15-Deoxy-Δ(12,14)-prostaglandin J2 Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells.

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma), one of three ligand-activated transcription factors named PPAR, has been identified as a molecular target for cancer chemopreventive agents. PPARgamma was initially understood as a regulator of adipocyte differentiation and glucose homeostasis while later o...

journal_title：PPAR research

authors： Sainis I,Vareli K,Karavasilis V,Briasoulis E

更新日期：2008-01-01 00:00:00

abstract：:Background. This study was performed to investigate the influence of a short-term treatment with pioglitazone versus placebo on inflammatory activation of mononuclear cells (mRNA expression/protein secretion of inflammatory markers). Methods and Results. Sixty-three patients with well-controlled type 2 diabetes (52 ma...

journal_title：PPAR research

authors： Pfützner A,Weise A,Pfützner-Riehn E,Lübben G,Morcos M,Karagiannis E,Weber M,Forst T

更新日期：2011-01-01 00:00:00

abstract：:Stroke (focal cerebral ischemia) is a leading cause of death and disability among adult population. Many pathological events including inflammation and oxidative stress during the acute period contributes to the secondary neuronal death leading the neurological dysfunction after stroke. Transcriptional regulation of g...

journal_title：PPAR research

authors： Vemuganti R

更新日期：2008-01-01 00:00:00

abstract：:Peroxisome proliferators activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostasis. To the extent that PPAR agonists improve diabetic dyslipidaemia and insulin resistance, these agents have been considered to reduce cardiovascular risk. Ho...

journal_title：PPAR research

authors： Calkin AC,Thomas MC

更新日期：2008-01-01 00:00:00

abstract：:Aster glehni is well known for its therapeutic properties. This study was performed to investigate the effects of A. glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue....

journal_title：PPAR research

authors： Lee YJ,Jang YN,Han YM,Kim HM,Jeong JM,Son MJ,Jin CB,Kim HJ,Seo HS

更新日期：2017-01-01 00:00:00

abstract：:Colorectal cancer is one of the most common cancers in the world. Dietary fat intake is a major risk factor for colorectal cancer. Some nuclear hormone receptors play an important role in regulating nutrient metabolism and energy homeostasis. Among these receptors, special attention has been focused on the role of per...

journal_title：PPAR research

authors： Park JI,Kwak JY

更新日期：2012-01-01 00:00:00

abstract：:Irisin is related to insulin resistance and metabolic disorders. The physiologic effects of irisin are partially mediated through peroxisome proliferator-activated receptor-α (PPAR-α). We investigated the effect of fenofibrate, a PPAR-α agonist, on serum irisin in type 2 diabetes patients with hypertriglyceridemia. Th...

journal_title：PPAR research

authors： Feng X,Gao X,Jia Y,Zhang H,Pan Q,Yao Z,Yang N,Liu J,Xu Y,Wang G,Yang X

更新日期：2015-01-01 00:00:00

abstract：:Dendritic cells (DCs) can regulate all elements of the immune system, and therefore are an ideal target for vaccination. During the last two decades, as a result of extensive research, DCs became the primary target of antitumor vaccination as well. A critical issue of antitumor vaccination is the phenotype of the dend...

journal_title：PPAR research

authors： Gyöngyösi A,Nagy L

更新日期：2008-01-01 00:00:00

abstract：:The peroxisome proliferator-activated receptors (PPARs), which are ligand-inducible transcription factors expressed in a variety of tissues, have been shown to perform key roles in lipid homeostasis. In physiological situations such as fasting and physical exercise, one PPAR subtype, PPARdelta, triggers a transcriptio...

journal_title：PPAR research

authors： de Lange P,Lombardi A,Silvestri E,Goglia F,Lanni A,Moreno M

更新日期：2008-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) forms a heterodimeric DNA-binding complex with retinoid X receptors (RXRs). It has been reported that the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice. Therefore, it is suggested that the endogenous RXR ligand is involved in the PPARγ agoni...

journal_title：PPAR research

authors： Yamamoto A,Kakuta H,Miyachi H,Sugimoto Y

更新日期：2011-01-01 00:00:00

abstract：:Pioglitazone (Pio) is a thiazolidinedione (TZD) insulin-sensitizing drug whose effects result predominantly from its modulation of the transcriptional activity of peroxisome proliferator-activated-receptor-gamma (PPARγ). Pio is used to treat human insulin-resistant diabetes and also frequently considered for treatment...

journal_title：PPAR research

authors： Kulkarni S,Huang J,Tycksen E,Cliften PF,Rudnick DA

更新日期：2020-09-10 00:00:00

abstract：:Hyperhomocysteinemia, a risk factor for vascular disease, is associated with metabolic syndrome. Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling. We also studied oxidative stress and expression of PPARγ in the coronary arteriole as a poss...

journal_title：PPAR research

authors： Huo Y,Wu X,Ding J,Geng Y,Qiao W,Ge A,Guo C,Lv J,Bao H,Fan W

更新日期：2018-01-15 00:00:00

abstract：:Protein farnesylation is required for the activation of multiple proteins involved in cell differentiation and function. In white adipose tissue protein, farnesylation has shown to be essential for the successful differentiation of preadipocytes into adipocytes. We hypothesize that protein farnesylation is required fo...

journal_title：PPAR research

authors： Rivas D,Akter R,Duque G

更新日期：2007-01-01 00:00:00

abstract：:Infection with Mycobacterium tuberculosis (TB) induces pulmonary immunopathology mediated by classical Th1 type of acquired immunity with hepatic involvement in up to 80% of disseminated cases. Since PPAR agonists cause immune responses characterized by a decrease in the secretion of Th1 cytokines, we investigated the...

journal_title：PPAR research

authors： Badr MZ,Shnyra A,Zoubine M,Norkin M,Herndon B,Quinn T,Miranda RN,Cunningham ML,Molteni A

更新日期：2007-01-01 00:00:00

abstract：:Foxp3(+) regulatory T cells (Tregs) play a critical role in maintaining immune self-tolerance. Reduced number and activity of Tregs are usually found in autoimmune and inflammatory diseases, and enhancing the differentiation of Tregs may be a promising therapeutic strategy. Some reports suggested an anti-inflammatory ...

journal_title：PPAR research

authors： Zhou Z,Liang Y,Gao Y,Kong W,Feng J,Wang X

更新日期：2012-01-01 00:00:00

abstract：:Restricted feeding (RF) during daytime is associated with anticipatory activity before feeding, marked hyperphagia after mealtime, adjustments in hepatic metabolism, and the expression of a food-entrained oscillator (FEO). 24 h rhythmicity of liver PPARα, β, and γ, peroxisomal markers (PMP70, AOX, and catalase), and f...

journal_title：PPAR research

authors： Rivera-Zavala JB,Báez-Ruiz A,Díaz-Muñoz M

更新日期：2011-01-01 00:00:00

abstract：:PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been known as a hallmark o...

journal_title：PPAR research

authors： Du S,Wagner N,Wagner KD

更新日期：2020-08-13 00:00:00

abstract：:Improvements in our understanding of the functions of the nuclear receptor peroxisome proliferator-activated receptor (PPAR) subtypes as pleiotropic regulators of biological responses, including lipid, lipoprotein, glucose homeostasis, inflammation, differentiation and proliferation of various cancer cells, and memory...

journal_title：PPAR research

authors： Miyachi H,Hashimoto Y

更新日期：2008-01-01 00:00:00

abstract：:The past decade of PPARγ research has dramatically improved our understanding of the structural and mechanistic bases for the diverging physiological effects of different classes of PPARγ ligands. The discoveries that lie at the heart of these developments have enabled the design of a new class of PPARγ ligands, capab...

journal_title：PPAR research

authors： Kaupang Å,Hansen TV

更新日期：2020-07-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of the women of reproductive age. Familial clustering of PCOS has been consistently reported suggesting that genetic factors play a role in the development of the syndrome although PCOS cases do not exhibit a clear pattern of Mendelian inheritance....

journal_title：PPAR research

authors： Unluturk U,Harmanci A,Kocaefe C,Yildiz BO

更新日期：2007-01-01 00:00:00

abstract：:While TOFA (acetyl CoA carboxylase inhibitor) and C75 (fatty acid synthase inhibitor) prevent lipid accumulation by inhibiting fatty acid synthesis, the mechanism of action is not simply accounted for by inhibition of the enzymes alone. Liver fatty acid binding protein (L-FABP), a mediator of long chain fatty acid sig...

journal_title：PPAR research

authors： Huang H,McIntosh AL,Martin GG,Petrescu AD,Landrock KK,Landrock D,Kier AB,Schroeder F

更新日期：2013-01-01 00:00:00

abstract：:PPAR isotypes are involved in the regulation of cell proliferation, death, and differentiation, with different roles and mechanisms depending on the specific isotype and ligand and on the differentiated, undifferentiated, or transformed status of the cell. Differentiation stimuli are integrated by key transcription fa...

journal_title：PPAR research

authors： Cimini A,Cristiano L,Benedetti E,D'Angelo B,Cerù MP

更新日期：2007-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) represents one of the most frequent malignant brain tumors. Current therapies do not provide real solutions to this pathology. Their failure can be ascribed to a cell subpopulation with stem-like properties called glioma stem cells (GSCs). Therefore, new therapeutic strategies GSC-targete...

journal_title：PPAR research

authors： Cilibrasi C,Butta V,Riva G,Bentivegna A

更新日期：2016-01-01 00:00:00

abstract：:Cells can shift their metabolism between glycolysis and oxidative phosphorylation to enact their cell fate program in response to external signals. Widely distributed α1-adrenergic receptors (ARs) are physiologically stimulated during exercise, were reported to associate with the activating energetic AMPK pathway, and...

journal_title：PPAR research

authors： Lee YJ,Kim HS,Seo HS,Na JO,Jang YN,Han YM,Kim HM

更新日期：2020-02-01 00:00:00

abstract：:The Peroxisome Proliferator-Activated Receptors (PPARs) PPARA and PPARD are regulators of lipid metabolism with important roles in energy release through lipid breakdown, while PPARG plays a key role in lipid storage and adipogenesis. The aim of this review is to describe the role of PPARs in lipid metabolism, adipoge...

journal_title：PPAR research

authors： Den Broeder MJ,Kopylova VA,Kamminga LM,Legler J

更新日期：2015-01-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is a ubiquitous nuclear DNA-binding protein whose function is dependent on its cellular location. Extracellular HMGB1 is regarded as a delayed mediator of proinflammatory cytokines for initiating and amplifying inflammatory responses, whereas nuclear HMGB1 has been found to prevent ca...

journal_title：PPAR research

authors： Jia Z,Xue R,Liu G,Li L,Yang J,Pi G,Ma S,Kan Q

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism. AIMS:We investigated whether PPARα intron 7 G2468/C and PPARγ2 Pro12Ala and PPARγ exon 6 C161T polymorphisms are associated with serum fetuin-A concentrations. PATIENTS AND METHODS:The PPARα intron 7 G/C po...

journal_title：PPAR research

authors： Márkus B,Vörös K,Supák D,Melczer Z,Cseh K,Kalabay L

更新日期：2017-01-01 00:00:00

abstract：:During pregnancy crucial anatomic, physiologic, and metabolic changes challenge the mother and the fetus. The placenta is a remarkable organ that allows the mother and the fetus to adapt to the new metabolic, immunologic, and angiogenic environment imposed by gestation. One of the physiologic systems that appears to h...

journal_title：PPAR research

authors： Wieser F,Waite L,Depoix C,Taylor RN

更新日期：2008-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) activation decreased serum testosterone (T) in women with hyperthecosis and/or polycystic ovary syndrome and reduced the conversion of androgens to estradiol (E2) in female rats. This implies modulation of female sex steroid hormones by PPARγ. It is not clear if...

journal_title：PPAR research

authors： Mansour M,Coleman E,Dennis J,Akingbemi B,Schwartz D,Braden T,Judd R,Plaisance E,Stewart LK,Morrison E

更新日期：2009-01-01 00:00:00

abstract：:To investigate the effects of fimasartan on nonalcoholic fatty liver disease in hyperlipidemic and hypertensive conditions, the levels of biomarkers related to fatty acid metabolism were determined in HepG2 and differentiated 3T3-L1 cells treated by high fatty acid and liver and visceral fat tissue samples of spontane...

journal_title：PPAR research

authors： Lee YJ,Jang YN,Han YM,Kim HM,Jeong JM,Seo HS

更新日期：2017-01-01 00:00:00