Combined Rosiglitazone and Forskolin Have Neuroprotective Effects in SD Rats after Spinal Cord Injury.

abstract：:Colorectal cancer is one of the most common cancers in the world. Dietary fat intake is a major risk factor for colorectal cancer. Some nuclear hormone receptors play an important role in regulating nutrient metabolism and energy homeostasis. Among these receptors, special attention has been focused on the role of per...

journal_title：PPAR research

authors： Park JI,Kwak JY

更新日期：2012-01-01 00:00:00

abstract：:PPAR isotypes are involved in the regulation of cell proliferation, death, and differentiation, with different roles and mechanisms depending on the specific isotype and ligand and on the differentiated, undifferentiated, or transformed status of the cell. Differentiation stimuli are integrated by key transcription fa...

journal_title：PPAR research

authors： Cimini A,Cristiano L,Benedetti E,D'Angelo B,Cerù MP

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism. AIMS:We investigated whether PPARα intron 7 G2468/C and PPARγ2 Pro12Ala and PPARγ exon 6 C161T polymorphisms are associated with serum fetuin-A concentrations. PATIENTS AND METHODS:The PPARα intron 7 G/C po...

journal_title：PPAR research

authors： Márkus B,Vörös K,Supák D,Melczer Z,Cseh K,Kalabay L

更新日期：2017-01-01 00:00:00

abstract：:The upregulation of peroxisome proliferator-activated receptor gamma (PPARG) has been shown to increase the chemosensitivity of several human cancers. This study is aimed at studying if PPARG sensitizes hypopharyngeal squamous cell carcinoma (HSCC) in chemotherapeutic treatments and at dissecting possible mechanisms o...

journal_title：PPAR research

authors： Lian M,Chen J,Shen X,Hou L,Fang J

更新日期：2020-04-22 00:00:00

abstract：:Acute attacks of multiple sclerosis (MS) are most commonly treated with glucocorticoids, which can provide life-saving albeit only temporary symptomatic relief. The mechanism of action (MOA) is now known to involve induction of indoleamine 2,3-dioxygenase (IDO) and interleukin-10 (IL-10), where IL-10 requires subseque...

journal_title：PPAR research

authors： Penberthy WT

更新日期：2009-01-01 00:00:00

abstract：:Inflammation is a major component in the pathology of chronic lung diseases, including asthma. Anti-inflammatory treatment with corticosteroids is not effective in all patients. Thus, new therapeutic options are required to control diverse cellular functions that are currently not optimally targeted by these drugs in ...

journal_title：PPAR research

authors： Ward JE,Tan X

更新日期：2007-01-01 00:00:00

abstract：:Nitrooleic acid (OA-NO2) is endogenous ligands for peroxisome proliferator-activated receptors. The present study was aimed at investigating the beneficial effects of OA-NO2 on the lipid metabolism and liver steatosis in deoxycorticosterone acetate- (DOCA-) salt induced hypertensive mice model. Male C57BL/6 mice were ...

journal_title：PPAR research

authors： Wang H,Sun J,Jia Z,Yang T,Xu L,Zhao B,Yu K,Wang R

更新日期：2015-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) forms a heterodimeric DNA-binding complex with retinoid X receptors (RXRs). It has been reported that the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice. Therefore, it is suggested that the endogenous RXR ligand is involved in the PPARγ agoni...

journal_title：PPAR research

authors： Yamamoto A,Kakuta H,Miyachi H,Sugimoto Y

更新日期：2011-01-01 00:00:00

abstract：:INT131 (formerly T0903131, T131, AMG131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor gamma modulator (SPPARM) currently in Phase 2 clinical trials for treatment of type-2 diabetes mellitus (T2DM). This new chemical entity represents a second generation SPPARM approach d...

journal_title：PPAR research

authors： Higgins LS,Mantzoros CS

更新日期：2008-01-01 00:00:00

abstract：:The cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) is a natural ligand of peroxisome proliferator-activated receptor gamma (PPAR-γ) and a potential mediator of apoptosis in cancer cells. In the present study, we evaluated the effect of 15d-PGJ2 in human thyroid papillary carcinoma cells (TP...

journal_title：PPAR research

authors： Trindade-da-Silva CA,Reis CF,Vecchi L,Napimoga MH,Sperandio M,Matias Colombo BF,Alves PT,Ward LS,Ueira-Vieira C,Goulart LR

更新日期：2016-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcriptional factors. Among other functions, PPAR-gamma acts as a key regulator of the adipogenesis. Since several cytokines (IL-1, TNF-alpha, TGF-beta) had been known to inhibit ad...

journal_title：PPAR research

authors： Takada I,Kouzmenko AP,Kato S

更新日期：2010-01-01 00:00:00

abstract：:To investigate the effects of fimasartan on nonalcoholic fatty liver disease in hyperlipidemic and hypertensive conditions, the levels of biomarkers related to fatty acid metabolism were determined in HepG2 and differentiated 3T3-L1 cells treated by high fatty acid and liver and visceral fat tissue samples of spontane...

journal_title：PPAR research

authors： Lee YJ,Jang YN,Han YM,Kim HM,Jeong JM,Seo HS

更新日期：2017-01-01 00:00:00

abstract：:It has been proposed that PPAR-dependent, accelerated catabolism of proinflammatory mediators may contribute to the fast resolution of inflammation. Because retinoid X receptors are obligate heterodimer partners of PPARs, we investigated the impact of deleting hepatocyte-specific RXRalpha on the antiedema effect of PP...

journal_title：PPAR research

authors： Wan YJ,Badr MZ

更新日期：2006-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Their discovery in the 1990s provided insights into the cellular mechanisms involved in the control of energy homeostasis, the regulation of cell differentiation, prolif...

journal_title：PPAR research

authors： Han SW,Roman J

更新日期：2008-01-01 00:00:00

abstract：:Irisin is related to insulin resistance and metabolic disorders. The physiologic effects of irisin are partially mediated through peroxisome proliferator-activated receptor-α (PPAR-α). We investigated the effect of fenofibrate, a PPAR-α agonist, on serum irisin in type 2 diabetes patients with hypertriglyceridemia. Th...

journal_title：PPAR research

authors： Feng X,Gao X,Jia Y,Zhang H,Pan Q,Yao Z,Yang N,Liu J,Xu Y,Wang G,Yang X

更新日期：2015-01-01 00:00:00

abstract：:The past decade of PPARγ research has dramatically improved our understanding of the structural and mechanistic bases for the diverging physiological effects of different classes of PPARγ ligands. The discoveries that lie at the heart of these developments have enabled the design of a new class of PPARγ ligands, capab...

journal_title：PPAR research

authors： Kaupang Å,Hansen TV

更新日期：2020-07-01 00:00:00

abstract：:Restricted feeding (RF) during daytime is associated with anticipatory activity before feeding, marked hyperphagia after mealtime, adjustments in hepatic metabolism, and the expression of a food-entrained oscillator (FEO). 24 h rhythmicity of liver PPARα, β, and γ, peroxisomal markers (PMP70, AOX, and catalase), and f...

journal_title：PPAR research

authors： Rivera-Zavala JB,Báez-Ruiz A,Díaz-Muñoz M

更新日期：2011-01-01 00:00:00

abstract：:The Peroxisome Proliferator-Activated Receptors (PPARs) PPARA and PPARD are regulators of lipid metabolism with important roles in energy release through lipid breakdown, while PPARG plays a key role in lipid storage and adipogenesis. The aim of this review is to describe the role of PPARs in lipid metabolism, adipoge...

journal_title：PPAR research

authors： Den Broeder MJ,Kopylova VA,Kamminga LM,Legler J

更新日期：2015-01-01 00:00:00

abstract：:Aster glehni is well known for its therapeutic properties. This study was performed to investigate the effects of A. glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue....

journal_title：PPAR research

authors： Lee YJ,Jang YN,Han YM,Kim HM,Jeong JM,Son MJ,Jin CB,Kim HJ,Seo HS

更新日期：2017-01-01 00:00:00

abstract：:Pioglitazone (Pio) is a thiazolidinedione (TZD) insulin-sensitizing drug whose effects result predominantly from its modulation of the transcriptional activity of peroxisome proliferator-activated-receptor-gamma (PPARγ). Pio is used to treat human insulin-resistant diabetes and also frequently considered for treatment...

journal_title：PPAR research

authors： Kulkarni S,Huang J,Tycksen E,Cliften PF,Rudnick DA

更新日期：2020-09-10 00:00:00

abstract：:Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) is a ligand-activated transcription factor with essential functions in the regulation of lipid catabolism, glucose homeostasis, and inflammation, which makes it a potentially relevant drug target for the treatment of major human diseases. In additi...

journal_title：PPAR research

authors： Müller R,Rieck M,Müller-Brüsselbach S

更新日期：2008-01-01 00:00:00

abstract：:Peroxisome proliferators activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostasis. To the extent that PPAR agonists improve diabetic dyslipidaemia and insulin resistance, these agents have been considered to reduce cardiovascular risk. Ho...

journal_title：PPAR research

authors： Calkin AC,Thomas MC

更新日期：2008-01-01 00:00:00

abstract：:Cells can shift their metabolism between glycolysis and oxidative phosphorylation to enact their cell fate program in response to external signals. Widely distributed α1-adrenergic receptors (ARs) are physiologically stimulated during exercise, were reported to associate with the activating energetic AMPK pathway, and...

journal_title：PPAR research

authors： Lee YJ,Kim HS,Seo HS,Na JO,Jang YN,Han YM,Kim HM

更新日期：2020-02-01 00:00:00

abstract：:Background. This study was performed to investigate the influence of a short-term treatment with pioglitazone versus placebo on inflammatory activation of mononuclear cells (mRNA expression/protein secretion of inflammatory markers). Methods and Results. Sixty-three patients with well-controlled type 2 diabetes (52 ma...

journal_title：PPAR research

authors： Pfützner A,Weise A,Pfützner-Riehn E,Lübben G,Morcos M,Karagiannis E,Weber M,Forst T

更新日期：2011-01-01 00:00:00

abstract：:Pregnancy is a state of immunotolerance, and pregnancy outcome is strongly linked to the correct activation and balancing of the maternal immune system. Besides abortion as possible result of improper early pregnancy development, other pregnancy associated conditions like preeclampsia (PE), intrauterine growth retarda...

journal_title：PPAR research

authors： Hutter S,Knabl J,Andergassen U,Jeschke U

更新日期：2013-01-01 00:00:00

abstract：:While TOFA (acetyl CoA carboxylase inhibitor) and C75 (fatty acid synthase inhibitor) prevent lipid accumulation by inhibiting fatty acid synthesis, the mechanism of action is not simply accounted for by inhibition of the enzymes alone. Liver fatty acid binding protein (L-FABP), a mediator of long chain fatty acid sig...

journal_title：PPAR research

authors： Huang H,McIntosh AL,Martin GG,Petrescu AD,Landrock KK,Landrock D,Kier AB,Schroeder F

更新日期：2013-01-01 00:00:00

abstract：:PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been known as a hallmark o...

journal_title：PPAR research

authors： Du S,Wagner N,Wagner KD

更新日期：2020-08-13 00:00:00

abstract：:Glioblastoma multiforme (GBM) represents one of the most frequent malignant brain tumors. Current therapies do not provide real solutions to this pathology. Their failure can be ascribed to a cell subpopulation with stem-like properties called glioma stem cells (GSCs). Therefore, new therapeutic strategies GSC-targete...

journal_title：PPAR research

authors： Cilibrasi C,Butta V,Riva G,Bentivegna A

更新日期：2016-01-01 00:00:00

abstract：:PPARγ agonists can either enhance or inhibit eosinophil migration, which is a sum of directional migration (chemotaxis) and random cell movement (chemokinesis). To date, the effects of PPAR agonists on chemokinesis have not been examined. This study investigates the effects of PPARα, δ, and γ agonists on eosinophil mi...

journal_title：PPAR research

authors： Smith SG,Imaoka H,Punia N,Irshad A,Janssen LL,Sehmi R,Gauvreau GM

更新日期：2012-01-01 00:00:00

abstract：:Pancreatic cancer is a devastating disease in which current therapies are inadequate. Separate lines of research have identified the 5-lipoxygenase/leukotriene B(4) receptor pathway and the PPARgamma pathway as potential targets for prevention or treatment of this disease. LY293111 was originally designed as a potent ...

journal_title：PPAR research

authors： Adrian TE,Hennig R,Friess H,Ding X

更新日期：2008-01-01 00:00:00