Abstract:
:We have reviewed the family histories of children with neural tube defects to determine which relatives are at sufficient risk to be offered amniocentesis for prenatal diagnosis. The recurrence risks for sibs was 6%; therefore, women with one affected child should be made aware of the availability of this test for monitoring subsequent pregnancies. The empiric recurrence risks for various groups of second and third degree relative exceeds 1% only for mothers' sisters' children. The lower values for the other groups may reflect either true biologic differences of reporting biases. Unit the matter is clarified, all sibs of affected children and all sibs of the parents of affected children should be informed of the availability of amniocentesis for monitoring their (or their spouse's) pregnancies. :To assess the risk for 2nd- and 3rd-degree relatives of patients with open neural tube defects and thereby identify appropriate candidates for prenatal diagnosis, the histories of 133 families having at least 1 offspring with anencephaly or spina bifida and 13 having disorders unrelated to neural tube defects were reviewed. Mothers of the affected children had a total of 598 pregnancies yielding 364 full and 13 half sibs (12.5% miscarriage rate). 22 of the full sibs were themselves affected with anencephaly or spina bifida, giving a 6% overall recurrence rate among sibs. This statistic is higher than the 4-5% usually cited, due perhaps to the small sample size or the high prevalence of these disorders in the Quebec population. Previous miscarriage does not seem to be a significant factor in determining recurrence risk. The defect rate among 1st cousins (parents' sibs' children) was 0.7% overall, with the rate for maternal cousins (0.9%) higher than that for paternal cousins (0.5%) and the risk for mothers' sisters' children (1.3%) especially high. There were no cases of neural tube defects among mothers' sibs, but a 0.7% rate among fathers' sibs, giving an overall risk of 0.4% for 2nd-degree relatives. This finding is striking since recall biases and a maternal effect should enrich the sample for affected sibs of the mother. It is concluded that although the recurrence risk exceeds 1% (the current criteria for candidates for prenatal testing) only for mothers' sisters' children, all 2nd- and 3rd-degree relatives should be given the option of amniotic AFP testing until it can be determined whether the lower risk values for other groups reflect true biologic differences or reporting biases.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Lippman-Hand A,Fraser FC,Biddle CJsubject
Has Abstractpub_date
1978-01-01 00:00:00pages
72-6issue
1eissn
0029-7844issn
1873-233Xjournal_volume
51pub_type
杂志文章abstract:OBJECTIVE:To estimate the patterns of care and outcome of women with early cervical cancer in the United States based on surgical or radiation intent-to-treat principles. METHODS:The Surveillance, Epidemiology, and End Results 1995 public-use file was the data source. Subjects between the ages of 15 and 80 years at di...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(00)01117-0
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To determine whether women with abnormal Papanicolaou smears who received educational brochures at the initial booking for colposcopy were more likely to complete recommended treatment and follow-up after 18-24 months than were those who did not receive the brochures. METHODS:One hundred eight women particip...
journal_title:Obstetrics and gynecology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006250-199404000-00016
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:To evaluate whether current Joint Commission (JC) exclusion criteria for measure PC-01, "Elective Delivery" before 39 weeks of gestation, accurately identify valid, codeable indications for planned early-term delivery. METHODS:We performed a review and critical analysis of all cases recorded as noncompliant ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000000059
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To examine levels of serum tryptophan and its degradation product kynurenine in uncomplicated pregnancy, according to the week of pregnancy and the concentrations of neopterin. METHODS:Plasma was analyzed from 45 healthy pregnant women (15 in each trimester), 15 healthy puerperas, and 20 nonpregnant controls...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/0029-7844(96)00084-1
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:Epidermal growth factor is a ubiquitous mitogen that also possesses insulin-like properties. Fetal mal-growth is associated with altered epidermal growth factor levels. Maternal diabetes is frequently complicated by macrosomia, but the effect of maternal diabetes on fetal epidermal growth factor levels is not...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/01.AOG.0000110545.64874.49
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:To examine cigarette smoking as a risk factor for different types of epithelial ovarian cancer. METHODS:We used data from the Cancer and Steroid Hormone Study, a multicenter, population-based, case control investigation. Cases were 447 women aged 20-54 years with diagnoses of epithelial ovarian cancer. Contr...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,多中心研究
doi:10.1016/s0029-7844(99)00531-1
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:Maternal anal sphincter tears after vaginal delivery are frequently not diagnosed clinically and are associated with subsequent fecal incontinence. This study examined whether diagnosis of these tears by ultrasonography, followed by immediate surgical repair, reduces the occurrence of incontinence. METHODS:W...
journal_title:Obstetrics and gynecology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.AOG.0000165273.68486.95
更新日期:2005-07-01 00:00:00
abstract::Two hundred seven high-risk patients were studied prospectively by standardized nonstressed fetal heart rate monitoring followed immediately by contraction stress testing (CST). Of the 604 combined procedures examined, 90.2% of nonstress tests (NST) were interpreted as reactive; none was associated with a positive CST...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:To evaluate changes over the past decade in the mode of delivery and second-stage duration in nulliparous women. METHODS:We conducted a retrospective cohort study at a single institution of nulliparous women reaching complete cervical dilation with singleton gestations 36 weeks or greater from January 1, 201...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000000872
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To estimate the efficacy of paracervical block compared with saline for pain relief during office hysteroscopic sterilization. METHODS:This study was a randomized, placebo-controlled study of women desiring hysteroscopic sterilization. A paracervical block of 1% lidocaine or normal saline was administered be...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,随机对照试验
doi:10.1097/AOG.0b013e3181c51ace
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To estimate both human immunodeficiency virus (HIV) testing acceptance rates in pregnancy using an opt-out policy and patient characteristics influencing acceptance. METHODS:At the first prenatal visit, HIV testing was offered using an opt-out approach. Reasons for refusing testing were explored. Demographic...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/01.AOG.0000267497.39041.06
更新日期:2007-07-01 00:00:00
abstract::Parturients with heavy vaginal colonization of group B streptococci were selected randomly to receive either penicillin or no antibiotic. A simple and fast latex agglutination test, applied in 8977 consecutive parturients, detected 412 women with heavy colonization with group B streptococcus, 199 of whom were eligible...
journal_title:Obstetrics and gynecology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-04-01 00:00:00
abstract::Electrical accidents during pregnancy are relatively infrequent, and reports are rare. Six pregnant women who suffered an electrical injury during pregnancy are presented here. For all, the current path through the body was from hand to foot. Changes that occurred in fetal movements and development as well as the outc...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/00006250-198606000-00024
更新日期:1986-06-01 00:00:00
abstract::Marketing of genetic testing, although similar to direct-to-consumer advertising of prescription drugs, raises additional concerns and considerations. These include issues of limited knowledge among patients and health care providers of available genetic tests, difficulty in interpretation of genetic testing results, ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,实务指引
doi:10.1097/AOG.0b013e31817d250e
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Doppler measurement of the fetal middle cerebral artery peak systolic velocity is a valuable tool in detecting the presence of fetal anemia in Rh-sensitized pregnancies. We present a case in which discordant left and right middle cerebral artery Dopplers complicated clinical management. CASE:An RhD-alloimmu...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/01.AOG.0000263463.09931.40
更新日期:2007-08-01 00:00:00
abstract::Human trafficking is a widespread problem with estimates ranging from 14,000 to 50,000 individuals trafficked into the United States annually. This hidden population involves the commercial sex industry, agriculture, factories, hotel and restaurant businesses, domestic workers, marriage brokers, and some adoption firm...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e3182310d06
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To evaluate an office-based test as a screening method for intrinsic sphincter deficiency. METHODS:One hundred seventy-three women with urinary incontinence were evaluated prospectively by complete urodynamic studies. After catheterization, the pediatric Foley catheter test was performed on an empty bladder ...
journal_title:Obstetrics and gynecology
pub_type: 临床试验,杂志文章
doi:10.1016/s0029-7844(01)01344-8
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To analyze the change in serial human chorionic gonadotropin (hCG) levels in women symptomatic with pain or bleeding who presented with nondiagnostic ultrasonography but were ultimately confirmed to have a viable intrauterine pregnancy. METHODS:The rise in serial hCG measures were modeled over time, with the...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/01.AOG.0000128174.48843.12
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of delaying colposcopy in women with negative Papanicolaou smears and positive speculoscopy results. METHODS:This was a prospective study of asymptomatic women ages 13-60 years, regularly scheduled for pelvic examinations. All women had Papanicolaou smears and magnified visual examinat...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(99)00515-3
更新日期:2000-03-01 00:00:00
abstract::It has long been recognized that fatigue can affect human cognitive and physical function. Although there are limited published data on the effects of fatigue on health care providers, including full-time practicing physicians, there is increasing awareness within the patient safety movement that fatigue, even partial...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e3181666025
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To determine whether serum vascular endothelial growth factor is an independent prognostic factor in ovarian cancer patients. METHODS:We measured vascular endothelial growth factor in pretreatment serum samples of 60 women with International Federation of Gynecology and Obstetrics stages I to IV epithelial o...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(98)00190-2
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To prospectively validate the Sepsis in Obstetrics Score, a pregnancy-specific sepsis scoring system, to identify risk for intensive care unit (ICU) admission for sepsis in pregnancy. METHODS:This is a prospective validation study of the Sepsis in Obstetrics Score. The primary outcome was admission to the IC...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000002260
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To assess the rate of wound complications and evaluate the effectiveness of antibiotic prophylaxis in vulvar wide local excision procedures. METHODS:We performed a single-institution, retrospective cohort study of women undergoing vulvar surgery for premalignant lesions between January 2007 and January 2017....
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000003185
更新日期:2019-04-01 00:00:00
abstract::Uterine size was estimated in 66 women before hysterectomy by bimanual examination, uterine sounding, and pelvic ultrasound. The results were compared with weight and dimensions recorded after removal. There was greater error in estimation of uterine size using bimanual examination (standard error of the estimate [SEE...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1986-12-01 00:00:00
abstract::In a cohort analysis of Silastic vacuum extractor deliveries, 65% were completed with the vacuum extractor alone, 24% with outlet forceps, 3% with midforceps, and 7% with cesarean section (vacuum extractor-cesarean). Control groups were formed by using the next sequential forceps delivery, spontaneous vaginal delivery...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
abstract::At puberty, a patient with an imperforate hymen typically presents with a vaginal bulge of thin hymenal tissue with a dark or bluish hue caused by the hematocolpos behind it. Other findings that may be present include an abdominal mass, urinary retention, dysuria, constipation, and dyschezia. On evaluation, the goal i...
journal_title:Obstetrics and gynecology
pub_type: 评论,杂志文章
doi:10.1097/AOG.0000000000003284
更新日期:2019-06-01 00:00:00
abstract::Almost 50% of married female residents become pregnant during their residency. The desire to have a baby and a concern about age influence the decision to become pregnant. Career concerns, financial issues, and child care are less important. In addition, support of the faculty or house staff is not a crucial factor in...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVE:To develop and validate a predictive risk calculator for cesarean delivery among women undergoing induction of labor. METHODS:We performed a population-based cohort study of all women who had singleton live births after undergoing induction of labor from 32 0/7 to 42 6/7 weeks of gestation in the United Stat...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000003696
更新日期:2020-03-01 00:00:00
abstract::Over an 11-year period (1971 to 1981), 212 urinary conduit surgeries were performed by the Department of Gynecology at the University of Texas, M. D. Anderson Hospital and Tumor Institute at Houston. The urinary diversions were performed as part of the pelvic exenteration operation in 154 patients, for radiation injur...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/00006250-198605000-00015
更新日期:1986-05-01 00:00:00
abstract::Obesity is a medical condition that may be associated with bias among health care professionals, and this bias may result in disrespectful or inadequate care of patients with obesity. Obstetrician-gynecologists regularly care for patients with obesity and play an integral role in advocating for best practices in healt...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,实务指引
doi:10.1097/AOG.0000000000003015
更新日期:2019-01-01 00:00:00