The effects of mefenamic acid and norethisterone on measured menstrual blood loss.

Abstract:

:Although there are numerous medical treatments for menorrhagia, in many instances neither the precise diagnosis nor the response to therapy have been assessed objectively. Menorrhagia (menstrual blood loss more than 80 mL per cycle) was diagnosed objectively in 32 (44%) of 72 women with a subjective complaint of heavy menses. All of the 32 women had ovulatory cycles. After random allocation to treatment with either mefenamic acid (500 mg three times daily during menses, N = 17) or norethisterone (5 mg twice daily on days 19-26 of the cycle, N = 15) for two additional cycles, the median menstrual blood loss was reduced from 123 mL (range 86-237) to 81 mL (22-193) (P less than .001) and from 109 mL (81-236) to 92 mL (43-189) (P less than .002) with mefenamic acid and norethisterone, respectively. Apart from a decrease in the median number of days of bleeding, from 7 (5-8) to 5 (3-8) in those women treated with mefenamic acid, no other differences were seen between the groups. We conclude that mefenamic acid and norethisterone were similarly effective in reducing the degree of menstrual blood loss in women with proved menorrhagia, but that 52 and 67% of the women, respectively, remained menorrhagic after 2 months of treatment.

journal_name

Obstet Gynecol

authors

Cameron IT,Haining R,Lumsden MA,Thomas VR,Smith SK

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

85-8

issue

1

eissn

0029-7844

issn

1873-233X

journal_volume

76

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章

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    authors: Smith DP,Goldman SM,Beggs DS,Lanigan PJ

    更新日期:1994-05-01 00:00:00

  • Health care provider attitudes and practices related to intrauterine devices for nulliparous women.

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    更新日期:2012-04-01 00:00:00

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    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0029-7844(03)00662-8

    authors: Steiner MJ,Dalebout S,Condon S,Dominik R,Trussell J

    更新日期:2003-10-01 00:00:00

  • Positive rubella titers in pregnancy: a question of validity.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Hall JA,Wills ER,Hall K,Pearson JW

    更新日期:1979-08-01 00:00:00

  • Induction of an LH surge with estradiol benzoate in a patient with incomplete testicular feminization syndrome.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Hochman J,Ganguly M,Weiss G

    更新日期:1977-01-01 00:00:00

  • Patient-prosthesis mismatch in pregnancy.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000000074

    authors: Johnston RC,Swank ML,Shrivastava VK,Hameed AB

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Baumann H,Jaeger P,Huch A

    更新日期:1988-03-01 00:00:00

  • Amyloidosis of the endometrium: an asymptomatic presentation.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

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    authors: Winkler DD,Emery JA,Alan CB

    更新日期:2004-11-01 00:00:00

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

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  • ACOG Committee Opinion No 579: Definition of term pregnancy.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000437385.88715.4a

    authors:

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    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.AOG.0000135274.92416.62

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    更新日期:2004-09-01 00:00:00

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Tulandi T,Bret PM,Atri M,Senterman M

    更新日期:1991-04-01 00:00:00

  • Neonatal outcomes after gestational exposure to nitrofurantoin.

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    pub_type: 杂志文章

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    authors: Nordeng H,Lupattelli A,Romøren M,Koren G

    更新日期:2013-02-01 00:00:00

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Symmonds RE,Pettit PD

    更新日期:1979-08-01 00:00:00

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    abstract::The Eunice Kennedy Shriver National Institute of Child Health and Human Development held a workshop on September 18-19, 2006, to summarize the available evidence on the role and performance of current fetal imaging technology and to establish a research agenda. Ultrasonography is the imaging modality of choice for pre...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000318871.95090.d9

    authors: Reddy UM,Filly RA,Copel JA,Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Department of Health and Human Services, NIH.

    更新日期:2008-07-01 00:00:00

  • The 4-S modification of the Roeder knot: how to tie it.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(97)00492-4

    authors: Sharp HT,Dorsey JH

    更新日期:1997-12-01 00:00:00

  • Surgical management of irradiation-induced small bowel damage.

    abstract::Seventy-seven patients, presenting with radiation small bowel injuries at the University of Texas M. D. Anderson Hospital and Tumor Institute at Houston between 1962 and 1978, were analyzed retrospectively. The patients were divided into two categories: bowel bypass without resection, and resection of irradiated bowel...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Smith ST,Seski JC,Copeland LJ,Gershenson DM,Edwards CL,Herson J

    更新日期:1985-04-01 00:00:00

  • Endocervical strip biopsy instrument: an alternative to endocervical curettage.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Ostergard DR

    更新日期:1980-11-01 00:00:00

  • Cephalothoracopagus (Janiceps) twinning.

    abstract::Conjoined twins occur with a frequency of 1/50,000--1/100,000 deliveries. The cephalothoracopagus variety is particularly rare. This paper presents a case report of cephalothoracopagus (Janiceps) twinning, with a detailed pathologic analysis, as well as an historical review and discussion of diagnostic modalities. ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Wedberg R,Kaplan C,Leopold G,Porreco R,Resnik R,Benirschke K

    更新日期:1979-09-01 00:00:00

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

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    更新日期:2004-03-01 00:00:00

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    更新日期:2000-04-01 00:00:00

  • Thrombocytopenia in term infants: a population-based study.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:

    authors: Wild RA,Hirisave V,Podczaski ES,Coulam C,Shivers CA,Satyaswaroop PG

    更新日期:1991-06-01 00:00:00

  • Antenatal dietary interventions in obese pregnant women to restrict gestational weight gain to Institute of Medicine recommendations: a meta-analysis.

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    pub_type: 杂志文章,meta分析,评审

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    authors: Quinlivan JA,Julania S,Lam L

    更新日期:2011-12-01 00:00:00

  • Using videography to teach retropubic space anatomy and surgical technique.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Shull B

    更新日期:1991-04-01 00:00:00

  • Prenatal prediction of lethal pulmonary hypoplasia using ultrasonic fetal chest circumference.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Songster GS,Gray DL,Crane JP

    更新日期:1989-02-01 00:00:00

  • Weight gain in women with gestational diabetes.

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    doi:

    authors: Catalano PM,Roman NM,Tyzbir ED,Merritt AO,Driscoll P,Amini SB

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  • Hospital variation in postpartum tubal sterilization rates in California and Texas.

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