Therapeutic Potential of PPARγ Activation in Stroke.

Abstract:

:Stroke (focal cerebral ischemia) is a leading cause of death and disability among adult population. Many pathological events including inflammation and oxidative stress during the acute period contributes to the secondary neuronal death leading the neurological dysfunction after stroke. Transcriptional regulation of genes that promote these pathophysiological mechanisms can be an effective strategy to minimize the poststroke neuronal death. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors known to be upstream to many inflammatory and antioxidant genes. The goal of this review is to discuss the therapeutic potential and putative mechanisms of neuroprotection following PPAR activation after stroke.

journal_name

PPAR Res

journal_title

PPAR research

authors

Vemuganti R

doi

10.1155/2008/461981

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

461981

eissn

1687-4757

issn

1687-4765

journal_volume

2008

pub_type

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