that denosumab could be a potential treatment for postmenopausal osteoporosis. The objective of this meta-analysis was to assess the clinical efficacy and safety of offering denosumab to postmenopausal women with low bone mass. METHODS:Data sources included MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to February 3, 2010 and bibliographies of reviews. Randomized controlled trials comparing the efficacy and safety of denosumab to placebo for treatment of low bone mass (low bone mineral density or osteoporosis) in postmenopausal women were selected. Two reviewers independently abstracted data on study general characteristics and outcomes. Review Manager 5.0 software was used for data syntheses and meta-analysis. RESULTS:The database search revealed 4 studies (comprising 8864 patients randomized) that met the inclusion criteria and contributed to some or all of the meta-analysis outcomes. Relative risk (95% CI) of fractures for the denosumab compared with placebo group was 0.58 (0.52 to 0.66); relative risk (95% CI) of serious adverse events was 1.33 (0.83 to 2.14); relative risk (95% CI) of serious adverse events related to infection was 2.10 (0.64 to 6.90); relative risk (95% CI) of neoplasm was 1.11 (0.91 to 1.36); relative risk (95% CI) of study discontinuation due to adverse events was 1.10 (0.83 to 1.47); and relative risk (95% CI) of death was 0.78 (0.57 to 1.06). Findings remained robust to sensitivity analyses. CONCLUSION:Our analysis found a significant reduction in relative fracture risk in the denosumab compared with the placebo group.

journal_name

Semin Arthritis Rheum

authors

von Keyserlingk C,Hopkins R,Anastasilakis A,Toulis K,Goeree R,Tarride JE,Xie F

doi

10.1016/j.semarthrit.2011.03.005

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

178-86

issue

2

eissn

0049-0172

issn

1532-866X

pii

S0049-0172(11)00087-4

journal_volume

41

pub_type

杂志文章,meta分析
  • Association of metabolic syndrome with knee and hand osteoarthritis: A community-based study of women.

    abstract:OBJECTIVE:It is unclear whether the association between osteoarthritis (OA) and metabolic syndrome (MetS) varies with the site of the affected joint and the presence of pain. Our aim was to describe the association between MetS and radiographic OA (ROA) affecting the knee or the hand in the presence or absence of concu...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2018.07.007

    authors: Sanchez-Santos MT,Judge A,Gulati M,Spector TD,Hart DJ,Newton JL,Arden NK,Kluzek S

    更新日期:2019-04-01 00:00:00

  • Analysis of pharmacologic and nonpharmacologic prescription patterns of general practitioners and specialists in the AMICA study.

    abstract:OBJECTIVE:To evaluate the prescription modalities of general practitioners (GPs) and specialists in symptomatic osteoarthritis (OA) patients enrolled in the AMICA study. PATIENTS AND METHODS:This study started in 2001 as a cohort investigation of OA patients seen by 2764 GPs and 316 specialists. Enrolled were 28,981 p...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.semarthrit.2005.02.001

    authors: Scarpa R,Sarzi-Puttini P,Cimmino MA,Caporali R,Parazzini F,Zaninelli A,Canesi B

    更新日期:2005-08-01 00:00:00

  • Growth patterns in early juvenile idiopathic arthritis: Results from the Childhood Arthritis Prospective Study (CAPS).

    abstract:OBJECTIVES:To investigate early vertical growth patterns and factors associated with poor growth in a modern inception cohort of UK children with juvenile idiopathic arthritis (JIA) using data from the Childhood Arthritis Prospective Study (CAPS). METHODS:A study period of 3 years was chosen. Children included in this...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2017.11.002

    authors: McErlane F,Carrasco R,Kearsley-Fleet L,Baildam EM,Wedderburn LR,Foster HE,Ioannou Y,Chieng SEA,Davidson JE,Thomson W,Hyrich KL

    更新日期:2018-08-01 00:00:00

  • Polyarteritis nodosa presenting as polymyositis.

    abstract:BACKGROUND:Skeletal muscle involvement has been well documented in patients with polyarteritis nodosa (PAN), and symptoms referable to skeletal muscle are not uncommon. However, polymyositis as a mode of presentation of PAN is uncommon. This unusual presentation of PAN has been reported only once previously in the Engl...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1053/sarh.2002.32549

    authors: Plumley SG,Rubio R,Alasfar S,Jasin HE

    更新日期:2002-06-01 00:00:00

  • Vascular damage, fibrosis, and chronic inflammation in mechanical back pain problems.

    abstract::Our current hypothesis is that mechanical damage in the spine such as a disc prolapse can lead directly to pain. However, pain arising for this reason is usually of short duration. In many subjects, however, the mechanical problems lead to vascular damage and, in particular, venous obstruction and dilatation with endo...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/0049-0172(89)90020-6

    authors: Jayson MI

    更新日期:1989-05-01 00:00:00

  • Immunopathologic and clinical studies in pulmonary hypertension associated with systemic lupus erythematosus.

    abstract::PH is an uncommon manifestation of SLE. The symptoms of PH develop within a few years after the onset of the multisystem disease. The most common presenting complaints of SLE patients with PH are dyspnea on exertion, chest pain, nonproductive cough, edema, and fatigue or weakness. The important physical findings are a...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/0049-0172(84)90015-5

    authors: Quismorio FP Jr,Sharma O,Koss M,Boylen T,Edmiston AW,Thornton PJ,Tatter D

    更新日期:1984-05-01 00:00:00

  • The mediating role of pain and function in the association between stiffness and quality of life in patients with axial spondyloarthritis.

    abstract:OBJECTIVE:The relationship between stiffness and quality of life (QoL) remains unclear. We therefore aimed to examine the role of pain and function in linking stiffness and QoL in patients with axSpA. METHODS:We used cross-sectional data from a registry of axSpA patients in a tertiary referral centre to assess the lin...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2019.02.010

    authors: Kwan YH,Fong W,Cheng GHL,Phang JK,Leung YY,Lui NL,Thumboo J,Østbye T

    更新日期:2019-12-01 00:00:00

  • Risk profiling for a refractory course of giant cell arteritis: The importance of age and body weight: "Risk profiling for GC resistance in GCA".

    abstract:BACKGROUND:Giant cell arteritis (GCA) is a disease that relapses often, and some patients run a refractory course. Although prompt recognition of resistant GCA is a major issue, there is no well-recognized, baseline risk factor for poor response to glucocorticoid (GC) treatment. METHODS:We included all patients consec...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2020.09.009

    authors: Liozon E,Dumonteil S,Parreau S,Gondran G,Bezanahary H,Palat S,Ly KH,Fauchais AL

    更新日期:2020-12-01 00:00:00

  • Malignancy in psoriatic disease: Results from prospective longitudinal cohorts.

    abstract:OBJECTIVES:To estimate the prevalence and incidence of malignancy and its types in psoriatic arthritis (PsA) and psoriasis without arthritis (PsC) patients, in comparison to the general population, and to identify the predictive factors for developing cancer in psoriatic disease (PsD). METHODS:PsA patients followed pr...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2020.12.008

    authors: Polachek A,Muntyanu A,Lee KA,Ye JY,Chandran V,Cook RJ,Gladman DD

    更新日期:2020-12-24 00:00:00

  • Epidemiological aspects of Paget's disease: family history and relationship to other medical conditions.

    abstract::Some epidemiological aspects of Paget's disease were examined using questionnaires completed by 864 patients with physician-diagnosed Paget's disease and 500 controls of similar ages. Specifically studied were issues of familial aggregation of the disorder, history of exposure to certain infectious diseases, other med...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/0049-0172(94)90037-x

    authors: Siris ES

    更新日期:1994-02-01 00:00:00

  • Transition to adult rheumatology care is necessary to maintain DMARD therapy in young people with juvenile idiopathic arthritis.

    abstract:OBJECTIVE:To evaluate the outpatient health service utilisation of young people (YP) with juvenile idiopathic arthritis (JIA) during transfer from paediatric to adult care in Germany. METHODS:Based on claims data of a large German statutory health fund (BARMER GEK) we conducted a cohort study of 2008-2014. Insured YP ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2017.05.003

    authors: Luque Ramos A,Hoffmann F,Albrecht K,Klotsche J,Zink A,Minden K

    更新日期:2017-10-01 00:00:00

  • Indirect comparison of tocilizumab and other biologic agents in patients with rheumatoid arthritis and inadequate response to disease-modifying antirheumatic drugs.

    abstract:OBJECTIVES:To compare the patterns of American College of Rheumatology (ACR) response between tocilizumab and other biologic agents in patients with rheumatoid arthritis who have inadequate response to disease-modifying antirheumatic drugs (DMARD-IR). METHODS:Systematic literature review identified similarly designed ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/j.semarthrit.2009.12.002

    authors: Bergman GJ,Hochberg MC,Boers M,Wintfeld N,Kielhorn A,Jansen JP

    更新日期:2010-06-01 00:00:00

  • Spontaneous pyogenic facet joint infection.

    abstract:OBJECTIVE:To analyze the clinical features, approaches to management, and outcome of spontaneous pyogenic facet joint infection (PFJI) in adults. PATIENTS AND METHODS:Case series of 10 adults with microbiologically proven PFJI diagnosed during a 10-year period in a teaching hospital, plus a review of 32 additional cas...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2005.09.003

    authors: Narváez J,Nolla JM,Narváez JA,Martinez-Carnicero L,De Lama E,Gómez-Vaquero C,Murillo O,Valverde J,Ariza J

    更新日期:2006-04-01 00:00:00

  • Detection of cardiovascular system involvement in Behçet's disease using fluorodeoxyglucose positron emission tomography.

    abstract:OBJECTIVES:Behçet's disease (BD) theoretically affects all sizes and types of vessels; however, there have been few reports describing the clinical efficacy of using (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with BD. METHODS:Eight patients who were registered at the BD Specialty Clini...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2010.05.006

    authors: Cho SB,Yun M,Lee JH,Kim J,Shim WH,Bang D

    更新日期:2011-04-01 00:00:00

  • Epidemiological and clinical aspects relating to the variability of rheumatoid arthritis.

    abstract:OBJECTIVE:To review epidemiological studies dealing with the temporal and geographic variability in the occurrence of rheumatoid arthritis (RA) and clinical studies that address the variability of severity and manifestations among populations. METHODS:An extensive search of the literature, including a Medline search, ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/s0049-0172(97)80012-1

    authors: Abdel-Nasser AM,Rasker JJ,Valkenburg HA

    更新日期:1997-10-01 00:00:00

  • "To be or not to be," ten years after: evidence for mixed connective tissue disease as a distinct entity.

    abstract:OBJECTIVES:To determine if mixed connective tissue disease (MCTD) can be considered an independent clinical entity, to compare 3 different classification criteria for MCTD (Kasukawa, Alarcón-Segovia, and Sharp), and to define predictors (clinical features and autoantibodies) of potential evolution toward other connecti...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.semarthrit.2011.07.010

    authors: Cappelli S,Bellando Randone S,Martinović D,Tamas MM,Pasalić K,Allanore Y,Mosca M,Talarico R,Opris D,Kiss CG,Tausche AK,Cardarelli S,Riccieri V,Koneva O,Cuomo G,Becker MO,Sulli A,Guiducci S,Radić M,Bombardieri S,Ar

    更新日期:2012-02-01 00:00:00

  • The utility of lupus serology in predicting outcomes of renal transplantation in lupus patients: Systematic literature review and analysis of the Toronto lupus cohort.

    abstract:OBJECTIVES:To study the utility of lupus serology as a predictor for kidney graft outcome in (a) a systematic literature review (SLR) and (b) the Toronto lupus cohort (TLC). METHODS:For the SLR, a comprehensive literature search was performed to identify the articles reporting on the serology at renal transplantation ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2016.09.008

    authors: Yap KS,Urowitz MB,Mahood Q,Medina-Rosas J,Sabapathy A,Lawson D,Su J,Gladman DD,Touma Z

    更新日期:2017-06-01 00:00:00

  • Physical activity interventions among adults with arthritis: meta-analysis of outcomes.

    abstract:OBJECTIVE:Due to reduced physical activity, adults with arthritis experience significant disability and comorbidities including cardiovascular disease. This meta-analytic review integrates results from primary research studies testing interventions to increase physical activity in arthritis patients. METHODS:Extensive...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.semarthrit.2007.07.006

    authors: Conn VS,Hafdahl AR,Minor MA,Nielsen PJ

    更新日期:2008-04-01 00:00:00

  • Anti-nuclear antibody development is associated with poor treatment response to biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis.

    abstract:BACKGROUND:It has been well known that TNF-α inhibitor (TNFi) treatment for patients with rheumatoid arthritis (RA) is associated with anti-nuclear antibody (ANA) development. We previously reported that ANA development was associated with poor outcomes of infliximab (IFX) treatment (1). However, no replication studies...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2019.02.003

    authors: Ishikawa Y,Hashimoto M,Ito H,Tanaka M,Yukawa N,Fujii T,Yamamoto W,Mimori T,Terao C

    更新日期:2019-10-01 00:00:00

  • Pulmonary disease during the treatment of rheumatoid arthritis with low dose pulse methotrexate.

    abstract::Methotrexate therapy has been effective in the treatment of RA with short term experience suggesting little serious adverse reactions. Our review of 168 patients receiving methotrexate has identified nine patients with probable or possible methotrexate-induced pulmonary toxicity, giving a prevalence of 5% and an incid...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/0049-0172(87)90021-7

    authors: Carson CW,Cannon GW,Egger MJ,Ward JR,Clegg DO

    更新日期:1987-02-01 00:00:00

  • Ischemic stroke in a postpartum patient: understanding the epidemiology, pathogenesis, and outcome of Moyamoya disease.

    abstract:BACKGROUND:Moyamoya disease (MMD), or spontaneous occlusion of blood vessels in the circle of Willis, is a noninflammatory, nonatheromatous vasculopathy that often presents with ischemia or hemorrhage and has a tendency to affect young women. We discuss a case of a woman 7 days postpartum with new onset strokes, suspec...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/j.semarthrit.2005.09.001

    authors: Ishimori ML,Cohen SN,Hallegua DS,Moser FG,Weisman MH

    更新日期:2006-02-01 00:00:00

  • Serum Bisphenol A is an independent risk factor of hyperuricemia: A 6-year prospective study.

    abstract:OBJECTIVE:This study aims to evaluate whether serum Bisphenol A (BPA) is a risk factor for hyperuricemia. METHODS:In this prospective study, a total of 482 participants without hyperuricemia were enrolled at baseline and followed up for 6 years. Clinical characteristics were recorded, and serum levels of uric acid and...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2018.03.009

    authors: Hu J,Peng C,Li J,Gao R,Zhang A,Ma L,Zhang L,Yang Y,Cheng Q,Wang Y,Luo T,Wang Z,Qing H,Yang S,Li Q

    更新日期:2019-02-01 00:00:00

  • Determinants of morbidity and mortality of systemic sclerosis in Canada.

    abstract:OBJECTIVES:To describe the morbidity and mortality in Canadian scleroderma (SSc) patients focusing on gender, SSc type, and organ-specific prognosis in a cohort of patients seen from 1994 to 2004 in a Southwestern Ontario SSc clinic. We also compared this cohort to data from the literature, which showed that mean survi...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2008.06.002

    authors: Al-Dhaher FF,Pope JE,Ouimet JM

    更新日期:2010-02-01 00:00:00

  • Is abnormal glucose tolerance or diabetes a risk factor for knee, hip, or hand osteoarthritis? A systematic review.

    abstract:OBJECTIVE:Diabetes (DM) and osteoarthritis (OA) are two common co-existing chronic conditions. However, whether this is due to shared risk factors or may differ between joints is unclear. We performed a systematic review to determine whether abnormal glucose metabolism is a risk factor for knee, hip and hand OA, separa...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2018.02.008

    authors: Dawson LP,Fairley JL,Papandony MC,Hussain SM,Cicuttini FM,Wluka AE

    更新日期:2018-10-01 00:00:00

  • Tailored first-line biologic therapy in patients with rheumatoid arthritis, spondyloarthritis, and psoriatic arthritis.

    abstract:OBJECTIVE:A multidisciplinary expert panel, the Italian board for the TAilored BIOlogic therapy (ITABIO), was constituted to formulate evidence-based decisional statements for the first-line tailored biologic therapy in patient with rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA). MET...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/j.semarthrit.2015.10.001

    authors: Cantini F,Niccoli L,Nannini C,Cassarà E,Kaloudi O,Giulio Favalli E,Becciolini A,Biggioggero M,Benucci M,Li Gobbi F,Grossi V,Infantino M,Meacci F,Manfredi M,Guiducci S,Bellando-Randone S,Matucci-Cerinic M,Foti R,Di Gan

    更新日期:2016-04-01 00:00:00

  • Worldwide trends in the socioeconomic impact and long-term prognosis of rheumatoid arthritis.

    abstract::Rheumatoid arthritis (RA), once considered a benign and nonprogressive disease, is a debilitating condition with serious physical, emotional, and economic consequences. It afflicts approximately 1% of the adult population worldwide; prevalence increases with age, with twice as many women as men affected. In the United...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/0049-0172(91)90046-3

    authors: Markenson JA

    更新日期:1991-10-01 00:00:00

  • A reference case for economic evaluations in osteoarthritis: an expert consensus article from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).

    abstract:BACKGROUND:General recommendations for a reference case for economic studies in rheumatic diseases were published in 2002 in an initiative to improve the comparability of cost-effectiveness studies in the field. Since then, economic evaluations in osteoarthritis (OA) continue to show considerable heterogeneity in metho...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 共识发展会议,杂志文章

    doi:10.1016/j.semarthrit.2014.06.005

    authors: Hiligsmann M,Cooper C,Guillemin F,Hochberg MC,Tugwell P,Arden N,Berenbaum F,Boers M,Boonen A,Branco JC,Maria-Luisa B,Bruyère O,Gasparik A,Kanis JA,Kvien TK,Martel-Pelletier J,Pelletier JP,Pinedo-Villanueva R,Pinto D,

    更新日期:2014-12-01 00:00:00

  • Association of the shrinking lung syndrome in systemic lupus erythematosus with pleurisy: a systematic review.

    abstract:OBJECTIVES:To report 2 patients with systemic lupus erythematosus and typical shrinking lung syndrome (SLS) in which pleuritic chest pain was the predominant symptom. In addition, to record the prevalence of pleuritic chest pain in all reported cases of patients with SLS and diaphragmatic dysfunction. METHODS:We condu...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/j.semarthrit.2008.04.003

    authors: Toya SP,Tzelepis GE

    更新日期:2009-08-01 00:00:00

  • Comparative effectiveness and survival of infliximab, adalimumab, and etanercept for rheumatoid arthritis patients in the Hellenic Registry of Biologics: Low rates of remission and 5-year drug survival.

    abstract:OBJECTIVE:To compare effectiveness, drug survival, and safety between infliximab, adalimumab, and etanercept, in a nationwide cohort of rheumatoid arthritis (RA) patients. METHODS:This study is a prospective cohort study of 1208 active RA patients. Effectiveness, drug survival, and serious adverse events during entire...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2013.07.011

    authors: Flouri I,Markatseli TE,Voulgari PV,Boki KA,Papadopoulos I,Settas L,Zisopoulos D,Skopouli FN,Iliopoulos A,Bertsias GK,Geborek P,Drosos AA,Boumpas DT,Sidiropoulos P

    更新日期:2014-02-01 00:00:00

  • P2X7R: a potential key regulator of acute gouty arthritis.

    abstract:OBJECTIVES:Acute gouty arthritis is an inflammatory disease resulting from the precipitation of long-term hyperuricemia-induced monosodium urate (MSU) crystals in joints, which stimulates the production of interleukin-1beta (IL-1β) and initiates an inflammatory reaction. However, some patients having MSU crystals in th...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/j.semarthrit.2013.04.007

    authors: Tao JH,Zhang Y,Li XP

    更新日期:2013-12-01 00:00:00