Fenofibrate enhances the in vitro differentiation of foxp3(+) regulatory T cells in mice.

abstract：:Inflammation is a major component in the pathology of chronic lung diseases, including asthma. Anti-inflammatory treatment with corticosteroids is not effective in all patients. Thus, new therapeutic options are required to control diverse cellular functions that are currently not optimally targeted by these drugs in ...

journal_title：PPAR research

authors： Ward JE,Tan X

更新日期：2007-01-01 00:00:00

abstract：:Pregnancy is a state of immunotolerance, and pregnancy outcome is strongly linked to the correct activation and balancing of the maternal immune system. Besides abortion as possible result of improper early pregnancy development, other pregnancy associated conditions like preeclampsia (PE), intrauterine growth retarda...

journal_title：PPAR research

authors： Hutter S,Knabl J,Andergassen U,Jeschke U

更新日期：2013-01-01 00:00:00

abstract：:The peroxisome proliferator-activated receptors (PPARs), which are ligand-inducible transcription factors expressed in a variety of tissues, have been shown to perform key roles in lipid homeostasis. In physiological situations such as fasting and physical exercise, one PPAR subtype, PPARdelta, triggers a transcriptio...

journal_title：PPAR research

authors： de Lange P,Lombardi A,Silvestri E,Goglia F,Lanni A,Moreno M

更新日期：2008-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma), one of three ligand-activated transcription factors named PPAR, has been identified as a molecular target for cancer chemopreventive agents. PPARgamma was initially understood as a regulator of adipocyte differentiation and glucose homeostasis while later o...

journal_title：PPAR research

authors： Sainis I,Vareli K,Karavasilis V,Briasoulis E

更新日期：2008-01-01 00:00:00

abstract：:Hyperhomocysteinemia, a risk factor for vascular disease, is associated with metabolic syndrome. Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling. We also studied oxidative stress and expression of PPARγ in the coronary arteriole as a poss...

journal_title：PPAR research

authors： Huo Y,Wu X,Ding J,Geng Y,Qiao W,Ge A,Guo C,Lv J,Bao H,Fan W

更新日期：2018-01-15 00:00:00

abstract：:Aster glehni is well known for its therapeutic properties. This study was performed to investigate the effects of A. glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue....

journal_title：PPAR research

authors： Lee YJ,Jang YN,Han YM,Kim HM,Jeong JM,Son MJ,Jin CB,Kim HJ,Seo HS

更新日期：2017-01-01 00:00:00

abstract：:Nitrooleic acid (OA-NO2) is endogenous ligands for peroxisome proliferator-activated receptors. The present study was aimed at investigating the beneficial effects of OA-NO2 on the lipid metabolism and liver steatosis in deoxycorticosterone acetate- (DOCA-) salt induced hypertensive mice model. Male C57BL/6 mice were ...

journal_title：PPAR research

authors： Wang H,Sun J,Jia Z,Yang T,Xu L,Zhao B,Yu K,Wang R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism. AIMS:We investigated whether PPARα intron 7 G2468/C and PPARγ2 Pro12Ala and PPARγ exon 6 C161T polymorphisms are associated with serum fetuin-A concentrations. PATIENTS AND METHODS:The PPARα intron 7 G/C po...

journal_title：PPAR research

authors： Márkus B,Vörös K,Supák D,Melczer Z,Cseh K,Kalabay L

更新日期：2017-01-01 00:00:00

abstract：:Stroke (focal cerebral ischemia) is a leading cause of death and disability among adult population. Many pathological events including inflammation and oxidative stress during the acute period contributes to the secondary neuronal death leading the neurological dysfunction after stroke. Transcriptional regulation of g...

journal_title：PPAR research

authors： Vemuganti R

更新日期：2008-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) represents one of the most frequent malignant brain tumors. Current therapies do not provide real solutions to this pathology. Their failure can be ascribed to a cell subpopulation with stem-like properties called glioma stem cells (GSCs). Therefore, new therapeutic strategies GSC-targete...

journal_title：PPAR research

authors： Cilibrasi C,Butta V,Riva G,Bentivegna A

更新日期：2016-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) activation decreased serum testosterone (T) in women with hyperthecosis and/or polycystic ovary syndrome and reduced the conversion of androgens to estradiol (E2) in female rats. This implies modulation of female sex steroid hormones by PPARγ. It is not clear if...

journal_title：PPAR research

authors： Mansour M,Coleman E,Dennis J,Akingbemi B,Schwartz D,Braden T,Judd R,Plaisance E,Stewart LK,Morrison E

更新日期：2009-01-01 00:00:00

abstract：:It has been proposed that PPAR-dependent, accelerated catabolism of proinflammatory mediators may contribute to the fast resolution of inflammation. Because retinoid X receptors are obligate heterodimer partners of PPARs, we investigated the impact of deleting hepatocyte-specific RXRalpha on the antiedema effect of PP...

journal_title：PPAR research

authors： Wan YJ,Badr MZ

更新日期：2006-01-01 00:00:00

abstract：:Cells can shift their metabolism between glycolysis and oxidative phosphorylation to enact their cell fate program in response to external signals. Widely distributed α1-adrenergic receptors (ARs) are physiologically stimulated during exercise, were reported to associate with the activating energetic AMPK pathway, and...

journal_title：PPAR research

authors： Lee YJ,Kim HS,Seo HS,Na JO,Jang YN,Han YM,Kim HM

更新日期：2020-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcriptional factors. Among other functions, PPAR-gamma acts as a key regulator of the adipogenesis. Since several cytokines (IL-1, TNF-alpha, TGF-beta) had been known to inhibit ad...

journal_title：PPAR research

authors： Takada I,Kouzmenko AP,Kato S

更新日期：2010-01-01 00:00:00

abstract：:Pioglitazone (Pio) is a thiazolidinedione (TZD) insulin-sensitizing drug whose effects result predominantly from its modulation of the transcriptional activity of peroxisome proliferator-activated-receptor-gamma (PPARγ). Pio is used to treat human insulin-resistant diabetes and also frequently considered for treatment...

journal_title：PPAR research

authors： Kulkarni S,Huang J,Tycksen E,Cliften PF,Rudnick DA

更新日期：2020-09-10 00:00:00

abstract：:Pancreatic cancer is a devastating disease in which current therapies are inadequate. Separate lines of research have identified the 5-lipoxygenase/leukotriene B(4) receptor pathway and the PPARgamma pathway as potential targets for prevention or treatment of this disease. LY293111 was originally designed as a potent ...

journal_title：PPAR research

authors： Adrian TE,Hennig R,Friess H,Ding X

更新日期：2008-01-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist rosiglitazone inhibits NF-κB expression and endogenous neural stem cell differentiation into neurons and reduces the inflammatory cascade after spinal cord injury (SCI). The aim of this study was to explore the mechanisms underlying rosiglitazone-me...

journal_title：PPAR research

authors： Meng QQ,Lei W,Chen H,Feng ZC,Hu LQ,Zhang XL,Li S

更新日期：2018-06-21 00:00:00

abstract：:Dendritic cells (DCs) can regulate all elements of the immune system, and therefore are an ideal target for vaccination. During the last two decades, as a result of extensive research, DCs became the primary target of antitumor vaccination as well. A critical issue of antitumor vaccination is the phenotype of the dend...

journal_title：PPAR research

authors： Gyöngyösi A,Nagy L

更新日期：2008-01-01 00:00:00

abstract：:Restricted feeding (RF) during daytime is associated with anticipatory activity before feeding, marked hyperphagia after mealtime, adjustments in hepatic metabolism, and the expression of a food-entrained oscillator (FEO). 24 h rhythmicity of liver PPARα, β, and γ, peroxisomal markers (PMP70, AOX, and catalase), and f...

journal_title：PPAR research

authors： Rivera-Zavala JB,Báez-Ruiz A,Díaz-Muñoz M

更新日期：2011-01-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of the women of reproductive age. Familial clustering of PCOS has been consistently reported suggesting that genetic factors play a role in the development of the syndrome although PCOS cases do not exhibit a clear pattern of Mendelian inheritance....

journal_title：PPAR research

authors： Unluturk U,Harmanci A,Kocaefe C,Yildiz BO

更新日期：2007-01-01 00:00:00

abstract：:Irisin is related to insulin resistance and metabolic disorders. The physiologic effects of irisin are partially mediated through peroxisome proliferator-activated receptor-α (PPAR-α). We investigated the effect of fenofibrate, a PPAR-α agonist, on serum irisin in type 2 diabetes patients with hypertriglyceridemia. Th...

journal_title：PPAR research

authors： Feng X,Gao X,Jia Y,Zhang H,Pan Q,Yao Z,Yang N,Liu J,Xu Y,Wang G,Yang X

更新日期：2015-01-01 00:00:00

abstract：:Infection with Mycobacterium tuberculosis (TB) induces pulmonary immunopathology mediated by classical Th1 type of acquired immunity with hepatic involvement in up to 80% of disseminated cases. Since PPAR agonists cause immune responses characterized by a decrease in the secretion of Th1 cytokines, we investigated the...

journal_title：PPAR research

authors： Badr MZ,Shnyra A,Zoubine M,Norkin M,Herndon B,Quinn T,Miranda RN,Cunningham ML,Molteni A

更新日期：2007-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR alpha, beta/delta and gamma) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system. Moreover, PPARs have various extra metabolic roles, in circadian rhythms, inflammation and oxidative st...

journal_title：PPAR research

authors： Lecarpentier Y,Claes V,Hébert JL

更新日期：2010-01-01 00:00:00

abstract：:The cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) is a natural ligand of peroxisome proliferator-activated receptor gamma (PPAR-γ) and a potential mediator of apoptosis in cancer cells. In the present study, we evaluated the effect of 15d-PGJ2 in human thyroid papillary carcinoma cells (TP...

journal_title：PPAR research

authors： Trindade-da-Silva CA,Reis CF,Vecchi L,Napimoga MH,Sperandio M,Matias Colombo BF,Alves PT,Ward LS,Ueira-Vieira C,Goulart LR

更新日期：2016-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Their discovery in the 1990s provided insights into the cellular mechanisms involved in the control of energy homeostasis, the regulation of cell differentiation, prolif...

journal_title：PPAR research

authors： Han SW,Roman J

更新日期：2008-01-01 00:00:00

abstract：:Dysfunction of macro- and microvessels is a major cause of morbidity and mortality in patients with cardio-renovascular diseases such as atherosclerosis, hypertension, and diabetes. Renal failure and impairment of renal function due to vasoconstriction of the glomerular arteriole in diabetic nephropathy leads to renal...

journal_title：PPAR research

authors： Sen U,Tyagi SC

更新日期：2010-01-01 00:00:00

abstract：:While TOFA (acetyl CoA carboxylase inhibitor) and C75 (fatty acid synthase inhibitor) prevent lipid accumulation by inhibiting fatty acid synthesis, the mechanism of action is not simply accounted for by inhibition of the enzymes alone. Liver fatty acid binding protein (L-FABP), a mediator of long chain fatty acid sig...

journal_title：PPAR research

authors： Huang H,McIntosh AL,Martin GG,Petrescu AD,Landrock KK,Landrock D,Kier AB,Schroeder F

更新日期：2013-01-01 00:00:00

abstract：:To investigate the effects of fimasartan on nonalcoholic fatty liver disease in hyperlipidemic and hypertensive conditions, the levels of biomarkers related to fatty acid metabolism were determined in HepG2 and differentiated 3T3-L1 cells treated by high fatty acid and liver and visceral fat tissue samples of spontane...

journal_title：PPAR research

authors： Lee YJ,Jang YN,Han YM,Kim HM,Jeong JM,Seo HS

更新日期：2017-01-01 00:00:00

abstract：:The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Specifically, PPARG has...

journal_title：PPAR research

authors： Bandera Merchan B,Tinahones FJ,Macías-González M

更新日期：2016-01-01 00:00:00

abstract：:Improvements in our understanding of the functions of the nuclear receptor peroxisome proliferator-activated receptor (PPAR) subtypes as pleiotropic regulators of biological responses, including lipid, lipoprotein, glucose homeostasis, inflammation, differentiation and proliferation of various cancer cells, and memory...

journal_title：PPAR research

authors： Miyachi H,Hashimoto Y

更新日期：2008-01-01 00:00:00