Acquired intolerance to organic solvents and results of vestibular testing.

Abstract:

:Among 160 consecutive patients referred to the Clinic of Occupational Medicine, Rigshospitalet, for symptoms connected with exposure to organic solvents, 20 exhibited symptoms of acquired intolerance to minor amounts of organic solvents. Later, an additional 30 consecutive patients with symptoms of acquired intolerance were included, yielding a total of 43 men and 7 women. The characteristics of the clinical syndrome described are complaints of dizziness, nausea, and weakness after exposure to minimal solvent vapor concentrations. After having tolerated long-term occupational exposure to moderate or high air concentrations of various organic solvents, the patients became intolerant within a short period of time. Since dizziness was a frequent complaint, we tried to obtain a measure of the patients' complaints using vestibular tests. As a diagnostic test the combined vestibular tests had a sensitivity of 0.55 and a specificity of 0.87. No differences between patients with and without intolerance could be detected by the vestibular tests used. We conclude that acquired intolerance to organic solvents is a new but characteristic and easily recognizable syndrome, often with severe consequences for the patient's working ability.

journal_name

Am J Ind Med

authors

Gyntelberg F,Vesterhauge S,Fog P,Isager H,Zillstorff K

doi

10.1002/ajim.4700090408

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

363-70

issue

4

eissn

0271-3586

issn

1097-0274

journal_volume

9

pub_type

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