Abstract：
:The risk for Alzheimer's disease (AD) is influenced by both age and ApoE status. The present study addresses the associations of age and ApoE status on complex pathologic features in AD (n=81) including coexistent cerebrovascular disease (CVD), argyrophilic grain disease (AGD), and Lewy body disease (LBD). The frequency of coexistent cerebrovascular disease increased with increasing age. Age and ApoE status were differentially associated with atherosclerosis, lacunar infarctions, and microvascular pathology. Coexistent Lewy body pathology was negatively associated with age, dropping off abruptly after age 90. The presence of an ApoE epsilon4 allele was associated with an increased frequency of coexistent LBD. Logistic regression analyses demonstrated both dependent and independent effects of age and ApoE status on the presence of coexistent Lewy body pathology in AD. While the decreasing frequency of LBD in AD after age 90 could be partly accounted for by a lower probability of an ApoE epsilon4 allele, the independent association with age suggests either 1) a survival effect, 2) decreased incidence with advancing age, or 3) both.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Jicha GA,Parisi JE,Dickson DW,Cha RH,Johnson KA,Smith GE,Boeve BF,Petersen RC,Knopman DSdoi
10.1016/j.jns.2008.06.008subject
Has Abstractpub_date
2008-10-15 00:00:00pages
34-9issue
1-2eissn
0022-510Xissn
1878-5883pii
S0022-510X(08)00273-6journal_volume
273pub_type
杂志文章abstract：:To determine the prevalence and subtypes of dementia in southern Taiwan, a two-phase study consisting of a phase I screening survey using the Mini-Mental Status Examination (MMSE) and a phase II diagnostic examination using the CERAD neuropsychological battery and the neurobehavioral examination was conducted. Accordi...
journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
doi：10.1016/j.jns.2008.12.025
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
pub_type： 临床试验,杂志文章
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更新日期：1994-05-01 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：2002-08-15 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2003-05-15 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：2016-02-15 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章,评审
doi：10.1016/j.jns.2005.03.012
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abstract：:A sensitive enzyme immunoassay (EIA) micromethod is described which can measure levels of a 14 kDa human brain lectin (HBL) in the cerebrospinal fluid (CSF) of patients submitted to CSF examination. The assay is based on the use of a polyclonal antibody to HBL and the simultaneous application of biotinylated and unlab...
journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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