Remote hemodynamics and renal function in formerly preeclamptic women.

Abstract:

OBJECTIVE:Women with a history of preeclampsia have an increased risk of developing chronic hypertension and cardiovascular disease. However, little is known about the mechanism responsible for vascular disease in formerly preeclamptic women. The aim of our study was to test whether preeclampsia predisposes to central hemodynamic and renal impairments 20 years after pregnancy. METHODS:In this cross-sectional study, 22 formerly preeclamptic women and 29 parous controls participated, matched for body mass index, age, and date of birth. All women delivered in the period of 1979-1987. Measures included automated blood pressure, Doppler echocardiography, microalbuminuria, paraaminohippurate, and creatinine clearances. Hypertension was defined as blood pressure at or above 140/90 mm Hg, using antihypertensive drugs, or both. RESULTS:Hypertension was present in 55% of the formerly preeclamptic women and 7% of the women in the control group (P<.01). Mean arterial pressure was higher in the formerly preeclamptic women compared with those in the control group (100 and 88 mm Hg, respectively, P<.01). Peripheral vascular resistance was about 20% higher, renal vascular resistance about 30% higher, and renal blood flow about 15% lower in the formerly preeclamptic women compared with those in the control group (P<.05). Similar results were observed after stratification for hypertension in both groups. CONCLUSION:Both normotensive and hypertensive middle-aged, formerly preeclamptic women showed impaired central hemodynamic and renal function compared with parous controls. LEVEL OF EVIDENCE:II.

journal_name

Obstet Gynecol

authors

Spaan JJ,Ekhart T,Spaanderman MEA,Peeters LLH

doi

10.1097/AOG.0b013e31819caf0f

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

853-859

issue

4

eissn

0029-7844

issn

1873-233X

pii

00006250-200904000-00015

journal_volume

113

pub_type

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