Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity.

abstract：:Adult salicylate intoxication has been considered to be easily recognized and assciated with low morbidity and mortality. In the present study of 73 consecutive adults hospitalized with salicylate intoxication, 27% of patients were undiagnosed for as long as 72 h after admission. The initial physical findings and labo...

journal_title：Annals of internal medicine

authors： Anderson RJ,Potts DE,Gabow PA,Rumack BH,Schrier RW

更新日期：1976-12-01 00:00:00

abstract：PURPOSE:To review the clinical use of noninvasive positive pressure ventilation, including its efficacy with acute and chronic forms of respiratory failure, its mechanism of action, and its implementation. DATA SOURCES:Studies were identified through a MEDLINE search using the key words respiratory failure and mechani...

journal_title：Annals of internal medicine

authors： Meyer TJ,Hill NS

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:With suspected deep venous thrombosis and normal results on proximal vein ultrasonography, a negative d-dimer result may exclude thrombosis and a positive D-dimer result may be an indication for venography. OBJECTIVE:To evaluate and compare the safety of 2 diagnostic strategies for deep venous thrombosis. ...

journal_title：Annals of internal medicine

authors： Kearon C,Ginsberg JS,Douketis J,Crowther MA,Turpie AG,Bates SM,Lee A,Brill-Edwards P,Finch T,Gent M

更新日期：2005-04-05 00:00:00

abstract：OBJECTIVE:To validate prospectively the use of an artificial neural network to identify myocardial infarction in patients presenting to an emergency department with anterior chest pain. DESIGN:Prospective, blinded testing. SETTING:Tertiary university teaching center. PATIENTS:A total of 331 consecutive adult patient...

journal_title：Annals of internal medicine

authors： Baxt WG

更新日期：1991-12-01 00:00:00

abstract：PURPOSE:To review evidence about thyroxine suppressive therapy in patients with thyroid nodules, including the clinical importance and natural history of nodules and the effects and potential side effects of thyroxine therapy. DATA SOURCES:English-language articles published from 1986 to December 1996 were identified ...

journal_title：Annals of internal medicine

authors： Gharib H,Mazzaferri EL

更新日期：1998-03-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the usefulness of the continuous intravenous dexamethasone suppression test in the differential diagnosis of patients with the Cushing syndrome. DESIGN:Comparison of the results of this test with those of other tests in the study population and with data from the literature. SETTING:Refer...

journal_title：Annals of internal medicine

authors： Biemond P,de Jong FH,Lamberts SW

更新日期：1990-05-15 00:00:00

abstract：:Type 2 diabetes mellitus is a metabolic disease of carbohydrate metabolism. However, it should also be considered a vascular disease because diabetic patients have a strong predilection for atherosclerosis. With the increasing prevalence and earlier age at onset of diabetes, the projected effect of diabetes on cardiov...

journal_title：Annals of internal medicine

authors： Hurst RT,Lee RW

更新日期：2003-11-18 00:00:00

abstract：BACKGROUND:Hospitals are implementing discharge support programs to reduce readmissions, and these programs have had mixed success. OBJECTIVE:To examine whether a peridischarge, nurse-led intervention decreased emergency department (ED) visits or readmissions among ethnically and linguistically diverse older patients ...

journal_title：Annals of internal medicine

authors： Goldman LE,Sarkar U,Kessell E,Guzman D,Schneidermann M,Pierluissi E,Walter B,Vittinghoff E,Critchfield J,Kushel M

更新日期：2014-10-07 00:00:00

abstract：BACKGROUND:Screening can detect prostate cancer at earlier, asymptomatic stages, when treatments might be more effective. PURPOSE:To update the 2002 and 2008 U.S. Preventive Services Task Force evidence reviews on screening and treatments for prostate cancer. DATA SOURCES:MEDLINE (2002 to July 2011) and the Cochrane ...

journal_title：Annals of internal medicine

authors： Chou R,Croswell JM,Dana T,Bougatsos C,Blazina I,Fu R,Gleitsmann K,Koenig HC,Lam C,Maltz A,Rugge JB,Lin K

更新日期：2011-12-06 00:00:00

abstract：:Two kindreds affected by maturity-onset type of hyperglycemia in young people were studied. The postglucose-load hyperglycemia segregated as an autosomal dominant trait; it was always mild, never requiring insulin, and generally seemed to start in the first two decades of life. Glucose, insulin, glucagon, and growth h...

journal_title：Annals of internal medicine

authors： Barbosa J,Ramsay R,Goetz FC

更新日期：1978-05-01 00:00:00

abstract：:Plasma lipids were measured in 78 uremic patients receiving either chronic peritoneal dialysis or haemodialysis. Type IV hyperlipemia was found in 60% of patients. The lipid level was not influenced by dietary habits or patient's age. Patients on chronic peritoneal dialysis had a significantly higher and more sustaine...

journal_title：Annals of internal medicine

authors： Cattran DC,Fenton SS,Wilson DR,Steiner G

更新日期：1976-07-01 00:00:00

abstract：:In deciding whether to undertake a dietary program to reduce serum cholesterol levels, a person must consider how much benefit to expect. We developed a model that assumes cholesterol reduction is effective and safe in reducing the risk for death from ischemic heart disease. In the model, we considered asymptomatic ad...

journal_title：Annals of internal medicine

authors： Taylor WC,Pass TM,Shepard DS,Komaroff AL

更新日期：1987-04-01 00:00:00

abstract：:The 1950s witnessed prodigious growth in our knowledge of the chemical nature of the gene, the mechanisms by which the information inherent in its sequence of nucleotide units was conveyed to the cell's machinery for synthesizing proteins, and the mode of operation of that machinery. Watson and Crick raised the curtai...

journal_title：Annals of internal medicine

authors： Hoagland MB

更新日期：2003-04-01 00:00:00

abstract：:Multiple myeloma raises a number of puzzling questions about the production of immunoglobulins and the malignant transformation of lymphoid cells. Some of these questions can be approached by studying mouse plasmacytomas and by genetic and biochemical studies of mouse myeloma cells in culture. The synthesis, assembly,...

journal_title：Annals of internal medicine

authors： Weitzman S,Margulies DH,Scharff MD

更新日期：1976-07-01 00:00:00

abstract：:The exocrine pancreas secretes into the gut on demand more than 20 proteins that are indispensable for digestion. In-vivo autodigestion is prevented by an array of natural safeguards. In acute pancreatitis, inappropriate intrapancreatic activation and release of pancreatic hydrolases occur, but the pathogenetic mechan...

journal_title：Annals of internal medicine

authors： Geokas MC,Baltaxe HA,Banks PA,Silva J Jr,Frey CF

更新日期：1985-07-01 00:00:00

abstract：:A case of a patient with metastatic cancer raises the issues of patient refusal of treatment, euthanasia, and unintended side effects of therapy. For each management dilemma, there are relevant ethical and legal considerations, justifications, and conclusions. In addition, psychological and social influences on the de...

journal_title：Annals of internal medicine

authors： Lo B,Jonsen AR

更新日期：1980-01-01 00:00:00

abstract：Background:The 2013 pooled cohort equations (PCEs) are central in prevention guidelines for cardiovascular disease (CVD) but can misestimate CVD risk. Objective:To improve the clinical accuracy of CVD risk prediction by revising the 2013 PCEs using newer data and statistical methods. Design:Derivation and validation ...

journal_title：Annals of internal medicine

authors： Yadlowsky S,Hayward RA,Sussman JB,McClelland RL,Min YI,Basu S

更新日期：2018-07-03 00:00:00

abstract：:The clinical significance of anatomic substage was assessed in 130 patients with Hodgkin's disease in pathologic stage III-A: stage III1-A includes involvement of spleen, or splenic, celiac, or portal nodes, or any combination of these; stage III2-A includes involvement of para-aortic, iliac, or mesenteric nodes, with...

journal_title：Annals of internal medicine

authors： Stein RS,Golomb HM,Diggs CH,Mauch P,Hellman S,Wiernik PH,Ultmann JE,Rosenthal DS

更新日期：1980-02-01 00:00:00

abstract：:Concierge medical practices, which advertise expanded access to care and individualized attention, collect charges both from insurance companies and directly from their patients. Some bill hundreds of dollars for one-time "executive" physicals, whereas others have patients pay annual retainer fees. Yet, virtually no d...

journal_title：Annals of internal medicine

authors： Stillman M

更新日期：2010-03-16 00:00:00

abstract：BACKGROUND:Changes in federal health policy are providing more access to medical care for persons with chronic disease. Providing quality care may require a team approach, which the American College of Physicians calls the "medical home." One new model may involve nurse-managed protocols. PURPOSE:To determine whether ...

journal_title：Annals of internal medicine

authors： Shaw RJ,McDuffie JR,Hendrix CC,Edie A,Lindsey-Davis L,Nagi A,Kosinski AS,Williams JW Jr

更新日期：2014-07-15 00:00:00

abstract：:Young adults with cystic fibrosis have lower blood pressures than control subjects of similar age and sex. The low blood pressure may be related to the excessive loss of salt in the sweat of these patients. A beneficial effect of the cystic fibrosis gene may be protection against developing hypertension in both the ho...

journal_title：Annals of internal medicine

authors： Lieberman J,Rodbard S

更新日期：1975-06-01 00:00:00

abstract：:Pemphigus is an autoimmune intraepidermal bullous disease involving the skin and mucous membranes. There are four clinically recognized variants of this disease. The histopathologic hallmark is acantholysis, which is disruption of normal cell-to-cell adhesion. Patients produce an IgG antibody directed against an antig...

journal_title：Annals of internal medicine

authors：

更新日期：1980-03-01 00:00:00

abstract：BACKGROUND:Travelers' diarrhea causes substantial morbidity and postinfectious irritable bowel syndrome. OBJECTIVE:To evaluate nonabsorbable rifaximin for prevention of travelers' diarrhea. DESIGN:Randomized, double-blind, placebo-controlled clinical trial. SETTING:Guadalajara, Mexico. PARTICIPANTS:U.S. students. ...

journal_title：Annals of internal medicine

authors： DuPont HL,Jiang ZD,Okhuysen PC,Ericsson CD,de la Cabada FJ,Ke S,DuPont MW,Martinez-Sandoval F

更新日期：2005-05-17 00:00:00

abstract：BACKGROUND:Short-term aspirin therapy can lower the risk for venous thromboembolism (VTE) in high-risk patients, but whether the long-term use of low-dose aspirin reduces risk in healthy adults is uncertain. OBJECTIVE:To test the efficacy of long-term aspirin therapy for preventing VTE. DESIGN:Secondary analysis of a...

journal_title：Annals of internal medicine

authors： Glynn RJ,Ridker PM,Goldhaber SZ,Buring JE

更新日期：2007-10-16 00:00:00

abstract：BACKGROUND:Clinical trial registries are in widespread use to promote transparency around trials and their results. OBJECTIVE:To describe characteristics of drug trials listed in ClinicalTrials.gov and examine whether the funding source of these trials is associated with favorable published outcomes. DESIGN:An observ...

journal_title：Annals of internal medicine

authors： Bourgeois FT,Murthy S,Mandl KD

更新日期：2010-08-03 00:00:00

abstract：:Between 1978 and 1985, the number of active internists in the United States increased from 64,000 to 91,000, and by 1998 the number will have increased to 141,000. This growth represents an increase of 121% for a 20-year period, during which time the population of the United States is expected to increase only 19%. Th...

journal_title：Annals of internal medicine

authors： Kletke PR,Schleiter MK,Tarlov AR

更新日期：1987-07-01 00:00:00

abstract：:Impairment of penicillin G excretion in renal failure may result in life-threatening, dose-related toxicity. We report a method for achieving a desired mean serum penicillin G concentration in patients with renal failure, with minimal risk of both undertreatment and drug toxicity. The method is based on the linear rel...

journal_title：Annals of internal medicine

authors： Bryan CS,Stone WJ

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:Nurse care management programs for patients with chronic illness have been shown to be safe and effective. OBJECTIVE:To determine whether a telephone-mediated nurse care management program for heart failure reduced the rate of rehospitalization for heart failure and for all causes over a 1-year period. DES...

journal_title：Annals of internal medicine

authors： DeBusk RF,Miller NH,Parker KM,Bandura A,Kraemer HC,Cher DJ,West JA,Fowler MB,Greenwald G

更新日期：2004-10-19 00:00:00

abstract：BACKGROUND:The sequelae during the first two decades after acute hepatitis C virus (HCV) infection have been well studied, but the outcome thereafter is unknown. OBJECTIVE:To conduct an extended study of the natural history of HCV infection by using archived serum specimens originally collected between 1948 and 1954. ...

journal_title：Annals of internal medicine

authors： Seeff LB,Miller RN,Rabkin CS,Buskell-Bales Z,Straley-Eason KD,Smoak BL,Johnson LD,Lee SR,Kaplan EL

更新日期：2000-01-18 00:00:00

abstract：:Twenty-one juvenile-onset diabetic patients with azotemic nephropathy underwent coronary angiography and left ventriculography before renal transplantation or chronic hemodialysis. Two-year survival of 12 patients with no coronary artery disease (group A) was 88% compared to 22% for nine patients with coronary artery ...

journal_title：Annals of internal medicine

authors： Weinrauch LA,D'elia JA,Healy RW,Gleason RE,Takacs FJ,Libertino JA,Leland OS

更新日期：1978-03-01 00:00:00