Advances in our understanding of gout as an auto-inflammatory disease.

Abstract:

:Gout, the most common inflammatory arthritis, is the result of hyperuricemia and inflammation induced by monosodium urate (MSU) crystal deposition. However, most people with hyperuricemia will never develop gout, implying a molecular-genetic contribution to the development of gout. Recent genomic studies reveal links between certain genetic variations and gout. We highlight recent advances in our understanding of gout as an auto-inflammatory disease. We review the auto-inflammatory aspects of gout, including the inflammasome and thirteen gout-associated inflammatory-pathway genes and associated comorbidities. This information provides important insights into emerging immune-modulating targets in the management of gout, and future novel therapeutic targets in gout treatment. Cumulatively, this has important implications for treating gout as an auto-inflammatory disease, as opposed to a purely metabolic disease.

journal_name

Semin Arthritis Rheum

authors

Bodofsky S,Merriman TR,Thomas TJ,Schlesinger N

doi

10.1016/j.semarthrit.2020.06.015

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

1089-1100

issue

5

eissn

0049-0172

issn

1532-866X

pii

S0049-0172(20)30191-8

journal_volume

50

pub_type

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