Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis.

Abstract:

:The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Specifically, PPARG has been implicated in the regulation of processes concerning metabolism, inflammation, atherosclerosis, cell differentiation, and proliferation. Thus, a considerable amount of literature has emerged in the last ten years linking PPARG signalling with metabolic conditions such as obesity and diabetes, cardiovascular disease, and, more recently, cancer. This review paper, at crossroads of basic sciences, preclinical, and clinical data, intends to analyse the last research concerning PPARG signalling in obesity and cancer. Afterwards, possible links between four interrelated actors will be established: PPARG, the vitamin D/VDR system, obesity, and cancer, opening up the door to further investigation and new hypothesis in this fascinating area of research.

journal_name

PPAR Res

journal_title

PPAR research

authors

Bandera Merchan B,Tinahones FJ,Macías-González M

doi

10.1155/2016/2308249

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

2308249

eissn

1687-4757

issn

1687-4765

journal_volume

2016

pub_type

杂志文章,评审
  • PPAR Agonists and Cardiovascular Disease in Diabetes.

    abstract::Peroxisome proliferators activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostasis. To the extent that PPAR agonists improve diabetic dyslipidaemia and insulin resistance, these agents have been considered to reduce cardiovascular risk. Ho...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2008/245410

    authors: Calkin AC,Thomas MC

    更新日期:2008-01-01 00:00:00

  • PPAR-gamma Signaling Crosstalk in Mesenchymal Stem Cells.

    abstract::Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcriptional factors. Among other functions, PPAR-gamma acts as a key regulator of the adipogenesis. Since several cytokines (IL-1, TNF-alpha, TGF-beta) had been known to inhibit ad...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2010/341671

    authors: Takada I,Kouzmenko AP,Kato S

    更新日期:2010-01-01 00:00:00

  • The role of peroxisome proliferator-activated receptors in colorectal cancer.

    abstract::Colorectal cancer is one of the most common cancers in the world. Dietary fat intake is a major risk factor for colorectal cancer. Some nuclear hormone receptors play an important role in regulating nutrient metabolism and energy homeostasis. Among these receptors, special attention has been focused on the role of per...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2012/876418

    authors: Park JI,Kwak JY

    更新日期:2012-01-01 00:00:00

  • Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor γ Agonist In Vivo.

    abstract::Peroxisome proliferator-activated receptor γ (PPARγ) forms a heterodimeric DNA-binding complex with retinoid X receptors (RXRs). It has been reported that the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice. Therefore, it is suggested that the endogenous RXR ligand is involved in the PPARγ agoni...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2011/840194

    authors: Yamamoto A,Kakuta H,Miyachi H,Sugimoto Y

    更新日期:2011-01-01 00:00:00

  • Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance.

    abstract::Hyperhomocysteinemia, a risk factor for vascular disease, is associated with metabolic syndrome. Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling. We also studied oxidative stress and expression of PPARγ in the coronary arteriole as a poss...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2018/6738703

    authors: Huo Y,Wu X,Ding J,Geng Y,Qiao W,Ge A,Guo C,Lv J,Bao H,Fan W

    更新日期:2018-01-15 00:00:00

  • Nitrooleic Acid Attenuates Lipid Metabolic Disorders and Liver Steatosis in DOCA-Salt Hypertensive Mice.

    abstract::Nitrooleic acid (OA-NO2) is endogenous ligands for peroxisome proliferator-activated receptors. The present study was aimed at investigating the beneficial effects of OA-NO2 on the lipid metabolism and liver steatosis in deoxycorticosterone acetate- (DOCA-) salt induced hypertensive mice model. Male C57BL/6 mice were ...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2015/480348

    authors: Wang H,Sun J,Jia Z,Yang T,Xu L,Zhao B,Yu K,Wang R

    更新日期:2015-01-01 00:00:00

  • Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice.

    abstract::Aster glehni is well known for its therapeutic properties. This study was performed to investigate the effects of A. glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue....

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2017/3912567

    authors: Lee YJ,Jang YN,Han YM,Kim HM,Jeong JM,Son MJ,Jin CB,Kim HJ,Seo HS

    更新日期:2017-01-01 00:00:00

  • Downregulation of the proinflammatory state of circulating mononuclear cells by short-term treatment with pioglitazone in patients with type 2 diabetes mellitus and coronary artery disease.

    abstract::Background. This study was performed to investigate the influence of a short-term treatment with pioglitazone versus placebo on inflammatory activation of mononuclear cells (mRNA expression/protein secretion of inflammatory markers). Methods and Results. Sixty-three patients with well-controlled type 2 diabetes (52 ma...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2011/647017

    authors: Pfützner A,Weise A,Pfützner-Riehn E,Lübben G,Morcos M,Karagiannis E,Weber M,Forst T

    更新日期:2011-01-01 00:00:00

  • Homocysteine and Hypertension in Diabetes: Does PPARgamma Have a Regulatory Role?

    abstract::Dysfunction of macro- and microvessels is a major cause of morbidity and mortality in patients with cardio-renovascular diseases such as atherosclerosis, hypertension, and diabetes. Renal failure and impairment of renal function due to vasoconstriction of the glomerular arteriole in diabetic nephropathy leads to renal...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2010/806538

    authors: Sen U,Tyagi SC

    更新日期:2010-01-01 00:00:00

  • Phthalate-Induced Liver Protection against Deleterious Effects of the Th1 Response: A Potentially Serious Health Hazard.

    abstract::Infection with Mycobacterium tuberculosis (TB) induces pulmonary immunopathology mediated by classical Th1 type of acquired immunity with hepatic involvement in up to 80% of disseminated cases. Since PPAR agonists cause immune responses characterized by a decrease in the secretion of Th1 cytokines, we investigated the...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2007/49671

    authors: Badr MZ,Shnyra A,Zoubine M,Norkin M,Herndon B,Quinn T,Miranda RN,Cunningham ML,Molteni A

    更新日期:2007-01-01 00:00:00

  • Zebrafish as a Model to Study the Role of Peroxisome Proliferating-Activated Receptors in Adipogenesis and Obesity.

    abstract::The Peroxisome Proliferator-Activated Receptors (PPARs) PPARA and PPARD are regulators of lipid metabolism with important roles in energy release through lipid breakdown, while PPARG plays a key role in lipid storage and adipogenesis. The aim of this review is to describe the role of PPARs in lipid metabolism, adipoge...

    journal_title:PPAR research

    pub_type: 杂志文章,评审

    doi:10.1155/2015/358029

    authors: Den Broeder MJ,Kopylova VA,Kamminga LM,Legler J

    更新日期:2015-01-01 00:00:00

  • The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils.

    abstract::PPARγ agonists can either enhance or inhibit eosinophil migration, which is a sum of directional migration (chemotaxis) and random cell movement (chemokinesis). To date, the effects of PPAR agonists on chemokinesis have not been examined. This study investigates the effects of PPARα, δ, and γ agonists on eosinophil mi...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2012/235231

    authors: Smith SG,Imaoka H,Punia N,Irshad A,Janssen LL,Sehmi R,Gauvreau GM

    更新日期:2012-01-01 00:00:00

  • Inhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X ReceptorAlpha.

    abstract::It has been proposed that PPAR-dependent, accelerated catabolism of proinflammatory mediators may contribute to the fast resolution of inflammation. Because retinoid X receptors are obligate heterodimer partners of PPARs, we investigated the impact of deleting hepatocyte-specific RXRalpha on the antiedema effect of PP...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/PPAR/2006/96341

    authors: Wan YJ,Badr MZ

    更新日期:2006-01-01 00:00:00

  • Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARgamma Expression and Activation in Differentiating Mesenchymal Stem Cells.

    abstract::Protein farnesylation is required for the activation of multiple proteins involved in cell differentiation and function. In white adipose tissue protein, farnesylation has shown to be essential for the successful differentiation of preadipocytes into adipocytes. We hypothesize that protein farnesylation is required fo...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2007/81654

    authors: Rivas D,Akter R,Duque G

    更新日期:2007-01-01 00:00:00

  • Diet Modifies Pioglitazone's Influence on Hepatic PPARγ-Regulated Mitochondrial Gene Expression.

    abstract::Pioglitazone (Pio) is a thiazolidinedione (TZD) insulin-sensitizing drug whose effects result predominantly from its modulation of the transcriptional activity of peroxisome proliferator-activated-receptor-gamma (PPARγ). Pio is used to treat human insulin-resistant diabetes and also frequently considered for treatment...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2020/3817573

    authors: Kulkarni S,Huang J,Tycksen E,Cliften PF,Rudnick DA

    更新日期:2020-09-10 00:00:00

  • Peroxisome Proliferator-Activated Receptor Delta: A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle.

    abstract::The peroxisome proliferator-activated receptors (PPARs), which are ligand-inducible transcription factors expressed in a variety of tissues, have been shown to perform key roles in lipid homeostasis. In physiological situations such as fasting and physical exercise, one PPAR subtype, PPARdelta, triggers a transcriptio...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2008/172676

    authors: de Lange P,Lombardi A,Silvestri E,Goglia F,Lanni A,Moreno M

    更新日期:2008-01-01 00:00:00

  • Association of PPAR Alpha Intron 7 G/C, PPAR Gamma 2 Pro12Ala, and C161T Polymorphisms with Serum Fetuin-A Concentrations.

    abstract:BACKGROUND:Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism. AIMS:We investigated whether PPARα intron 7 G2468/C and PPARγ2 Pro12Ala and PPARγ exon 6 C161T polymorphisms are associated with serum fetuin-A concentrations. PATIENTS AND METHODS:The PPARα intron 7 G/C po...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2017/7636019

    authors: Márkus B,Vörös K,Supák D,Melczer Z,Cseh K,Kalabay L

    更新日期:2017-01-01 00:00:00

  • Pioglitazone Effect on Glioma Stem Cell Lines: Really a Promising Drug Therapy for Glioblastoma?

    abstract::Glioblastoma multiforme (GBM) represents one of the most frequent malignant brain tumors. Current therapies do not provide real solutions to this pathology. Their failure can be ascribed to a cell subpopulation with stem-like properties called glioma stem cells (GSCs). Therefore, new therapeutic strategies GSC-targete...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2016/7175067

    authors: Cilibrasi C,Butta V,Riva G,Bentivegna A

    更新日期:2016-01-01 00:00:00

  • Pparg may Promote Chemosensitivity of Hypopharyngeal Squamous Cell Carcinoma.

    abstract::The upregulation of peroxisome proliferator-activated receptor gamma (PPARG) has been shown to increase the chemosensitivity of several human cancers. This study is aimed at studying if PPARG sensitizes hypopharyngeal squamous cell carcinoma (HSCC) in chemotherapeutic treatments and at dissecting possible mechanisms o...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2020/6452182

    authors: Lian M,Chen J,Shen X,Hou L,Fang J

    更新日期:2020-04-22 00:00:00

  • PPARs Expression in Adult Mouse Neural Stem Cells: Modulation of PPARs during Astroglial Differentiaton of NSC.

    abstract::PPAR isotypes are involved in the regulation of cell proliferation, death, and differentiation, with different roles and mechanisms depending on the specific isotype and ligand and on the differentiated, undifferentiated, or transformed status of the cell. Differentiation stimuli are integrated by key transcription fa...

    journal_title:PPAR research

    pub_type: 杂志文章,收录出版

    doi:10.1155/2007/48242

    authors: Cimini A,Cristiano L,Benedetti E,D'Angelo B,Cerù MP

    更新日期:2007-01-01 00:00:00

  • Peroxisome proliferator activated receptor ligands as regulators of airway inflammation and remodelling in chronic lung disease.

    abstract::Inflammation is a major component in the pathology of chronic lung diseases, including asthma. Anti-inflammatory treatment with corticosteroids is not effective in all patients. Thus, new therapeutic options are required to control diverse cellular functions that are currently not optimally targeted by these drugs in ...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2007/14983

    authors: Ward JE,Tan X

    更新日期:2007-01-01 00:00:00

  • PPARgamma: The Portrait of a Target Ally to Cancer Chemopreventive Agents.

    abstract::Peroxisome proliferator-activated receptor-gamma (PPARgamma), one of three ligand-activated transcription factors named PPAR, has been identified as a molecular target for cancer chemopreventive agents. PPARgamma was initially understood as a regulator of adipocyte differentiation and glucose homeostasis while later o...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2008/436489

    authors: Sainis I,Vareli K,Karavasilis V,Briasoulis E

    更新日期:2008-01-01 00:00:00

  • 15-Deoxy-Δ(12,14)-prostaglandin J2 Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells.

    abstract::The cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) is a natural ligand of peroxisome proliferator-activated receptor gamma (PPAR-γ) and a potential mediator of apoptosis in cancer cells. In the present study, we evaluated the effect of 15d-PGJ2 in human thyroid papillary carcinoma cells (TP...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2016/4106297

    authors: Trindade-da-Silva CA,Reis CF,Vecchi L,Napimoga MH,Sperandio M,Matias Colombo BF,Alves PT,Ward LS,Ueira-Vieira C,Goulart LR

    更新日期:2016-01-01 00:00:00

  • Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARδ Regulation in Hyperlipidemic and Hypertensive Conditions.

    abstract::To investigate the effects of fimasartan on nonalcoholic fatty liver disease in hyperlipidemic and hypertensive conditions, the levels of biomarkers related to fatty acid metabolism were determined in HepG2 and differentiated 3T3-L1 cells treated by high fatty acid and liver and visceral fat tissue samples of spontane...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2017/8048720

    authors: Lee YJ,Jang YN,Han YM,Kim HM,Jeong JM,Seo HS

    更新日期:2017-01-01 00:00:00

  • The Role of PPARs in Placental Immunology: A Systematic Review of the Literature.

    abstract::Pregnancy is a state of immunotolerance, and pregnancy outcome is strongly linked to the correct activation and balancing of the maternal immune system. Besides abortion as possible result of improper early pregnancy development, other pregnancy associated conditions like preeclampsia (PE), intrauterine growth retarda...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2013/970276

    authors: Hutter S,Knabl J,Andergassen U,Jeschke U

    更新日期:2013-01-01 00:00:00

  • PPAR-α Agonist Fenofibrate Decreased Serum Irisin Levels in Type 2 Diabetes Patients with Hypertriglyceridemia.

    abstract::Irisin is related to insulin resistance and metabolic disorders. The physiologic effects of irisin are partially mediated through peroxisome proliferator-activated receptor-α (PPAR-α). We investigated the effect of fenofibrate, a PPAR-α agonist, on serum irisin in type 2 diabetes patients with hypertriglyceridemia. Th...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2015/924131

    authors: Feng X,Gao X,Jia Y,Zhang H,Pan Q,Yao Z,Yang N,Liu J,Xu Y,Wang G,Yang X

    更新日期:2015-01-01 00:00:00

  • The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis.

    abstract::PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been known as a hallmark o...

    journal_title:PPAR research

    pub_type: 杂志文章,评审

    doi:10.1155/2020/3608315

    authors: Du S,Wagner N,Wagner KD

    更新日期:2020-08-13 00:00:00

  • Therapeutic Potential of PPARγ Activation in Stroke.

    abstract::Stroke (focal cerebral ischemia) is a leading cause of death and disability among adult population. Many pathological events including inflammation and oxidative stress during the acute period contributes to the secondary neuronal death leading the neurological dysfunction after stroke. Transcriptional regulation of g...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2008/461981

    authors: Vemuganti R

    更新日期:2008-01-01 00:00:00

  • Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal Markers When Feeding Is Restricted to Two Daytime Hours.

    abstract::Restricted feeding (RF) during daytime is associated with anticipatory activity before feeding, marked hyperphagia after mealtime, adjustments in hepatic metabolism, and the expression of a food-entrained oscillator (FEO). 24 h rhythmicity of liver PPARα, β, and γ, peroxisomal markers (PMP70, AOX, and catalase), and f...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2011/261584

    authors: Rivera-Zavala JB,Báez-Ruiz A,Díaz-Muñoz M

    更新日期:2011-01-01 00:00:00

  • Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ.

    abstract::Cells can shift their metabolism between glycolysis and oxidative phosphorylation to enact their cell fate program in response to external signals. Widely distributed α1-adrenergic receptors (ARs) are physiologically stimulated during exercise, were reported to associate with the activating energetic AMPK pathway, and...

    journal_title:PPAR research

    pub_type: 杂志文章

    doi:10.1155/2020/3785137

    authors: Lee YJ,Kim HS,Seo HS,Na JO,Jang YN,Han YM,Kim HM

    更新日期:2020-02-01 00:00:00