Abstract：
BACKGROUND AND OBJECTIVES:Intra-articular (IA) hyaluronans (HAs) are indicated for pain relief of osteoarthritis (OA) of the knee. Hyalgan (sodium hyaluronate), Supartz (sodium hyaluronate), and Synvisc (hylan G-F 20) are Food and Drug Administration-approved HA products. They are derived from rooster combs; Hyalgan and Supartz are naturally derived (unmodified); Synvisc is chemically modified to increase its molecular weight. This article reviews and updates the safety data for IA HAs used for the treatment of knee OA. METHODS:References were taken from Medline through July 2002; respective product information services and information from the searchable United States Food and Drug Administration Manufacturer and User Facility Device Experience Database also were used. RESULTS:All products demonstrated favorable safety profiles in clinical trials and practice compared to other standard therapies for management of OA knee pain. The most common adverse event associated with HAs is mild injection site pain and swelling. Each product has had rare reports of pseudogout and anaphylactoid reactions. Product-specific adverse events, severe acute inflammatory reactions (pseudoseptic knee), in patients receiving Synvisc have been reported. One such patient developed antibodies to chicken proteins and hylan, suggesting an immunologic basis for the severe acute inflammatory reaction. Data from an animal study support a possible immunogenic difference between Synvisc and Hyalgan. CONCLUSIONS AND RELEVANCE:Overall, HA therapy is a safe treatment for OA knee pain, although there may be interproduct variability in safety profiles.
journal_name
Semin Arthritis Rheumjournal_title
Seminars in arthritis and rheumatismauthors
Hamburger MI,Lakhanpal S,Mooar PA,Oster Ddoi
10.1053/sarh.2002.50008subject
Has Abstractpub_date
2003-04-01 00:00:00pages
296-309issue
5eissn
0049-0172issn
1532-866Xpii
S0049017202701169journal_volume
32pub_type
杂志文章,评审abstract：OBJECTIVE:To identify if rheumatoid factor (RF) is predictor of response to rituximab (RTX), abatacept (ABT), and tocilizumab (TCZ) in rheumatoid arthritis (RA). METHODS:Systematic review and meta-analysis of clinical trials and observational studies based on a sensitive search. Meta-regression was used to explore cau...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.semarthrit.2012.11.007
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:Localized scleroderma is a skin fibrosing disorder that, if untreated, may result in severe disability. The purpose of this systematic review is to compare the present evidence concerning the effectiveness of Methotrexate versus phototherapy, alone or associated with Psoralen, in childhood localized scleroder...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,meta分析
doi：10.1016/j.semarthrit.2018.03.003
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:Dermatomyositis (DM) constitutes a subset of idiopathic inflammatory myopathies clinically characterized by proximal muscle weakness and skin involvement. Some of the dermatologic manifestations are highly prevalent and characteristic, but others such as generalized or limb edema are truly rare. The aim of t...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2014.04.004
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Familial arthropathy comprises a heterogeneous group of arthropathies. It can be either an inflammatory or a noninflammatory condition. The worldwide frequency of these disorders is unknown. OBJECTIVE:To study the demographic, clinical and biochemical features, and survival of a large series of children wit...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2006.08.008
更新日期：2007-02-01 00:00:00
abstract：:Candida species are an uncommon cause of infectious arthritis, although the frequency has increased during recent years. Three cases of septic arthritis caused by Candida species are reported, and the literature is reviewed. The first patient developed a popliteal cyst infected by Candida albicans after multiple intra...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/0049-0172(93)80071-m
更新日期：1993-02-01 00:00:00
abstract：OBJECTIVES:Studies employing voxel-based morphometry (VBM) have reported inconsistent findings on the association of gray matter (GM) abnormalities with fibromyalgia. The aim of the present study is to identify the most prominent and replicable GM areas that involved in fibromyalgia. METHODS:A systematic search of the...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,meta分析
doi：10.1016/j.semarthrit.2016.06.002
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVES:To study the association of clinical and/or ultrasound variables with patients' (PGA) and physicians' (EGA) global assessment of disease activity in psoriatic arthritis (PsA). The correlation of these parameters with the discordance between PGA and EGA, as well as with PGA/EGA changes over 6 months was also ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2016.05.010
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVES:To report 2 patients with systemic lupus erythematosus and typical shrinking lung syndrome (SLS) in which pleuritic chest pain was the predominant symptom. In addition, to record the prevalence of pleuritic chest pain in all reported cases of patients with SLS and diaphragmatic dysfunction. METHODS:We condu...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2008.04.003
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVES:Studies regarding the clinical features and outcomes of pediatric lupus nephritis are limited, and risk factors of poor outcome in the more severe form of renal involvement, proliferative lupus nephritis (PLN), are poorly understood. This study analyzed the data from a large prospective cohort of childhood s...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2013.07.005
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVES:Management of abscess-associated spontaneous pyogenic vertebral osteomyelitis (PVO) is controversial. The role of magnetic resonance imaging (MRI) in follow-up and its relation with clinical outcome is often unclear. This study evaluates the clinical and MRI outcome of abscess-associated PVO under conservati...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2007.08.007
更新日期：2008-08-01 00:00:00
abstract：:It is not widely appreciated that endocrine disease may present primarily as rheumatic syndromes, sometimes spectacular in onset, more commonly insidious and subtle, making their true recognition difficult. The underlying hormonal, biochemical, and metabolic events have understandable reflection in the structure and f...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/0049-0172(79)90002-7
更新日期：1979-08-01 00:00:00
abstract：OBJECTIVES:To systematically review the literature on the prevalence of Cognitive Dysfunction (CD) in SLE patients in studies that used a specified neuropsychological instrument. METHODS:This review was prepared with a protocol following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Protocols ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,meta分析
doi：10.1016/j.semarthrit.2018.02.007
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:To analyze the prevalence and characteristics of the main clinical, hematologic, and immunologic manifestations of systemic lupus erythematosus (SLE) in a cohort of 600 consecutive patients from a single center, and to determine the specific characteristics of organ involvement in a homogeneous SLE population...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1053/s0049-0172(03)00133-1
更新日期：2004-02-01 00:00:00
abstract：OBJECTIVES:To identify and describe measures that can be used to assess the impact of psoriatic arthritis (PsA) on patient functioning and health-related quality of life (HRQOL). METHODS:A literature search of the PubMed database to identify papers describing assessment tools for quality of life and function in rheuma...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2008.01.003
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVES:We describe the first case of adult-onset Still's disease (AOSD) presenting with trochleitis and successfully treated with an interleukin-1 receptor antagonist. METHODS:This is a descriptive case report of one patient, identified in consultation with the inpatient ophthalmology consult service. RESULTS:A 2...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2013.09.003
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:Comparison of naproxcinod (375 and 750 mg), placebo (up to 13 weeks), and naproxen 500 mg (all bid) for treatment of osteoarthritis (OA) signs and symptoms. METHODS:A 53-week, randomized, double-blind, parallel-group study. One thousand twenty patients with primary knee OA were randomized to naproxcinod 750 ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.semarthrit.2010.06.002
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVES:Aortic disease is a known complication of HLA-B27-associated spondyloarthritis. We present the case of a 52-year-old HLA-B27-positive woman with aortitis of the abdominal aorta and spondyloarthritis. METHODS:In addition to the case reported, a literature search (MEDLINE) for articles published between 1946 ...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2014.05.012
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:To identify patterns of maternal antibodies associated with an increased risk of having a child with congenital heart block (CHB) and to provide a basis for counseling women with a previously affected child. METHODS:This retrospective clinical study of the obstetric histories of 46 Finnish women with a CHB c...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/s0049-0172(98)80042-5
更新日期：1998-10-01 00:00:00
abstract：OBJECTIVES:Systemic lupus erythematosus (SLE) patients are at risk for complications that can be mitigated by appropriate preventive care. We examined the receipt of immunizations, cancer screening, and cardiovascular risk preventive services in a predominantly Black cohort of SLE patients from the Southeast U.S. To id...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2013.04.003
更新日期：2013-10-01 00:00:00
abstract：:Distinct profiles of autoantibodies directed to intracellular antigens can be detected in the systemic connective tissue diseases. They aid in establishing the correct diagnosis and are included in many sets of diagnostic criteria, such as the ones developed for systemic lupus erythematosus (anti-Smith antigen and ant...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/s0049-0172(95)80004-2
更新日期：1995-04-01 00:00:00
abstract：OBJECTIVES:To present the data supporting the possible relationship of ocular toxoplasmosis to antitumor necrosis factor-alpha (TNF-alpha) therapy in patients with rheumatoid arthritis (RA). METHODS:A Medline search was performed using the words "toxoplasmosis, anti-TNF-alpha antagonists, chorioretinitis." We report 2...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2006.08.004
更新日期：2007-02-01 00:00:00
abstract：:Subclinical alveolitis, as assessed by bronchoalveolar lavage (BAL) cell analysis, may be present in the lower respiratory tract of a high proportion of symptomless patients with connective tissue diseases (CTDs) with normal chest roentgenograms. The distribution of BAL cell types, mainly macrophages, lymphocytes, and...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/s0049-0172(97)80042-x
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVES:Air pollution ranks high among risk factors for the global burden of disease. The associations of air pollution and rheumatoid arthritis (RA) are controversial. This systematic review and meta-analyses has analyzed the association between outdoor air pollution and the development of RA. METHODS:PubMed, Emba...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章,评审
doi：10.1016/j.semarthrit.2019.10.005
更新日期：2020-04-01 00:00:00
abstract：:Of 500 patients with systemic lupus erythematosus observed at our center, 150 fulfilled criteria for lupus nephritis. Of these 150 patients, 91% were female, and 67% were white. The mean age of onset was 26.2 years, and the mean follow-up duration was 11.7 years. Biopsies (n = 142) performed on 107 patients showed the...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/s0049-0172(95)80017-4
更新日期：1995-08-01 00:00:00
abstract：OBJECTIVE:Amyloid deposition in multiple myeloma (MM) may lead to an arthropathy resembling rheumatoid arthritis (RA). Since a systematic description of its natural history is lacking, we have performed a systematic analysis of all published cases. METHODS:Literature review featuring backward and forward database sear...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2013.07.004
更新日期：2013-12-01 00:00:00
abstract：CONTEXT:Thoracic lymphadenopathy (LA) has been identified as a key prognostic factor in interstitial lung disease (ILD) of all-cause. Crystalline silica is a risk factor of systemic sclerosis (SSc). The association of a history of crystalline silica exposure with chest high-resolution computed tomography (HRCT) feature...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2020.08.014
更新日期：2020-10-01 00:00:00
abstract：:Twenty-two patients with rheumatoid arthritis, 3 with seronegative juvenile rheumatoid arthritis, 4 with systemic lupus erythematosus, and 4 with psoriatic arthritis have undergone therapeutic pheresis at our institution over the last 3 yr. Lymphoplasmapheresis appears to be the most effective form of pheresis in trea...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/0049-0172(80)90001-3
更新日期：1980-11-01 00:00:00
abstract：OBJECTIVE:To examine immunogenetic and clinical features in a series of patients with the idiopathic tubulointerstitial nephritis and uveitis (TINU) syndrome diagnosed at the single referral hospital for a defined population in Southern Spain. PATIENTS AND METHODS:Retrospective study of the case records of all patient...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1053/sarh.2002.33718
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:The predominant forms of adult large vessel vasculitis (LVV) are giant cell arteritis (GCA) and Takayasu arteritis (TA). Cardiac involvement in LVV is a cause of morbidity and mortality, particularly in TA. Cardiac failure is most commonly secondary to uncontrolled arterial hypertension or myocardial ischaem...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2017.03.023
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVE:Several studies have found an increased fall risk in persons with osteoarthritis (OA). However, most prospective studies did not use a clinical definition of OA. In addition, it is not clear which factors explain this risk. Our objectives were: (1) to confirm the prospective association between clinical OA of...
journal_title：Seminars in arthritis and rheumatism
pub_type： 杂志文章
doi：10.1016/j.semarthrit.2020.02.006
更新日期：2020-06-01 00:00:00
