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Oral contraceptives and rheumatoid arthritis: results from a primary care-based incident case-control study.

Abstract：

OBJECTIVE:The possibility that oral contraceptives offer a protective effect against the development of rheumatoid arthritis is still contentious. Of the 17 studies investigating this association, 11 have found a protective effect, and 6 have not. These differences are probably attributable to either selection or information biases in a subset of studies, although the exact reason is unknown. To overcome the methodological problems inherent in the design of previous studies, we have conducted a population-based case-control study. METHODS:Women who were incident cases of inflammatory polyarthritis, defined as swelling of at least two joint areas lasting at least 4 weeks, were recruited directly from primary care and compared with age-matched women from the same population. RESULTS:Cases and controls reported a similar level of "ever use" of oral contraceptives, adjusted odds ratio = 0.88 (95% confidence interval, 0.47, 1.64). The cases were, however, less likely to report using oral contraceptives at the time of onset, adjusted odds ratio = 0.22 (95% confidence interval, 0.06, 0.85). Similar results were observed for cases who satisfied the criteria for rheumatoid arthritis and cases who did not. CONCLUSION:These results indicate that only current oral contraceptive use protects against the development of inflammatory polyarthritis.

journal_name

Semin Arthritis Rheum

journal_title

Seminars in arthritis and rheumatism

authors

Brennan P,Bankhead C,Silman A,Symmons D

doi

10.1016/s0049-0172(97)80025-x

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

817-23

issue

6

eissn

0049-0172

issn

1532-866X

pii

S0049-0172(97)80025-X

journal_volume

26

pub_type

杂志文章,评审

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