Abstract:
:A major endpoint of the canonical Wnt signaling pathway is a change in the transcription of target genes. The transcription factors lymphoid enhancer factor (LEF) and T cell factor (TCF) serve as the main gatekeepers of these changes by selecting genes to be targeted by the transcriptional coregulator beta-catenin and by defining how target gene expression will be altered. Most research has focused on LEF/TCF:beta-catenin-mediated activation of transcription, but there have been some reports that suggest that this complex also directly represses transcription. A recent study uncovered a new mode of repression of Wnt target genes in which recognition of a novel DNA element by TCF specifies that beta-catenin acts as a transcriptional repressor.
journal_name
Sci Signaljournal_title
Science signalingauthors
Hoverter NP,Waterman MLdoi
10.1126/scisignal.139pe43subject
Has Abstractpub_date
2008-09-30 00:00:00pages
pe43issue
39eissn
1945-0877issn
1937-9145pii
scisignal.139pe43journal_volume
1pub_type
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