Abstract:
:Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) is a ligand-activated transcription factor with essential functions in the regulation of lipid catabolism, glucose homeostasis, and inflammation, which makes it a potentially relevant drug target for the treatment of major human diseases. In addition, there is strong evidence that PPARbeta/delta modulates oncogenic signaling pathways and tumor growth. Consistent with these observations, numerous reports have clearly documented a role for PPARbeta/delta in cell cycle control, differentiation, and apoptosis. However, the precise role of PPARbeta/delta in tumorigenesis and cell proliferation remains controversial. This review summarizes our current knowledge and proposes a model corroborating the discrepant data in this area of research.
journal_name
PPAR Resjournal_title
PPAR researchauthors
Müller R,Rieck M,Müller-Brüsselbach Sdoi
10.1155/2008/614852subject
Has Abstractpub_date
2008-01-01 00:00:00pages
614852eissn
1687-4757issn
1687-4765journal_volume
2008pub_type
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