Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARδ Regulation in Hyperlipidemic and Hypertensive Conditions.

abstract：:Stroke (focal cerebral ischemia) is a leading cause of death and disability among adult population. Many pathological events including inflammation and oxidative stress during the acute period contributes to the secondary neuronal death leading the neurological dysfunction after stroke. Transcriptional regulation of g...

journal_title：PPAR research

authors： Vemuganti R

更新日期：2008-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) represents one of the most frequent malignant brain tumors. Current therapies do not provide real solutions to this pathology. Their failure can be ascribed to a cell subpopulation with stem-like properties called glioma stem cells (GSCs). Therefore, new therapeutic strategies GSC-targete...

journal_title：PPAR research

authors： Cilibrasi C,Butta V,Riva G,Bentivegna A

更新日期：2016-01-01 00:00:00

abstract：:Dysfunction of macro- and microvessels is a major cause of morbidity and mortality in patients with cardio-renovascular diseases such as atherosclerosis, hypertension, and diabetes. Renal failure and impairment of renal function due to vasoconstriction of the glomerular arteriole in diabetic nephropathy leads to renal...

journal_title：PPAR research

authors： Sen U,Tyagi SC

更新日期：2010-01-01 00:00:00

abstract：:INT131 (formerly T0903131, T131, AMG131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor gamma modulator (SPPARM) currently in Phase 2 clinical trials for treatment of type-2 diabetes mellitus (T2DM). This new chemical entity represents a second generation SPPARM approach d...

journal_title：PPAR research

authors： Higgins LS,Mantzoros CS

更新日期：2008-01-01 00:00:00

abstract：:Cells can shift their metabolism between glycolysis and oxidative phosphorylation to enact their cell fate program in response to external signals. Widely distributed α1-adrenergic receptors (ARs) are physiologically stimulated during exercise, were reported to associate with the activating energetic AMPK pathway, and...

journal_title：PPAR research

authors： Lee YJ,Kim HS,Seo HS,Na JO,Jang YN,Han YM,Kim HM

更新日期：2020-02-01 00:00:00

abstract：:Protein farnesylation is required for the activation of multiple proteins involved in cell differentiation and function. In white adipose tissue protein, farnesylation has shown to be essential for the successful differentiation of preadipocytes into adipocytes. We hypothesize that protein farnesylation is required fo...

journal_title：PPAR research

authors： Rivas D,Akter R,Duque G

更新日期：2007-01-01 00:00:00

abstract：:Pioglitazone (Pio) is a thiazolidinedione (TZD) insulin-sensitizing drug whose effects result predominantly from its modulation of the transcriptional activity of peroxisome proliferator-activated-receptor-gamma (PPARγ). Pio is used to treat human insulin-resistant diabetes and also frequently considered for treatment...

journal_title：PPAR research

authors： Kulkarni S,Huang J,Tycksen E,Cliften PF,Rudnick DA

更新日期：2020-09-10 00:00:00

abstract：:The past decade of PPARγ research has dramatically improved our understanding of the structural and mechanistic bases for the diverging physiological effects of different classes of PPARγ ligands. The discoveries that lie at the heart of these developments have enabled the design of a new class of PPARγ ligands, capab...

journal_title：PPAR research

authors： Kaupang Å,Hansen TV

更新日期：2020-07-01 00:00:00

abstract：:Pregnancy is a state of immunotolerance, and pregnancy outcome is strongly linked to the correct activation and balancing of the maternal immune system. Besides abortion as possible result of improper early pregnancy development, other pregnancy associated conditions like preeclampsia (PE), intrauterine growth retarda...

journal_title：PPAR research

authors： Hutter S,Knabl J,Andergassen U,Jeschke U

更新日期：2013-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Their discovery in the 1990s provided insights into the cellular mechanisms involved in the control of energy homeostasis, the regulation of cell differentiation, prolif...

journal_title：PPAR research

authors： Han SW,Roman J

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism. AIMS:We investigated whether PPARα intron 7 G2468/C and PPARγ2 Pro12Ala and PPARγ exon 6 C161T polymorphisms are associated with serum fetuin-A concentrations. PATIENTS AND METHODS:The PPARα intron 7 G/C po...

journal_title：PPAR research

authors： Márkus B,Vörös K,Supák D,Melczer Z,Cseh K,Kalabay L

更新日期：2017-01-01 00:00:00

abstract：:Pancreatic cancer is a devastating disease in which current therapies are inadequate. Separate lines of research have identified the 5-lipoxygenase/leukotriene B(4) receptor pathway and the PPARgamma pathway as potential targets for prevention or treatment of this disease. LY293111 was originally designed as a potent ...

journal_title：PPAR research

authors： Adrian TE,Hennig R,Friess H,Ding X

更新日期：2008-01-01 00:00:00

abstract：:Hyperhomocysteinemia, a risk factor for vascular disease, is associated with metabolic syndrome. Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling. We also studied oxidative stress and expression of PPARγ in the coronary arteriole as a poss...

journal_title：PPAR research

authors： Huo Y,Wu X,Ding J,Geng Y,Qiao W,Ge A,Guo C,Lv J,Bao H,Fan W

更新日期：2018-01-15 00:00:00

abstract：:Background. This study was performed to investigate the influence of a short-term treatment with pioglitazone versus placebo on inflammatory activation of mononuclear cells (mRNA expression/protein secretion of inflammatory markers). Methods and Results. Sixty-three patients with well-controlled type 2 diabetes (52 ma...

journal_title：PPAR research

authors： Pfützner A,Weise A,Pfützner-Riehn E,Lübben G,Morcos M,Karagiannis E,Weber M,Forst T

更新日期：2011-01-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist rosiglitazone inhibits NF-κB expression and endogenous neural stem cell differentiation into neurons and reduces the inflammatory cascade after spinal cord injury (SCI). The aim of this study was to explore the mechanisms underlying rosiglitazone-me...

journal_title：PPAR research

authors： Meng QQ,Lei W,Chen H,Feng ZC,Hu LQ,Zhang XL,Li S

更新日期：2018-06-21 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma), one of three ligand-activated transcription factors named PPAR, has been identified as a molecular target for cancer chemopreventive agents. PPARgamma was initially understood as a regulator of adipocyte differentiation and glucose homeostasis while later o...

journal_title：PPAR research

authors： Sainis I,Vareli K,Karavasilis V,Briasoulis E

更新日期：2008-01-01 00:00:00

abstract：:Aster glehni is well known for its therapeutic properties. This study was performed to investigate the effects of A. glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue....

journal_title：PPAR research

authors： Lee YJ,Jang YN,Han YM,Kim HM,Jeong JM,Son MJ,Jin CB,Kim HJ,Seo HS

更新日期：2017-01-01 00:00:00

abstract：:The cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) is a natural ligand of peroxisome proliferator-activated receptor gamma (PPAR-γ) and a potential mediator of apoptosis in cancer cells. In the present study, we evaluated the effect of 15d-PGJ2 in human thyroid papillary carcinoma cells (TP...

journal_title：PPAR research

authors： Trindade-da-Silva CA,Reis CF,Vecchi L,Napimoga MH,Sperandio M,Matias Colombo BF,Alves PT,Ward LS,Ueira-Vieira C,Goulart LR

更新日期：2016-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) forms a heterodimeric DNA-binding complex with retinoid X receptors (RXRs). It has been reported that the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice. Therefore, it is suggested that the endogenous RXR ligand is involved in the PPARγ agoni...

journal_title：PPAR research

authors： Yamamoto A,Kakuta H,Miyachi H,Sugimoto Y

更新日期：2011-01-01 00:00:00

abstract：:Acute attacks of multiple sclerosis (MS) are most commonly treated with glucocorticoids, which can provide life-saving albeit only temporary symptomatic relief. The mechanism of action (MOA) is now known to involve induction of indoleamine 2,3-dioxygenase (IDO) and interleukin-10 (IL-10), where IL-10 requires subseque...

journal_title：PPAR research

authors： Penberthy WT

更新日期：2009-01-01 00:00:00

abstract：:It has been proposed that PPAR-dependent, accelerated catabolism of proinflammatory mediators may contribute to the fast resolution of inflammation. Because retinoid X receptors are obligate heterodimer partners of PPARs, we investigated the impact of deleting hepatocyte-specific RXRalpha on the antiedema effect of PP...

journal_title：PPAR research

authors： Wan YJ,Badr MZ

更新日期：2006-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR alpha, beta/delta and gamma) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system. Moreover, PPARs have various extra metabolic roles, in circadian rhythms, inflammation and oxidative st...

journal_title：PPAR research

authors： Lecarpentier Y,Claes V,Hébert JL

更新日期：2010-01-01 00:00:00

abstract：:Irisin is related to insulin resistance and metabolic disorders. The physiologic effects of irisin are partially mediated through peroxisome proliferator-activated receptor-α (PPAR-α). We investigated the effect of fenofibrate, a PPAR-α agonist, on serum irisin in type 2 diabetes patients with hypertriglyceridemia. Th...

journal_title：PPAR research

authors： Feng X,Gao X,Jia Y,Zhang H,Pan Q,Yao Z,Yang N,Liu J,Xu Y,Wang G,Yang X

更新日期：2015-01-01 00:00:00

abstract：:Infection with Mycobacterium tuberculosis (TB) induces pulmonary immunopathology mediated by classical Th1 type of acquired immunity with hepatic involvement in up to 80% of disseminated cases. Since PPAR agonists cause immune responses characterized by a decrease in the secretion of Th1 cytokines, we investigated the...

journal_title：PPAR research

authors： Badr MZ,Shnyra A,Zoubine M,Norkin M,Herndon B,Quinn T,Miranda RN,Cunningham ML,Molteni A

更新日期：2007-01-01 00:00:00

abstract：:Peroxisome proliferators activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostasis. To the extent that PPAR agonists improve diabetic dyslipidaemia and insulin resistance, these agents have been considered to reduce cardiovascular risk. Ho...

journal_title：PPAR research

authors： Calkin AC,Thomas MC

更新日期：2008-01-01 00:00:00

abstract：:PPAR isotypes are involved in the regulation of cell proliferation, death, and differentiation, with different roles and mechanisms depending on the specific isotype and ligand and on the differentiated, undifferentiated, or transformed status of the cell. Differentiation stimuli are integrated by key transcription fa...

journal_title：PPAR research

authors： Cimini A,Cristiano L,Benedetti E,D'Angelo B,Cerù MP

更新日期：2007-01-01 00:00:00

abstract：:Dendritic cells (DCs) can regulate all elements of the immune system, and therefore are an ideal target for vaccination. During the last two decades, as a result of extensive research, DCs became the primary target of antitumor vaccination as well. A critical issue of antitumor vaccination is the phenotype of the dend...

journal_title：PPAR research

authors： Gyöngyösi A,Nagy L

更新日期：2008-01-01 00:00:00

abstract：:While TOFA (acetyl CoA carboxylase inhibitor) and C75 (fatty acid synthase inhibitor) prevent lipid accumulation by inhibiting fatty acid synthesis, the mechanism of action is not simply accounted for by inhibition of the enzymes alone. Liver fatty acid binding protein (L-FABP), a mediator of long chain fatty acid sig...

journal_title：PPAR research

authors： Huang H,McIntosh AL,Martin GG,Petrescu AD,Landrock KK,Landrock D,Kier AB,Schroeder F

更新日期：2013-01-01 00:00:00

abstract：:Foxp3(+) regulatory T cells (Tregs) play a critical role in maintaining immune self-tolerance. Reduced number and activity of Tregs are usually found in autoimmune and inflammatory diseases, and enhancing the differentiation of Tregs may be a promising therapeutic strategy. Some reports suggested an anti-inflammatory ...

journal_title：PPAR research

authors： Zhou Z,Liang Y,Gao Y,Kong W,Feng J,Wang X

更新日期：2012-01-01 00:00:00

abstract：:PPARγ agonists can either enhance or inhibit eosinophil migration, which is a sum of directional migration (chemotaxis) and random cell movement (chemokinesis). To date, the effects of PPAR agonists on chemokinesis have not been examined. This study investigates the effects of PPARα, δ, and γ agonists on eosinophil mi...

journal_title：PPAR research

authors： Smith SG,Imaoka H,Punia N,Irshad A,Janssen LL,Sehmi R,Gauvreau GM

更新日期：2012-01-01 00:00:00